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http://dx.doi.org/10.5352/JLS.2008.18.3.291

Alterations of Heart Rate Variability upon β3-Adrenergic Receptor Polymorphism and Combined Capsaicin, Sesamin, and L-Carnitine in Humans  

Shin, Ki-Ok (Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Research Institute of Physical Education & Sport Science, Pusan National University)
Kim, Hyun-Jun (Laboratory of Exercise physiology, Department of Physical Education, Pusan National University)
Kang, Sung-Hwun (Department of Pharmacology, Medical Sciences Research Institute, College of Medicine, Dong-A University)
Publication Information
Journal of Life Science / v.18, no.3, 2008 , pp. 291-297 More about this Journal
Abstract
We investigated whether 1) the combined capsaicin (75 mg), sesamin (30 mg), and L-carnitine (900 mg) (CCSC) ingestion enhances autonomic nervous system (ANS) activities including thermogenic sympathetic activity as energy metabolic modulator, 2) ${\beta}_3-AR$ polymorphism of each subject influences with ANS activity. Seven healthy males $(22.0{\pm}0.5\;yr)$ volunteered for this study. The cardiac autonomic nervous activities evaluated by means of heart rate variability of power spectral analysis were continuously measured during 5 min every 30 min for total 120 min resting condition with CCSC or placebo oral administration chosen at random. The results indicated that, there are not $Arp/Arg^{64}$ variants of the ${\beta}_3-AR$ genotypes in our subjects. There were not also significant differences in heart rate during rest between both trials. The difference of ANS activity did not reach the statistical significance between both trials. However, the significant improvement showed TOTAL power, HF component, and the indices of SNS and PNS activities before and at 30 min after CCSC ingestion (p<0.05, respectively). In conclusions, although each component of combined CCSC is associated with lipolysis and/or fat oxidation, the combined CCSC consumption is not influenced in stimulation of thermogenic sympathetic activity as modulator of energy metabolism. In rather, our results suggested that CCSC ingestion improves the balance of both SNS and PNS activities. Therefore, it will be considered many combined nutrient components for ergogenic and/or lipolysis effects as well as genetic variants affecting ANS activity in further studies.
Keywords
Autonomic nervous system; heart rate variability${\beta}3-AR$; combined capsaicin; sesamin; L-carnitine;
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