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http://dx.doi.org/10.5352/JLS.2009.19.3.299

Human IL-27p28 Gene Polymorphisms are Associated with the Serum Total IgE Levels of Allergic Rhinitis Patients  

Yu, Ji-In (Department of Pathology, Wonkwang University School of Medicine)
Han, Weon-Cheol (Department of Pathology, Wonkwang University School of Medicine)
Lee, Jae-Hoon (Department of Otolaryngology, Wonkwang University School of Medicine)
Kim, Hun-Soo (Department of Pathology, Wonkwang University School of Medicine)
Yun, Ki-Jung (Digestive Disease Research Institute, Wonkwang University School of Medicine)
Lee, Jae-Hoon (Department of Internal Medicine, Wonkwang University School of Medicine)
Moon, Hyung-Bae (Department of Pathology, Wonkwang University School of Medicine)
Chae, Soo-Cheon (Department of Pathology, Wonkwang University School of Medicine)
Publication Information
Journal of Life Science / v.19, no.3, 2009 , pp. 299-304 More about this Journal
Abstract
Interleukin 27 (IL-27) was discovered as a heterodimeric cytokine of the IL-12 family, and is composed of two subunits - Epstein-Barr virus induced gene 3 (EBI3) and p28. It acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA binding protein 3 (GATA-3). This cytokine is mediated by the IL-27 receptor (WSX-1), which is highly expressed on $CD4^+$ T lymphocytes and NK cells. We previously identified four polymorphisms in the human IL-27p28 gene and suggested that the polymorphism of IL-27p28 is associated with susceptibility to asthma. To determine whether these IL-27p28 SNPs are associated with susceptibility to allergic rhinitis, the genotype and allele frequencies of IL-27p28 SNPs were analyzed between allergic rhinitis patients and healthy controls. Although the genotype and allele frequencies of IL-27p28 SNPs in allergic rhinitis patients were not significantly different from those of the control group, there was a suggestive difference (P=0.037) between these groups in total serum IgE levels in the g.2905T>G SNP of the IL-27p28 gene. Our result implies that the g.2905T>G SNP of the IL-27p28 gene might have an affect on IgE production in allergic rhinitis patients.
Keywords
Interleukin 27 (IL-27); polymorphism; haplotype; allergic rhinitis; IgE;
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