Genistein-induced Growth Inhibition was Associated with Inhibition of Cyclooxygenase-2 and Telomerase Activity in Human Cancer Cells.
![]() |
Kim, Jung-Im
(Department of Biochemistry, Dongeui University College of Oriental Medicine)
Kim, Seong-Yun (Department of Biomaterial Control (BK21 program), Dongeui University Graduate School) Seo, Min-Jeong (Department of Biotechnology, College of Natural Resources and Life Science and BK21 Center for Silver-Bio Industrialization, Dong-A University) Lim, Hak-Seob (Bioinstitute, Millennium Promise Co., LTD) Lee, Young-Choon (Department of Biotechnology, College of Natural Resources and Life Science and BK21 Center for Silver-Bio Industrialization, Dong-A University) Joo, Woo-Hong (Department of Biology, Changwon National University) Choi, Byung-Tae (Department of Anatomy, Graduate School of Oriental Medicine, Pusan National University) Jeong, Yong-Kee (Department of Biotechnology, College of Natural Resources and Life Science and BK21 Center for Silver-Bio Industrialization, Dong-A University) Choi, Yung-Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine, Department of Biomaterial Control (BK21 program), Dongeui University Graduate School) |
1 | Adlercreutz, H. 1990. Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand. J. Clin. Lab. Invest. 201, 3S-23S |
2 | Cerni, C. 2000. Telomeres, telomerase, and myc. An update, Mutat. Res. 462, 31-47 |
3 | Choi, Y. H., L. Zhang, W. H. Lee and K. Y. Park. 1998. Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells. Int. J. Oncol. 13, 391-396 |
4 | Gescher, A. J., R. A. Sharma and W. P. Steward. 2001. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol. 2, 371-379 DOI ScienceOn |
5 | Narayan, S., A. S. Jaiswal, A. S. Multani and S. Pathak. 2001. DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2. Br. J. Cancer 85, 898-901 DOI ScienceOn |
6 | Peterson, G. and S. Barnes. 1993. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 22, 335-345 DOI ScienceOn |
7 | Su, S. J., T. M. Yeh, W. J. Chuang, C. L. Ho, K. L. Chang, H. L. Cheng, H. S. Liu, H. L. Cheng, P. Y. Hsu and N. H. Chow. 2005. The novel targets for anti-angiogenesis of genistein on human cancer cells. Biochem. Pharmacol. 69, 307-318 DOI ScienceOn |
8 |
Surh, Y. J., K. S. Chun, H. H. Cha, S. S. Han, Y. S. Keum, K. K. Park and S. S. Lee. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF- |
9 | Thun, M. J., S. J. Henley and C. Patrono. 2002. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. 94, 252-266 DOI ScienceOn |
10 | Chinni, S. R., S. A. Alhasan, A. S. Multani, S. Pathak and F. H. Sarkar. 2003. Pleotropic effects of genistein on MCF-7 breast cancer cells. Int. J. Mol. Med. 12, 29-34 |
11 | Choi, W. Y., C. Park, K. M. Kim, M. H. Han, Y. H. Choi and W. H. Lee. 2006. Induction of G2/M arrest by genistein in human AGS gastric carcinoma and SK-MEL-2 melanoma cells. Cancer Prev. Res. 11, 311-320 |
12 | Messina, M. and S. Barnes. 1991. The role of soy products in reducing risk of cancer. J. Natl. Cancer Inst. 83, 541-546 DOI |
13 | Choi, Y. H., W. H. Lee, K. Y. Park and L. Zhang. 2000. p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn. J. Cancer Res. 91, 164-173 DOI |
14 | Hwang, J. T., J. Ha and O. J. Park. 2005. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. Biochem. Biophys. Res. Commun. 332, 433-440 DOI ScienceOn |
15 | Gu, Y., C. F. Zhu, H. Iwamoto and J. S. Chen. 2005. Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World J. Gastroenterol. 11, 6512-6517 DOI |
16 | Barnes, S. 1995. Related Effect of genistein on in vitro and in vivo models of cancer. J. Nutr. 125, 777-783 |
17 | Kyo, S. and M. Inoue. 2002. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy. Oncogene 21, 688-697, 2002 DOI ScienceOn |
18 | Jin, C. Y., C. Park, J. Cheong, B. T. Choi, T. H. Lee, J. D. Lee, W. H. Lee, G. Y. Kim, C. H. Ryu and Y. H. Choi. 2007. Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3. Cancer Lett. 257, 56-64 DOI ScienceOn |
19 | Setchell, K. D. 1998. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am. J. Clin. Nutr. 68, 1333-1346 DOI |
20 | Okura, A., H. Arakawa, H. Oka, T. Yoshinari and Y. Monden. 1988. Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells. Biochem. Biophys. Res. Commun. 157, 183-189 DOI ScienceOn |
21 | Poole, J. C., L. G. Andrews and T. O. Tollefsbol. 2001. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene 269, 1-12 DOI ScienceOn |
22 | Ogawara, H., T. Akiyama, J. Ishida, S. Watanabe and K. Suzuki. 1986. A specific inhibitor for tyrosine protein kinase from Pseudomonas. J. Antibiot. (Tokyo) 39, 606-608 DOI |
23 | Ismail, I. A., K. S. Kang, H. A. Lee, J. W. Kim and Y. K. Sohn. 2007. Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation. Eur. J. Pharmacol. 575, 12-20 DOI ScienceOn |
24 | Huang, J., M. Nasr, Y. Kim and H. R. Matthews. 1992. Genistein inhibits protein histidine kinase. J. Biol. Chem. 267, 15511-15515 |
25 | Bises, G., E. Bajna, T. Manhardt, W. Gerdenitsch, E. Kallay and H. S. Cross. 2007. Gender-specific modulation of markers for premalignancy by nutritional soy and calcium in the mouse colon. J. Nutr. 137, 211S-215S DOI |
26 | Kim, J. I., C. Park, B. T. Choi, C. H. Rhu, W. H. Lee and Y. H. Choi. 2006. Induction of apoptosis by genistein through caspase-3 activation in human gastric carcinoma and melanoma cells. Cancer Prev. Res. 11, 225-234 |
27 | Alhasan, S. A., O. Aranha and F. H. Sarkar. 2001. Genistein elicits pleiotropic molecular effects on head and neck cancer cells. Clin. Cancer Res. 7, 4174-4181 |
28 | Giercksky, K. E. 2001. COX-2 inhibition and prevention of cancer. Best Pract. Res. Clin. Gastroenterol. 15, 821-833 DOI ScienceOn |
29 | Kim, E. K., Y. H. Myong, K. S. Song, K. H. Lee, C. H. Rhu and Y. H. Choi. 2006. Induction of G2/M arrest of the cell cycle by genistein in human bladder carcinoma and leukemic cells. J. Life Sci. 16, 589-597 과학기술학회마을 DOI ScienceOn |
![]() |