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http://dx.doi.org/10.5352/JLS.2008.18.4.503

Effect of Deep Sea Water on Cytochrome P450 1A1, Aromatase and MMP-9.  

Shon, Yun-Hee (Regional Innovation System, Intractable Disease Research Center)
Kim, Mee-Kyung (Regional Innovation System, Dongguk University)
Nam, Kyung-Soo (Regional Innovation System, Department of Pharmacology, College of Medicine, Dongguk University)
Publication Information
Journal of Life Science / v.18, no.4, 2008 , pp. 503-508 More about this Journal
Abstract
Deep sea water from the East sea was tested for breast cancer chemoprevention and metastasis by measuring the activities of cytochrome P450 1A1 and aromatase, invasiveness, and activity and expression of matrix metalloproteinase (MMP)-9 in breast MDA-MB-231 cancer cell. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of $100{\sim}1,000$) showed a hardness-dependent inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced cytochrome P450 1A1 activity. Deep sea water showed 27.1, 45.4 and 51.9% inhibition of microsomal aromatase activity at the hardness of 600, 800 and 1,000, respectively. In addition deep sea water inhibited not only the invasiveness of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MDA-MB-231 cells through matrigel-coated membrane in a hardness-dependent manner but also the activity and expression of MMP-9 in MDA-MB-231 cell.
Keywords
Deep sea water; cytochrome P450 1A1; aromatase; matrix metalloproteinase; breast cancer chemoprevention;
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