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http://dx.doi.org/10.5352/JLS.2009.19.7.886

A comprehensive Analysis of a Large Panel of Cancer/Testis (CT) Antigens in Korea Breast Cancer  

Bae, Jae-Ho (Departments of Biochemistry School of Medicine, Pusan National University)
Kim, Min-Ju (Departments of Biochemistry School of Medicine, Pusan National University)
Park, Hae-Rim (Departments of Biochemistry School of Medicine, Pusan National University)
Song, Myung-Ha (Departments of Biochemistry School of Medicine, Pusan National University)
Kim, Jee-Yeon (pathology)
Lee, Chang-Hun (pathology)
Kwak, Hi-Suk (Surgery)
Lee, Sang-Yull (Departments of Biochemistry School of Medicine, Pusan National University)
Publication Information
Journal of Life Science / v.19, no.7, 2009 , pp. 886-891 More about this Journal
Abstract
Cancer/testis (CT) antigens are immunogenic in cancer patients, exhibit highly tissue-restricted expression, and are considered promising target molecules for cancer vaccines. We investigated the expression of 13 CT genes in 29 Korean patients with primary breast carcinoma. The most frequently expressed CT genes were MAGE-3 (66%) and MAGE-1 (57%), followed by LAGE-1 (55%), NY-SAR-35 (49%), MAGE-4 (41%), NY-ESO-1 (38%), CT-7 (24%) and SSX-4 (24%), whereas SSX-1, SSX-2, MAGE-10 and NY-TLU-57 were found to be expressed significantly less often (3-7%) and SCP-l not all. Expression of at least one antigen was observed in 28 breast cancer samples. Immunohistochemistry was performed for NY-ESO-l and MAGE-3 protein expression in breast tumor samples. NY-ESO-l and MAGE-3 proteins were expressed in 11 of 29 (38%) and 12 of 29 (41 %) breast tumors. Our results suggest that CT antigens may be potential candidates for polyvalent immunotherapy in Korean breast cancer patients.
Keywords
Breast cancer; cancer/testis (CT) antigen; cancer immunotherapy; NY-ESO-1; MAGE-3;
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1 Russo, V., C. Traversari, A. Verrecchia, M. Mottolese, P. G. Natali, and C. Bordignon. 1995. Expression of the MAGE gene family in primary and metastatic human breast cancer: implications for tumor antigen-specific immunotherapy. Int. J. Cancer 64, 216-221   DOI   ScienceOn
2 Scanlan, M. J., A. J. Simpson, and L. J. Old. 2004. The cancer/ testis genes: review, standardization, and commentary. Cancer Immun. 4, 1
3 Seregni, E., A. Coli, and N. Mazzucca. 2004. Circulating tumour markers in breast cancer. Eur. J. Nucl. Med. Mol. Imaging 31 (Suppl 1), 15-22   DOI
4 Simpson, A. J., O. L. Caballero, A. Jungbluth, Y. T. Chen, and L. J. Old. 2005. Cancer/testis antigens, gametogenesis and cancer. Nat. Rev. Cancer 5, 615-625   DOI   ScienceOn
5 Slamon, D. J., B. Leyland-Jones, S. Shak, H. Fuchs, V. Paton, A. Bajamonde, T. Fleming, W. Eiermann, J. Wolte , M., Pegram, J. Baselga, and L. Norton. 2001. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792   DOI   ScienceOn
6 Van den Eynde, B., O. Peeters, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. Exp. Med. 182, 689-698   DOI   ScienceOn
7 van der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, E. B. Van den, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254, 1643-1647   DOI
8 Vaughan, H. A., S. Svobodova, D. SMacgregor D, S. Sturrock , A. A. Jungbluth, J. Browning, I. D. Davis, P. Parente, Y. T. Chen, E. Stockert, F. St Clair, L. J. Old, and J. Cebon. 2004. Immunohistochemical and molecular analysis of human melanomas for expression of the human cancer- testis antigens NY-ESO-1 and LAGE-1. Clin. Cancer Res. 10, 8396-8404   DOI   ScienceOn
9 Lee, S. Y., Y. Obata, M. Yoshida, E. Stockert, B. Williamson, A. Jungbluth, Y. T. Chen, L. J. Old, and M. J. Scanlan. 2003. Immunomic analysis of human sarcoma. Proc. Natl. Acad. Sci. USA 100, 2651-2656   DOI   ScienceOn
10 Marchandab, M., C.J.A. Puntc, S. Aamdald, B. Escudiere, W.H.J. Kruitf, U. Keilholzg, L. Håkanssonh, N. van Barenab, Y. Humbletb, P. Muldersc, M.-F. Avrile, A. M. M. Eggermontf, C. Scheibenbogeng, J. Uitersi, J. Wandersi, M. Delirej, T. Boona, and G. Stoterf. 2003. Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report. Eur. J. Cancer 39, 70-77   DOI   ScienceOn
11 Mashino, K. N., F. Sadanaga, H. Tanaka, H. Yamaguchi, H. Nagashima, I. K. Sugimachi, and M. Mori. 2001. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br. J. Cancer 85, 713-720   DOI   ScienceOn
12 Mischo, A., B. Kubuschok, K. Ertan, K. D. Preuss, B. Romeike, E. Regitz, C. Schormann,D. Bruijn, A. Wadle, F. Neumann, W. Schmidt, C. Renner, and M. Pfreundschuh. 2006. Prospective study on the expression of cancer testis genes and antibody responses in 100 consecutive patients with primary breast cancer. Intl. J. Cancer 118, 696-703   DOI   ScienceOn
13 Rentzsch, C., S. Kayser, S. Stumm, I. Watermann, S. Walter, S. Stevanovic, D. Wallwiener, and B. Guckel. 2003. Evaluation of pre-existent immunity in patients with primary breast cancer: molecular and cellular assays to quantify antigen-specific T lymphocytes in peripheral blood mononuclear cells. Clin. Cancer Res. 9, 4376-4386
14 Greenlee, R. T., T. Murray, S. Bolden, and P. A. Wingo. 2000. Cancer statistics. CA Cancer J. Clin. 50, 7-33   DOI   ScienceOn
15 Rimoldi, D., V. Rubio-Godoy, V. Dutoit, D. Lienard, S. Salvi, P. Guillaume, D. Speiser, E. Stockert, G. Spagnoli, C. Servis, J. C. Cerottini, F. Lejeune, P. Romero, and D. Valmori. 2000. Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma. J. Immunol. 165, 7253-7261   DOI
16 Boel, P. C., M. L. Wildmann, R. Sensi, J. C. Brasseur, P. Renauld, T. Boon, and B. P. van der. 1995. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity 2, 167-175   DOI   ScienceOn
17 Chen, Q., H. Jackson, P. Parente, T. Luke, M. Rizkalla, T. Y. Tai, H. C. Zhu, N. A. Mifsud, N. Dimopoulos, K. A. Masterman, W. Hopkins, H. Goldie, E. Maraskovsky, S. Green, L. Miloradovic, J. McCluskey, L. J. Old, I. D. Davis, J. Cebon, and W. Chen. 2004. Immunodominant $CD4^{+}$ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant. Proc. Natl Acad. Sci. USA 101, 9363-9368   DOI   ScienceOn
18 Lee, S. Y. , B. Williamson, O. L. Caballero, Y. T. Chen, M. J. Scanlan, G. Ritter, C. V. Jongeneel, A. J. Simpson, and L. J. Old. 2004. Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer Immun. 17, 4-13
19 Lee, S. Y. 2007. SEREX; discovery of tumor antigens. J. Life Science 17, 841-846   DOI   ScienceOn