Browse > Article
http://dx.doi.org/10.5352/JLS.2009.19.10.1456

Increase of the D-chiro-inositol and D-Pinitol Contents by Abiotic Stress in the Buckwheat Seedlings  

Ahn, Chul-Hyun (Department of Bioscience and Biotechnology, University of Suwon)
Park, Phun-Bum (Department of Bioscience and Biotechnology, University of Suwon)
Publication Information
Journal of Life Science / v.19, no.10, 2009 , pp. 1456-1462 More about this Journal
Abstract
D-chiro-Inositol, which is the isomer of myo-inositol, is a well known drug for the treatment of type II diabetes. The methylated form of D-chiro-inositol, D-pinitol and D-chiro-inositol are synthesized when the plants are exposed to the abiotic stresses such as drought, salinity and low temperature as osmoprotectants. In soybean, myo-inositol is converted to ononitol by O-methyltransferase, and ononitol is converted to D-pinitol by ononitol epimerase and finally converted to D-chiro-inositol by demethylase. However there have been some reports that in buckwheat, myo-inositol can be converted to D-chiro-inositol directly. This study was conducted to determine the changes of soluble cyclitols in buckwheat seedlings after exposure to salt and drought stresses by GC-FID. The results indicated that myo-inositol may be the precursor of D-chiro-inositol biosynthesis.
Keywords
D-chiro-inositol; D-pinitol; abiotic stress; buckwheat;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Sheveleva, E., W. Chmara, H. Bohnert, and R. G. Jensen. 1997. Increased salt and drought tolerance by D-ononitol production in transgenic Nicotiana Tabacum L. Plant Physiol. 115, 1211-1219   DOI
2 Ishitani, M., A. L. Majumder, A. Bornhouser, C. B. Michalowski, R. G. Jensen, and H J. Bohnert. 1996. Coordinate transcriptional induction of myo-inositol metabolism during environmental stress. Plant J. 9, 537-548   DOI   ScienceOn
3 Kim, J. I., J. C. Kim, M. J. Kang, M. S. Lee, J. J. Kim, and J. J. Chao 2004. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus: a Eur. J. Clin. Nutr. 59, 456-458
4 Kennigton, A. S., C. R. Hilt J. Craig, C. Bogardus, I. Raz, H. K. Ortmeyer, B. C. Hansen, G. Romero, and J. Lamer. 1990. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. New Eng. J. Med. 323, 373-378   DOI   ScienceOn
5 Lamer, J. 2001. D-chiro-inositol in insulin action and insulin resistance. IUBMB Life 51, 139-148   DOI   ScienceOn
6 Louis, P. and E. A. Galinski. 1997. Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halaphilus and osmoregulated expression in E. coli. Microbiol. 143, 1141-1149
7 Loewus, F. A. and P. P. N. Murthy. 2000. myo-Inositol metabolism in plants. Plant Sci. 150, 1-19   DOI   ScienceOn
8 Ma, J. M., M. Horbowicz, and R. L. Obendorf. 2005. Cyclitol galactosides in embryos of buckwheat stem - leaf - seed explants fed D-chiro-inositot myo-inositol or D-pinito1. Seed Sci. Res. 15, 329-331   DOI   ScienceOn
9 McCue, K. F. and A. D. Hanson. 1990. Drought and salt tolerance: Towards understanding and application. Biotechnol. 8, 358-362   DOI
10 Niu, X., R. A. Bressan, P. M. Hasegawa, and J. M. Pardo. 1995. Ion homeostasis in NaCl stress environments. Plant Physiol. 109, 735-742
11 Adams, P., J. C. Thomas, D. M. Vemon, H. Bohnert, and R. G. Jensen. 1992. Distinct cellular and organismic responses to salt stress. Plant and Cell Physiol. 33, 1215-1223
12 Boyer, J. S. 1982. Plant productivity and environment. Science 218, 443-448   DOI   ScienceOn
13 Delauney, A. J. and D. P. S. Verma. 1993. Proline biosynthesis and osmoregulation in plants. Plant J. 4, 215-223   DOI   ScienceOn
14 Gomes, C. I., R. L. Obendorf, and M. Horbowicz. 2005. myo-Inositot D-chiro-inositot and D-pinitol synthesis, transport, and galactoside formation in soybean explants. Crap Sci. 45, 1312-1319   DOI   ScienceOn
15 Hasegawa, P. M., R. A. Bressa, J. K. Zhu, and H Bohnert. 2000. Plant cellular and molecular responses to high salinity. Annu. Rev. Plant Physiol. Plant Mol. BioI. 51, 463-499   DOI   ScienceOn
16 Hong, Y. and Y. Pak. 2005. Effect of chiro-inositol from soybean on reducing hyperglycemia and its role for nutraceutic supplement for insulin resistance. Journal of Life Science 15, 197-201   DOI   ScienceOn
17 Horbowicz, M., P. Brenac, and R. L. Obendorf. 1998. Fagopyritol B1, O-alpha-D-galactopyranosyl-(1-2)-D-chiroinositot a galactosyl cyclitol in maturing buckwheat seeds associated with desiccation tolerance. Planta 205, 1-11   DOI   ScienceOn
18 Horbowicz, M., and R. L. Obendorf. 1994. Seed desiccation tolerance and storability: Dependence on flatulenceproducing oligosaccharides and cyclitols-review and survey. Seed Sci. Res. 4, 385-405
19 Flowers, T. J., P. F. Troke, and A. R. Yeo. 1977. The mechanism of salt tolerance in halophytes. Annu. Rev. Plant Physiol. 28, 89-121   DOI   ScienceOn
20 Steadman, K. J., M. S. Burgoon, R. L. Schuster, B. A. Lewis, S. E. Edwardson, and R. L. Obendorf. 2000. Fagopyritols, D-chiro-inositol, and other soluble carbohydrates in buckwheat seed milling fractions. J. Agric. Food Chem. 48, 2843-2847   DOI   ScienceOn
21 Streeter, J. G., D. G. Lohnes, and R. J. Fioritto. 2001. Patterns of pinitol accumulation in soybean plants and relationships to drought tolerance. Plant Cell and Environ. 24, 429-438   DOI   ScienceOn
22 Sze, H., X. Li, and M. G. Palmgren. 1999. Enegrization of plant cell membranes by $H^+$-pumping ATPases: Regulation and biosynthesis. Plant Cell 11, 677-689   DOI   ScienceOn
23 Taylor, S. I., D. Accili, and Y. Imai. 1994. Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM. Diabetes 43, 735-740   DOI
24 Vernon, D. N. and H. J. Bohnert. 1992. A novel methyl transferase induced by osmotic stress in the facultative halophyte Mesembryanthemum crystallinum. EMBO. J. 11, 2077-2085   DOI   ScienceOn
25 Vernon, D. M. and H. J. Bohnert. 1992. Increased expression of a myo-Inositol methyl transferase in Mesembryanthemum crystallinum is part of a stress response distinct from crassulacean acid metabolism induction. Plant Physiol. 99, 1695-1698   DOI   ScienceOn
26 Vernon, D. M., J. A. Ostrem, and H. J. Bohnert. 1993. Stress perception and response in a facultative halophyte: The regulation of salinity-induced genes in Mesembryanthemum crystallinum. Plant Cell Environ. 16, 437-444   DOI   ScienceOn
27 Yancey, P. H., M. E. Clark S. C. Hand, R. D. Bowlus, and G. N. Somero. 1982. Living with water stress: evolution of osmolyte systems. Science 217, 1214-1222   DOI
28 Yoshida, K.T., T. Fujiwara, and S. Naito. 2002. The synergistic effects of sugar and abscisic acid on myo-inositol-1-phosphate synthase expression. Physiol. Plant 114, 581-587   DOI   ScienceOn
29 Nelson, D. E., G. Rammesmayer, and H. Bohnert. 1998. Regulation of cell-specific inositol metabolism and transport in plant salinity tolerance. Plant Cell 10, 753-764   DOI   ScienceOn
30 Ono, H., K. Sawada, N. Khunajakr, T. Tao, M. Yamamoto, M. Hiramoto, A. Shinmyo, M. Takano, and Y. Murooka. 1999. Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata. J. Bact. 181, 91-99
31 Ortmeyer, H. K., L. C. Huang, L. Zhang, B. C. Hansen, and J. Lamer. 1993. Acute effects of D-chiro-inositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistance rhesus monkeys. Endocrinol. 132, 646-651   DOI   ScienceOn
32 Pak, Y., C. R. Paule, Y. D. Bao, L. C. Huang, and J. Lamer. 1993. Insulin stimulates the biosynthesis of chiro-inositol obtaining phospholipids in a rat fibroblast line expressing the human insulin receptor. Proc. Natl. Acad. Sci. USA 90, 7759-7763   DOI   ScienceOn
33 Romero, G. and J. Lamer. 1993. Insulin mediators and the mechanism of insulin action. Adv. Pharm. 24, 21-59   DOI
34 Romero, G., L. Luttrell, A. Rogot K Zeller, E. Hewlett, and J. Lamer. 1998. Phosphatidylinositol-glycan anchors of membrane proteins: Potential precursors of insulin mediators. Science 240, 509-511
35 Shen, B., R. G. Jensen, and H. Bohnert. 1997. Increased resistance to oxidative stress in transgenic plants by targeting mannitol biosynthesis to chloroplasts. Plant Physiol. 113, 1177-1183   DOI   ScienceOn