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http://dx.doi.org/10.5352/JLS.2008.18.2.249

The Effect of Sea Tangle Extract on Serum Lipid Level in Ovariectomized Rats  

Lee, Young-Ae (Dept. of Food Science and Nutrition, Silla University)
Kim, Mi-Hyang (Dept. of Food Science and Nutrition, Silla University)
Publication Information
Journal of Life Science / v.18, no.2, 2008 , pp. 249-254 More about this Journal
Abstract
This study was performed to investigate the effects of sea tangle (ST) extracts on serum lipid concentration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with ST at 50 mg/kg body wt (OVX-ST50) and ovariectomized rats supplemented with ST at 200 mg/kg body wt (OVX-ST200). The activities of serum GOT and GPT were increased by ovariectomized. The serum GOT levels in OVX-ST50 and OVX-ST200 groups were decreased than OVX-control group. But GPT level was only decreased in the serum of OVX-ST200 group. Serum total cholesterol and triglyceride contents decreased in sham group compared with OVX-control group by ovariectomy. Six weeks feeding of ST extract resulted in a significant lowering of serum triglyceride and lowering tendency of total cholesterol Level. The serum HDL-cholesterol was higher in ST groups than OVX-control group. These results suggest that the beneficial effect of ST extract may be used to possibly improve on the lipid metabolic syndrome of menopausal women.
Keywords
Sea tangle; ovariectomized rat; lipid metabolism; postmenopausal;
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