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http://dx.doi.org/10.5352/JLS.2009.19.12.1794

Effects of Soluble Collagen Peptides Extract Derived from Mugil cephalus Scale on the Blood Glucose and Lipid Metabolism in Diabetic Rats  

Kim, Han-Soo (Dept. of Food Science & Technology, Pusan National University)
Yoon, Ho-Dong (Food & Safety Research Center, National Fisheries Research & Development Institute)
Seong, Jong-Hwan (Dept. of Food Science & Technology, Pusan National University)
Lee, Young-Guen (Dept. of Food Science & Technology, Pusan National University)
Xie, Cheng-Liang (Dept. of Food Science & Technology, Pusan National University)
Kim, Su-Ha (Dept. of Food Science & Technology, Pusan National University)
Choi, Woo-Seok (Dept. of Food Science & Technology, Pusan National University)
Publication Information
Journal of Life Science / v.19, no.12, 2009 , pp. 1794-1801 More about this Journal
Abstract
This study was conducted to examine the effects of soluble collagen peptides extract supplementation on the improvement of blood glucose, lipid components and enzyme activities in the sera of streptozotocin (STZ, 55 mg/kg BW, IP injection)-induced diabetic rats fed on experimental diets for 5 weeks. The concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, triglycerides (TG) and phospholipids (PL) in serum were remarkably higher in the diabetic group (group SW) and STZ (IP)+collagen peptides extract supplementation group (group SFW) than those in the control group (group CG, basal diet + water). However the concentrations of blood glucose, total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free cholesterol, cholesteryl ester ratio, TG and PL in serum were lower in the SFW group than in the SW group, whereas the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration in the SFW group were higher than in the SW group. The activities of alkaline phosphatase (ALP) and aminotransferase (AST, ALT) in serum were lower in the SFW group than in the diabetic SW group. The results shown above suggest that soluble collagen peptides extract supplementation effectively improves blood glucose, lipid compositions and enzyme activities in the sera of STZ induced diabetic rats.
Keywords
Collagen peptides; diabetes; blood glucose; lipid components; enzyme activity;
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