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http://dx.doi.org/10.5352/JLS.2010.20.11.1725

Normal Lung Ventilation/Perfusion Scintigraphy in Miniature Pigs  

Kim, Se-Eun (College of Veterinary Medicine, Chonnam National University)
Han, Ho-Jae (College of Veterinary Medicine, Chonnam National University)
Shim, Kyung-Mi (Department of Radiology, Nambu University)
Publication Information
Journal of Life Science / v.20, no.11, 2010 , pp. 1725-1728 More about this Journal
Abstract
Miniature pigs are widely used in experiments related to pulmonary disease because of their similarities with humans. However, there are not enough data about normal lung function in miniature pigs. Thus, in this study, we investigated normal lung function in miniature pigs with lung ventilation/perfusion scintigraphy and evaluated the availability of this method. Three male miniature pigs weighing 30-35 kg were used. After general anesthesia, ventilation scintigraphy was performed with 100 MBq of $^{99m}Tc$-pertechnetate (${O_4}^-$), after which perfusion scintigraphy was performed with intravenous injection of $^{99m}Tc$-macro aggregated albumin (MAA). The functional contribution of the right lung was about 55%, and left lung was about 45%, similar to humans. Lung ventilation/perfusion scintigraphy was very useful in evaluating the normal lung function of miniature pigs because it was a non-invasive procedure (no tissue damage was involved), took a short time and was easy to perform. In conclusion, miniature pigs are similar to humans in functional contributions of the lung, and this method will be helpful in future pulmonary disease studies involving miniature pigs.
Keywords
$^{99m}Tc$-pertechnetate; $^{99m}Tc$-macro aggregated albumin; lung ventilation-perfusion scintigraphy; miniature pig;
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1 Sullivan, P. J., W. M. Burke, W. M. Burch, and F. E. Lomas. 1988. A clinical comparison of Technegas and xenon-133 in 50 patients with suspected pulmonary embolus. Chest 94, 300-304.   DOI
2 Tiel-van Buul, M. M. C. and J. F. Verzijlbergen. 2004. Ventilation-perfusion lung scintigraphy. Imaging Decisions 4, 3-14.
3 Kasper, W., T. Meinertz, B. Henkel, D. Eissner, K. Hahn, T. Hofmann, A. Zeiher, and H. Just. 1986. Echocardiographic findings in patients with proved pulmonary embolism. Am. Heart J. 112, 1284-1290.   DOI
4 Kirschvink, N. and P. Reinhold. 2008. Use of alternative animals as asthma models. Curr. Drug Targets 9, 470-484.   DOI
5 Koh, C. S. 1997. Nuclear medicine, pp. 421-438, 2nd eds., Korea Medical Book Publisher, Seoul.
6 Luna, C. M., O. Sibila, C. Agusti, and A. Torres. 2009. Animal models of ventilator-associated pneumonia. Eur. Respir. J. 33, 182-188.   DOI
7 Maki, D. D., W. B. Gefter, and A. Alavi. 1999. Recent advances in pulmonary imaging. Chest 116, 1388-1402.   DOI
8 Kwak, M. H., J. O. Oh, J. O. Jeong, K. C. Kim, H. S. Kim, H. C. Lee, S. C. Lee, H. C. Gwon, H. J. Kim, K. P. Hong, J. E. Park, J. D. Seo, W. R. Lee, and S. W. Park. Role of echocardiography as a screening test in patients with suspected pulmonary embolism. Korean Circulation J. 31, 500-506.
9 Palmer, J. U. Bitzen, B. Jonson and M. J. Bajc. 2001. Comprehensive ventilation/perfusion SPECT. Nucl. Med. 42, 1288-1294.
10 Smith, A. C. and M. M. Swindle. 2006. Preparation of swine for the laboratory. ILAR J. 47, 358-363.   DOI   ScienceOn
11 Park, B. J., P. W. Park, Y. M. Shim, Y. T. Lee, K. H. Park, J. G. Kim, W. S. Kim, and K. I. Sung. 2009. Pulmonary embolectomy for treatment of pulmonary embolism. Korean J. Thorac. Cardiovasc. Surg. 42, 492-496.   과학기술학회마을
12 Pavan, D., G. L. Nicolosi, F. Antonini-Canterin, and D. Zanuttini. 1998. Echocardiography in pulmonary embolism disease. Int. J. Cardiol. 65, S87-S90.   DOI
13 Rimkus, D. S. and W. L. Ashburn. 1990. Lung ventilation scanning with a new carbon particle radioaerosol (Technegas). Preliminary patient studies. Clin. Nucl. Med. 15, 222-226.   DOI
14 Choi, Y. H., S. E. Kim, D. S. Lee, J. K. Chung, M. C. Lee, K. Y. Kim, C. S. Koh, and S. S. Koong. 1990. Comparison of lung ventilation scan using technegas and $^{99m}Tc$-DTPA aerosol. Korean J. Nucl. Med. 24, 237-243.   과학기술학회마을
15 Baile, E. M., G. G. King, N. L. Muller, Y. D'Yachkova, E. E. Coche, P. D. Pare, and J. R. Mayo. 2000. Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism. Am. J. Respir. Crit. Care Med. 161, 1010-1015.   DOI   ScienceOn
16 Bajc, M., U. Bitzen, B. Olsson, V. Perez de Sa, J. Palmer, and B. J. Jonson. 2002. Lung ventilation/perfusion SPECT in the artificially embolized pig. Nucl. Med. 43, 640-647.
17 Burkill, G. J., J. R. Bell, and S. P. Padley. 1999. Survey on the use of pulmonary scintigraphy, spiral CT and conventional pulmonary angiography for suspected pulmonary embolism in the British Isles. Clin. Radiol. 54, 807-810.   DOI