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http://dx.doi.org/10.5352/JLS.2009.19.12.1808

Inhibitory Effects of a Herbal Composition (HemoHIM) on the Activation of Human Mast Cell Line (HMC-1)  

Kim, Jong-Jin (Dept. of Biology, College of Life Science and natural Resources, Sunchon National University)
Jo, Sung-Kee (Radiation Research Division for Bio-Technology, Advanced Radiation Technology Institute, Jeongeup campus of Korea Atomic Energy Research Institute)
Jung, U-Hee (Radiation Research Division for Bio-Technology, Advanced Radiation Technology Institute, Jeongeup campus of Korea Atomic Energy Research Institute)
Park, Hae-Ran (Radiation Research Division for Bio-Technology, Advanced Radiation Technology Institute, Jeongeup campus of Korea Atomic Energy Research Institute)
Yee, Sung-Tae (Dept. of Biology, College of Life Science and natural Resources, Sunchon National University)
Publication Information
Journal of Life Science / v.19, no.12, 2009 , pp. 1808-1814 More about this Journal
Abstract
In our previous study, a new herbal preparation (HemoHIM) was developed as a functional food for the radioprotection and immunomodulatory agents. In order elucidate the mechanism involved, we examined the effect of HemoHIM on the compound 48/80-induced histamine release, and on the phorbol 12-myristate 13-acetate (PMA)/calcium ionophore (A23187)-induced inflammatory cytokine secretion in HMC-1. The cell culture supernatants were harvested, and the cytokines (IL-4, IL-6, IL-8, TNF-$\alpha$, GM-CSF) in the supernatants were measured by enzyme-linked immunosorbent assay. The total RNA of the cells was extracted, and the cytokines or c-kit/tryptase/Fc$\varepsilon$RI's messenger RNA expressions were examined using reverse transcriptase polymerase chain reaction. Under low concentrations, HemoHIM inhibited histamine release in HMC-1 stimulated compound 48/80. Furthermore HemoHIM inhibited PMA/A23187-induced inflammatory cytokines' secreation or mRNA expression in a dose-dependent manner. But IL-8 secretion was not inhibited by low concentrayion of HemoHIM, respectively. The mRNA expression of c-kit and Fc$\varepsilon$RI were also inhibited in a dose-dependent manner. Tryptase mRNA expression was only inhibited by low concentration of HemoHIM. These results indicated that HemoHIM might be an useful agent for protection against allergy as well as immune modulation, especially since it is a relatively nontoxic natural product.
Keywords
HMC-1; HemoHIM; histamine; inflammatory cytokine; allergy;
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1 Payne, V. and P. C. Kam. 2004. Mast cell tryptase. a review of its physiology and clinical significance. Anaesthesia 59, 695-703   DOI   ScienceOn
2 Platts-Mills, T. 2001. Hypersensitivity-Type I, pp. 323-343, In Roitt, I., J. Brostoff, and D. Male (6th eds.), Immunology, Gower medical publishing
3 Scheller, S., S. Dworniczak, T. Pogorzelska, M. Rajca, and J. Shani. 2000. Effect of quercetin, caffeic acid and caffeic acid phenylethyl ester, solubilized in non-ionic surfactants, on histamine release in vivo and in vitro. Arzneimittelforschung. 50, 72-76
4 Seo, U. K., J. I. Lee, J. H. Park, and Y. K. Park. 2008. The ethylacetate extract of north kangwhal (Ostericum koreanum) attenuates the inflammatory responses in PM A/ A23187-stimulated mast cells. Kor. J. Herbology 23, 81-89
5 Shin, T. Y. and D. K. Kim. 2000. Inhibitory effect of mast cell-dependent anaphylaxis by Gleditsia sinesis. Arch. Pharm. Res. 23, 401-406   DOI   ScienceOn
6 Tasaka, K., M. Mio, K. Izushi, and I. Aoki. 1991. Role of the cytoskeletons on $Ca^{2+}$ release from the intracellular $Ca^{2+}$ store of rat peritoneal mast cell Skin. Pharmacol. 4, 43-52
7 Yoshii, N., M. Mio, M. Akagi, and K Tassaka. 1991. Role of endoplasmic reticulum, an intracellular $Ca^{2+}$ store in histamine release from rat peritoneal mast cell. Immunapharmacol. 21, 13-24   DOI   ScienceOn
8 Manning, A. M., F. P. Bell, C. L. Rosenbloom, J. G. Chosay, C. A Simmons, J. L. Northrup, R. J. Shebuski, C. J. Dunn, and D. C. Anderson. 1995. NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. J. Inflamm. 45, 283-296
9 Oh, H., H. R. Park, I. Y. Jeong, S. H. Kim, and S. K. Jo. 2002. Protective effects of Paeonia japonica against radiation-induced damage. J. Korean Assoc. Radiat. Prot. 27, 181-188
10 Papageorgiou, P. S. 2002. Clincal aspects of food allergy. Biochem. Soc. Trans. 30, 901-906   DOI   ScienceOn
11 Park, H. R., E. J. Ju, S. K. Jo, U. Jung, S. H. Kim, and S. T. Yee. 2009. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer 9, 1-10   DOI   ScienceOn
12 Park, H. R., S. H. Kim, S. T. Yee, M. W. Byun, and S. K. Jo. 2005. Effects of a herb mixture (HIM-I) on the protection of the hematopoietic-immune system and self-renewal tissues against radiation damage. J. Korean Soc. Food Sci. Nutr. 34, 605-612   DOI   ScienceOn
13 Pastore, S., E. Fanales-Belasio, C. Albanesi, LM. Chinni, A Giannetti, and G. Girolomoni. 1997. Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin. J. Clin. Invest 99, 3009-3017   DOI   ScienceOn
14 Li, G. Z., O. H. Chai, and C. H. Song. 2004. Inhibitory effect of Rubus coreanus on compound 48/80- or anti-DNP IgE-induced mast cell activation. Immune. Network 4, 100-107   DOI
15 Makowska, J. S., M. Cieslak, and M. L. Kowalski. 2009. Stem cell factor andits soluble receptor (c-kit) in serum of asthmatic patients-correlation with disease severity. BMC. Pulm. Med. 9, 27-33   DOI   ScienceOn
16 Kim, S. H., S. E. Lee, H. Oh, J. A. Yang, C. Y. Chung, J. S. Jang, Y. B. Yu, and S. K. Jo. 1999. The radioprotective effect of Kuei-Pi- Tang as a prescription of traditional Chinese medicine in mice. J. Korean Soc. Food Sci. Nutr. 28, 698-704
17 Kim, S. H., M. R. An, S. Y. Nah, J. H. Lee, J. H. Kim, S. K. Jo, S. J. Jang, and D. H. Shin. 2001. The effects of herbs on the radiation-induced apoptosis in intestinal crypt cells. J. Korean Assoc. Radiat. Prot. 26, 27-33
18 Kim, S. H., H. Oh, S. R. Kim, S. K. Jo, M. W. Byun, K. S. Kim, J. H. Lee, and D. H. Shin. 2001. The radioprotective effects of radices herbs. Korea J. Vet. Res. 41, 105-111
19 Kim, S. H., H. Oh, E. S. Lee, S. K Jo, and M. W. Byun. 1998. Effect of Si-Wu-Tang and Si-Jun-Zi-Tang on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. Korean J. Food Sci. Technol. 30, 888-894
20 Kim, S. H., D. K. Kim, B. S. Chae, and T. Y. Shin. 2003. Inhibitory effect of Isodon japonicus Hara on mast cell-mediated immediate-type allergic reaction. Kor. J. Pharmacogn. 34, 132-137
21 Lee, S. W., Y. M. Ye, J. H. Choi, S. H. Kim, C. H. Suh, and D. H. Nahm. et al. 2004. Measurement of serum tryptase in the diagnosis of systemetic allergic reaction. Korean J. Med. 67, 185-189
22 Lee, S. E., H. Oh, J. A. Yang, S. K. Jo, M. W. Byun, S. T. Yee, and S. H. Kim. 1999. Radioprotective effects of two traditional Chinese medicine prescriptions: Si-Wu-Tang and Si-Jun-Zi-Tang. Am. J. Chin. Med. 27, 387-396   DOI   ScienceOn
23 Lee, M. S., Y. G. Ryu, O. K. Chai, K. J. Kang and J. Y. Lee. 1999. Inhibitory effect of polysaccharide fraction from Cortex mori on compound 48/80-induced mast cell activation. Korean J. Immunol. 21, 35-45
24 Erchler, W. B. and E. T. Keller. 2000. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51, 245-270   DOI   ScienceOn
25 Harada, A., N. Mukaida, and K. Matsushima. 1996. Interleukin 8 as a novel target for intervention theraphy in acute inflammatory disease. Mol. Med. Today 2, 482-489   DOI   ScienceOn
26 Jo, S. K., Y. B. Yu, H. Oh, S. R. Kim, and S. H. Kim. 2000. The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice. J. Korean Soc. Food Sci. Nutr. 29, 93-98   과학기술학회마을
27 Jo, S. K., H. R. Park, U. H. Jung, H. Oh, S. H. Kim, and S. E. Lee. 2005. Protective effect of a herbal preparation (HemoHIM) on the self-renewal tissues and immune system against $\gamma$-Irradiation. J. Korean Soc. Food Sci. Nutr. 34, 805-813   DOI   ScienceOn
28 Kang, K. J., B. D. Jun, O. H. Chai, and M. S. Lee. 1993. Inhibitory effects of Mori cortex on compound 48/80-induced histamine release and calcium uptake of rat peritoneal mast cells. Korean J. Immunol. 15, 91-99
29 Kang, O. K., H. S. Chae, J. H. Choi, H. J. Choi, P. S. Park, S. H. Cho, G. H. Lee, H. Y. So, Y. K. Choo, O. H. Kweon, and D. Y. Kwon. 2006. Effect of the Schisandra fructus water extract on cytokine release from human mast cell line. J. Med. Food 9, 480-486   DOI   ScienceOn
30 Kay, A. B. 2006. The role of T lymphocyte in asthma. Chem. Immunol. Allergy 91, 59-75
31 Kim, S. H., S. E. Lee, H. Oh, S. R. Kim, S. T. Yee, Y. B. Yu, M. W. Byun, and S. K. Jo. 2002. The radioprotective effects of Bu- Zhong-Yi-Qi-Tang: A prescription of traditional Chinese medicine. Am. J. Chin. Med. 30, 127-137   DOI   ScienceOn
32 Arend, W. P. and J. M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis Rheum. 38, 151-160   DOI   ScienceOn
33 Barnes, P. J. and I. Adcock. 1993. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Phannacol. Sci. 14, 436-441   DOI   ScienceOn
34 Butler, D. M., R. N. Maini, M. Feldmann, and F. M. Brennan. 1995. Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur. Cytokine Netw. 6, 225-230
35 Caufield, J. P., R. A. Lois, A. Hein, and K. F. Austen. 1980. Secretion in dissociated human plumanary mast cells. Evidence for solubilization of granule contents before discharge. J. Cell BioI. 85, 29-37