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http://dx.doi.org/10.5352/JLS.2008.18.11.1493

Factors Affecting the Postoperative Outcome in Adult Cardiac Surgery with Cardiopulmonary Bypass  

Lee, Sung-Chul (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Kim, Yun-Tae (Seoul Medical Science Institute (SMSI))
Moon, Seong-Min (Department of Biomedical Laboratory of Science, College of Smart Foods and Drugs, Inje University)
Hyun, Kyung-Yae (Department of Biomedical Laboratory of Science, College of Smart Foods and Drugs, Inje University)
Kim, Dae-Sik (Department of Clinical Laboratory Science, Dongnam health college)
Choi, Seok-Cheol (Seoul Medical Science Institute (SMSI))
Publication Information
Journal of Life Science / v.18, no.11, 2008 , pp. 1493-1498 More about this Journal
Abstract
We defined factors affecting the postoperative outcome in adult cardiac surgery with cardiopulmonary bypass (CPB). Thirty-two adult patients scheduled for elective cardiac surgery participated in this study. Levels of leukocyte, glutamic oxaloacetic transaminase (GOT), troponin-I (cTNI), interleukin-6 (IL-6), D-dimer and neuron-specific enolase (NSE) were significantly elevated, whereas platelet count declined in cardiac surgery with CPB. GOT and D-dimer levels at CPB-off each had a positive significant correlation significantly with 24 hrs-bleeding, total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. BUN levels at CPB-off were directly related to total bleeding, mechanical ventilatory assist time, ICU stay time and length of hospitalization. Platelet count at CPB-off was inversely related to mechanical ventilatory assist time, ICU stay time and length of hospitalization. Creatinine concentration at CPB-off interrelated positively with mechanical ventilatory assist time and ICU stay time. NSE levels at CPB-off had a positive relationship with postoperative 24 hrs-bleeding. The length of hospitalization was prolonged proportionally to the elevation of cTNI levels in cardiac surgery. Aortic cross-clamping and total CPB times also related with increase of 24 hrs and total bleeding volumes and the length of hospitalization. IL-6 and ET-1 had no mutual relation with any postoperative outcome. These data suggest that GOT, BUN, creatinine, D-dimer and platelet levels are the most important factors affecting postoperative outcomes and patient's recovery in adult cardiac surgery with CPB.
Keywords
Adult cardiac surgery; cardiopulmonary bypass; postoperative outcomes;
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