Browse > Article
http://dx.doi.org/10.5352/JLS.2010.20.12.1750

Effect of Buan Mulberry on Metabolic Improvement in Streptozotocin-Induced Diabetic Rats  

Lee, Ju-Taek (Department of Biological Science, College of Natural Sciences, Wonkwang University)
Ryu, Jae-Sung (Department of Biological Science, College of Natural Sciences, Wonkwang University)
Kwak, Dong-Hoon (Department of Biological Science, College of Natural Sciences, Wonkwang University)
Park, Yun-Jum (Division of Horticulture and Pet Animal-Plant Science, Wonkwang University)
Kang, Seong-Sun (Buan Agricultural Development & Technology Center)
Kim, Pyoung-Jun (Buan Agricultural Development & Technology Center)
Hwang, Kyung-A (Department of Agrofood Resources, National Academy of Agricultural Science, RDA)
Choo, Young-Kug (Department of Biological Science, College of Natural Sciences, Wonkwang University)
Publication Information
Journal of Life Science / v.20, no.12, 2010 , pp. 1750-1757 More about this Journal
Abstract
This study was designed to evaluate the anti-diabetic effects of Buan mulberries by using an insulin-dependent diabetes mellitus animal model. Several studies have shown that mulberries have metabolism-improving, antioxidant, and lipid-lowering properties in rats with streptozotocin (STZ)-induced diabetes. In this study, Sprague-Dawley male rats were randomly assigned to 1 normal control group and 5 STZ-induced diabetes groups: rats that had STZ-induced diabetes and did not receive any agents (diabetic group; negative control), rats that had STZ-induced diabetes and received insulin (insulin group; positive control), rats that had STZ-induced diabetes and received 0.5% mulberry extract (0.5% mulberry group), rats that had STZ-induced diabetes and received 1.0% mulberry extract (1.0% mulberry group), and rats that had STZ-induced diabetes and received 2.0% mulberry extract (2.0% mulberry group). Mulberry extracts were administered to the diabetic animals for 4 weeks. The rats that received mulberry extracts showed lower body weights and insulin levels, as well as higher kidney weights, blood glucose levels, urine quantities, and water intake in comparison with the normal controls. Further, the insulin concentrations in the mulberry-fed animals were higher than those in the diabetic group, and the kidney weights, blood glucose levels, urine quantities, and water intake in the mulberry-fed animals were lower than the corresponding values in the diabetic controls. These results suggest that mulberry may be an effective functional food to prevent diabetes-related complications.
Keywords
Buan mulberry; diabetes mellitus; streptozotocin (STZ); oral administration; insulin;
Citations & Related Records
Times Cited By KSCI : 9  (Citation Analysis)
연도 인용수 순위
1 Shin, D. H. 1998. Antioxidative substance in mulberry leaves. J. Korean Oil Chemists Soc. 16, 27-31.
2 Kwon, E. H., H. S. Jang, S. W. Kim, S, W. Choi, S. J. Rhee, and S. H. Cho. 2007. Effects of mulberry juice and cake powders on blood glucose and lipid lowering and erythrocytic antioxidative enzye activities in streptozotocin-induced diabetic rats. Korean J. Nutr. 40, 199-210.   과학기술학회마을
3 Lau, A. L., and M. L. Failla. 1984. Urinary excretion of zinc, copper and iron in the streptozoticin-diabetic rat. J. Nutr. 114, 223-224.
4 Lee, J. S., H. S. Son, Y. S. Maeng, Y. K. Chang, and J. S. Ju. 1994. Effect of buck wheat on organ weight. Glucose and lipid metabolism in stereptozotocin induced diabetic rats. J. Korean Nutr. 27, 819-827.   과학기술학회마을
5 Mohos, S. C. and L. Skoza. 1969. Glomerular sialoprotein. Science 164, 1519-1521.   DOI
6 Mogensen, C. E., W. F. Keane, P. H. Bennett, G. Jerums, H. H. Parving, P. Passa, M. W. Steffes, G. E. Striker, and G. C. Viberti. 1995. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet 346, 1080-1084.   DOI
7 Narayan, E. S., K. Kasiviswanathan, and I. M. N. Sitaram. 1967. Effect of varietal feeding, irrigation levels and nitrogen fertillization on larvae of Bombyx mori L. Indian J. Seric. 1, 109-117.
8 Park, M. J., S. J. Kang, and A. J. Kim. 2009. Hypoglycemic effect of angelica gigas naki extract in streptozotocin-induced diabetic rats. Korean J. Food Nutr. 22, 246-251.   과학기술학회마을
9 Qiu, L., C. Zhang, J. Zhang, J. Liang, J. Liu, C. Ji, and J. Y. Yang. 2009. Intraperitoneal co-administration of thymosin $\alpha$-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 mice. Int. J. Mol. Med. 23, 597-602.
10 Ritz, E. and S. R. Orth. 1999. Nephropathy in patients with type 2 diabetes mellitus. N. Engl. J. Med. 341, 1127-1133.   DOI
11 Kim, M. W. 2000. The antidiabetic properties of fractions of Lycopus Lucidic Turcz in streptozotocin diabetic rats. Korean J. Soc. Food Sci. 16, 644-651.   과학기술학회마을
12 Kim, O. K. 2009. Antidiabetic and antioxidative effect of Lycii fructus in streptozotocin-induced diabetic rats. Korean J. Pharmacogn. 40, 128-136.   과학기술학회마을
13 Kim, O. K. 2009. Antioxidative effect of polygoni radix in streptozotocin-induced diabetic rats. Korean J. Pharmacogn. 40, 213-217   과학기술학회마을
14 Kim, S. Y., K. J. Park, and W. C. Lee. 1998. Antiinflamatory and antioxidative effect of Morus spp. Fruit extract. Korean J. Medical Crop. Sci. 6, 204-209.
15 Kwon, E. H., M. A. Jung, S. J. Rhee, S. W. Choi, and S. H. Cho. 2006. Antioxidant effects and improvement of lipid metabolism of mulberry fruit, mulberry leaves and silkworm powder with different mixing ratios in streptozotocin-induced diabetic rats. Korean J. Nutr. 39, 91-99.   과학기술학회마을
16 Kim, T. W., Y. B. Kwon, J. H. Lee, I. S. Yang, J. K. Youm, H. S. Lee, and J. Y. Moon. 1996. A study on the antidiabetic effect of mulberry fruit. Korean J. Seric. Sci. 38, 100-107.   과학기술학회마을
17 Kimura, T., K. Nakagawa, Y. Saito, K. Yamagishi, M. Suzuki, K. Yamaki, H. Shinmoto, and T. Miyazawa. 2004. Determination of 1-deox-ynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. J. Agric. Food Chem. 52, 1415-1418   DOI
18 Krishnaswami, S., M. K. R. Naomani, and M. M. Ahsan. 1970. Studies on the quality of mulberry leaves and silkworm cocoon crop production. Part1: Quality differences due to varieties. Indian J. Seric. 9, 1-10.
19 Gavin, J. R., K. G. M. M. Alberti, M. B. Davidson, R. A. Defronzo, A. Drash, S. G. Gabbe, S. Genuth, M. I. Harris, R. Kahn, H. Keen, W. C. Knowler, H. Lebovitz, N. K. Maclaren, J. P. Palmer, P. Raskin, R. Rizza, and M. P. Stern. 2002. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 25, S5-S20.   DOI
20 Ghosh, S. and S. A. Suryawanshi. 2001. Effect of vinca rosea extracts in treatment of alloxan diabetes in male albino rats. J. Exp. Biol. 39, 748-759.
21 Holthofer, H., J. Reivinen, M. L. Solin, A. Haltia, and A. Miettinen. 1996. Decrease of glomerular disialogangliosides in puromycin nephrosis of the rat. American J. Pathol. 149, 1009-1015.
22 Kim, C. S., Y. S. Lee, J. S. Kim, and Y. H. Hahn. 2000. High performance liquid chromatographic analysis of isoflavones in soybean food. J. Korean Food Sci. Technol. 32, 23-30.   과학기술학회마을
23 Kim, M. W. 2000. Effects of $H_2O$ fraction of dioscorea japonica thumb with vitamin E on glucose and lipid metabolism in streptozotocin indued diabetic rats. Korean J. Soc. Food Sci. 13, 500-506.   과학기술학회마을
24 Kim, H. B., S. Y. Kim, K. S. Ryu, W. C. Lee, and J. Y. Moon. 2001. Effect of methanol extract from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemia rats. Korean J. Seric. Sci. 43, 104-108.   과학기술학회마을
25 Kim, H. B., K. J. Park, Y. S. Seuk, S. L. Kim, G. B. Sung, H. W. Nam, and J. Y. Moon. 2002. Mophological characteristics and physiological effects of mulberry leaves and fruits with wild varieties. Korean J. Seric. Sci. 44, 4-8.   과학기술학회마을
26 Kim, H. B., A. J. Kim, and S. Y. Kim. 2003. The analysis of functional materials in mulberry fruit and food product development trends. Food Science and Industry 36, 49-60.
27 Chandler, E. A., J. M. Evans, W. B. Singleton, F. G. Startup, J. B. Sutton, and W. D. Tavernor. 1979. Diabetes mellitus (hypoinsulinism). Canine medicine and therapeutics. pp. 182-186, Oxford: Blackwell Scientific Publications. Oxford.
28 Asano, N., T. Yamashita, K. Yasuda, K. Ikeda, Y. Kameda, A. Kato, R. J. Nash, H. S. Lee, and K. S. Ryu. 2001. Polyhydroxy alkaloids islated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric. Food Chem. 49, 4208-4213.   DOI
29 Atkinson, M. A. and N. K. Maclaren. 1994. The pathogenesis of insulin dependent diabetes. N. Engl. J. Med. 331, 1428-1436.   DOI
30 Birchard, S. J. and R. G. Sherding. 2000. Diabetes mellitus. Saunders manual of small animal practice. pp. 274-287, 2nd eds., WB Saunders Company. Philadelphia.
31 Ettinger, S. J. 1983. Hypoinsulinism (Diabetes mellitus). Textbook of veterinary internal medicine, Diseases of the dog and cat. pp. 1619-1633, 2nd eds., WB Saunders Company. Philadelphia.