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http://dx.doi.org/10.5352/JLS.2009.19.7.976

Effect of Alliin on Vascular Functions  

Seo, Jeong-Hwa (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Kim, Jeong-Min (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Ahn, Sun-Young (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Cho, Jin-Gu (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Kim, Jong-Min (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Park, Heon-Yong (Department of Molecular Biology & Institute of Nanosensor and Biotechnology, BK21 Graduate Program for RNA Biology, Dankook University)
Publication Information
Journal of Life Science / v.19, no.7, 2009 , pp. 976-982 More about this Journal
Abstract
Little is known about the cardiovascular roles of alliin, a functional component in garlic that has been used as food material. Thus, we examined a broad range of cardiovascular activities of alliin in this study. From our in vitro experiments, alliin was determined to act as a stimulant to induce endothelial cell proliferation and endothelial cell migration. Since endothelial cell proliferation and migration are highly associated with angiogenesis and wound healing, alliin is suggested as a regulator to control angiogenesis and wound healing. In addition, alliin was elucidated to prevent lipopolysaccharide (LPS)-induced adhesion of THP-1 leukocytes to endothelial cells and LPS-induced homotypic THP-1 cell aggregation. These inhibitory effects indicate that alliin is likely to act as an anti-atherosclerotic and anti-thrombotic factor, because leukocytic adhesion to endothelial cells and homotypic leukocyte aggregation are highly associated with atherosclerosis and thrombosis, respectively. Our additional findings show that alliin has no effect on the production of nitric oxide (NO), an important vasoregulator. In conclusion, alliin is suggested as a regulator for controlling various cardiovascular functions.
Keywords
Alliin; endothelial cells; adhesion; migration; proliferation;
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1 Saluki-Juszczak, J. and B. Wachowicz. 2005. The proinflammatory activity of lipopolysaccharide. Postepy Biochem. 51, 280-287
2 Sangeetha, T. and S. D. Quine. 2006. Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury. J. Pharm. Pharmacol. 58, 617-623   DOI   ScienceOn
3 Sangeetha, T. and S. D. Quine. 2007. Preventive effect of S-allyl cysteine sulfoxide (alliin) on lysosomal hydrolases and membrane-bound ATPases in isoproterenol-induced myocardial infarction in Wistar rats. J. Biochem. Mol. Toxicol. 21, 118-124   DOI   ScienceOn
4 Sheela, C. G. and K. T. Agusti. 1995. Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol fed rats. Indian J. Exp. Biol. 33, 337-341
5 Warshafsky, S., R. S. Kamer, and S. L. Sivak. 1993. Effect of garlic on total serum cholesterol. A meta-analysis. Ann. Intern. Med. 119, 599-605   DOI   ScienceOn
6 Nakamura, H. and M. Ishikawa. 1971. Effect of S-allyl cysteine sulphoxide on cholesterol metabolism. Kanzo. 12, 673-675   DOI
7 Rabinkov, A., T. Miron, L. Konstantinovski, M. Wilchek, D. Mirelman, and L. Weiner. 1998. The mode of action of allicin : trapping of radicals and interaction with thiol containing proteins. Biochim. Biohys. Acta. 1379, 233-244   DOI   ScienceOn
8 El-Sabban, F. and H. Abouazra. 2008. Effect of garlic on atherosclerosis and its factors. East Mediterr. Health J. 14, 195-205
9 Galkina, E. and K. Ley. 2009. Immune and inflammatory mechanisms of atherosclerosis. Annu. Rev. Immunol. Rev. 27, 165-197   DOI   ScienceOn
10 Gebhardt, R. 1993. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids 28, 613-619   DOI   ScienceOn
11 Iberl, B., G. Winkler, B. Muller, and K. Knobloch. 1990. Quantitative determination of allicin and alliin from garlic by HPLC. Planta Med. 56, 320-326   DOI   ScienceOn
12 Iciek, M., I. Kwiecien, and L. Wlodek. 2009. Biological properties of garlic and garlic-derived organosulfur compounds. Environ. Mol. Mutagen. Rev. 50, 247-265   DOI   ScienceOn
13 Libby, P., P. M. Ridker, and A. Maseri. 2002. Inflammation and Atherosclerosis. Circulation 105, 1135-1143   DOI   ScienceOn
14 Kaperonis, E. A., C. D. Liapis, J. D. Kakisis, D. Dimitroulis, and V. G. Papavassiliou. 2006. Inflammation and atherosclerosis. Eur. J. Vasc. Endovasc. Surg. 31, 386-393   DOI   ScienceOn
15 Kourounakis, P. N. and E. A. Rekka. 1991. Effect on active oxygen species of alliin and Allium sativum (garlic) powder. Res. Commun. Chem. Pathol. Pharmacol. 74, 249-252
16 Lebon, A. M., M. F. Vernevaut, L. Guneno, R. Kahane, J. Auger, I. Arnault, T. Haffner, and M. H. Siess. 2002. Effects of garlic powder with varying alliin contents on hepatic drug metabolizing enzymes in rats. Asian Pac. J. Cancer Prev. 3, 339-344
17 Moncada, S. and A. Higgs. 1993. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329, 2002-2012   DOI   ScienceOn
18 Banerjee, S. K. and S. K. Maulik. 2002. Effect of garlic on cardiovascular disorders. Nut. J. Rev. 19, 1-4
19 Ariga, T. and T. Seki. 2006. Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review. Biofactors 26, 93-103   DOI
20 Balsara, R. D. and V. A. Ploplis. 2008. Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thromb. Haemost. 100, 1029-1036
21 Brune, B. 2003. Nitric oxid : NO apoptosis or turning it ON? Cell Death Differ. 10, 864-869   DOI   ScienceOn
22 Choi, S., J. Park, J. Kim, K. In, and H. Park. 2008. Acanthopanax senticosus extract acts as an important regulator for vascular functions. J. Life Science 18, 701-707   DOI   ScienceOn