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http://dx.doi.org/10.5352/JLS.2008.18.1.023

Ginsenosides Protect the High Glucose-induced Stimulation of IGFs in Mesangial Cells  

Bae, Chun-Sik (College of Veterinary Medicine, Biotechnology Research Institute,Chonnam National University)
Lim, Do-Seon (Department of Dental Hygiene, Eulji University)
Yoon, Byeong-Cheol (College of Veterinary Medicine, Biotechnology Research Institute,Chonnam National University )
Jeong, Moon-Jin (Department of Oral Histology, College of Dentistry, Chosun University)
Yoon, Kyung-Chul (Department of Ophthalmology, Chonnam National University, Medical School and Hospital)
Park, Soo-Hyun (Functional Food Center, Chonnam National University)
Publication Information
Journal of Life Science / v.18, no.1, 2008 , pp. 23-29 More about this Journal
Abstract
Panax ginseng C. A. MEYER is one of the most widely used herbal medicines in the Asian countries and has diverse functions including anti-diabetic action. The dysfunctions of mesangial cells in hyperglycemic conditions are implicated in the development of diabetic nephropathy. Insulin-like growth factors (IGFs) are also associated with the onset of diabetic nephropathy. Thus, we examined the effect of ginsenosides against high glucose-induced dysfunction of primary cultured rat mesangial cells. In the present study, high glucose increased IGF-I and IGF-II secretion in mesangial cells. Ginsenoside total saponin (GTS) prevented high glucose-induced increase of IGF-I and IGF-II secretion in mesangial cells. In addition, GTS prevented high glucose-induced increase of lipid peroxide formation and decrease of GSH contents. GTS also ameliorates high glucose-induced increase of arachidonic acid release and decrease of prostaglandin $E_2$. In conclusion, GTS prevented high glucose-induced dysfunction of mesangial cells via inhibition of oxidative stress and arachidonic acid pathways.
Keywords
Ginsensides; mesangial cells; high glucose; diabetic nephropathy; insulin-like growth factor-1;
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