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http://dx.doi.org/10.5352/JLS.2008.18.8.1147

Effect of Trans Fat on Lipid Profiles and Fatty Acid Composition in Serum, Heart, Liver and Kidney in Mice  

Jang, Joo-Ri (Division of Marine Environment & Bioscience, Korea Maritime University)
Lim, Sun-Young (Division of Marine Environment & Bioscience, Korea Maritime University)
Publication Information
Journal of Life Science / v.18, no.8, 2008 , pp. 1147-1153 More about this Journal
Abstract
The purpose of this investigation was to determine the effect of feeding trans fat on serum and tissue lipid profiles and fatty acid composition in mice. Forty-five male mice aged at 4 weeks were fed on the 10% palm oil (n-3 deficient group), 20% dried mackerel (n-3 adequate group) and 5% trans fat (trans group) for three months. Total triglyceride, cholesterol and LDL-cholesterol levels were increased in serum, liver and heart of the n-3 deficient and trans groups compared with the n-3 adequate group, while liver HDL-cholesterol levels were lowest in the trans group (p<0.05). In liver and heart, trans group showed higher levels of total cholesterol and LDL-cholesterol compared with the n-3 deficient group (p<0.05). In fatty acid compositions of serum, heart, liver and kidney, the intake of trans fat led to increased percentages of 18:1n-9trans and 18:2n-6trans. The trans group showed similar patterns to the n-3 deficient group, except an increased percentage of 18:2n-6cis. Generally, the n-3 deficient and trans groups showed increased percentages of n-6 fatty acids and decreased percentages of n-3 fatty acids, specially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) compared to the n-3 adequate group (p<0.05). These results indicate that intake of trans fat increased total triglyceride, cholesterol and LDL-cholesterol levels, which may affect risk for cardiovascular mortality.
Keywords
Trans fat; triglyceride; total cholesterol; LDL-cholesterol; HDL-cholesterol; fatty acid composition;
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