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http://dx.doi.org/10.5352/JLS.2007.17.6.847

Endoplasmic Reticulum Signaling for Recombinant-protein Production  

Goo, Tae-Won (Department of Agricultural Biology, Rural Development Administration)
Yun, Eun-Young (Department of Agricultural Biology, Rural Development Administration)
Kang, Seok-Woo (Department of Agricultural Biology, Rural Development Administration)
Kwon, Ki-Sang (Department of Anatomy, College of Medicine, Chungnam National University)
Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
Publication Information
Journal of Life Science / v.17, no.6, 2007 , pp. 847-858 More about this Journal
Abstract
The endoplasmic reticulum (ER) is an important intracellular organelle for folding and maturation of newly synthesized transmembrane and secretory proteins. The ER provides stringent quality control systems to ensure that only correctly folded proteins exit the ER and unfolded or misfolded proteins are retained and ultimately degraded. The ER has evolved stress response both signaling pathways the unfolded protein response (UPR) to cope with the accmulation of unfolded or misfolded proteins and ER overload response (EOR). Accumulating evidence suggests that, in addition to responsibility for protein processing, ER is also an important signaling compartment and a sensor of cellular stress. In this respect, production of bio-functional recombinant-proteins requires efficient functioning of the ER secretory pathway in host cells. This review briefly summarizes our understanding of the ER signaling developed in the recent years to help of the secretion capacities of recombinant cells.
Keywords
Endoplasmic reticulum (ER) stress; recombinant-protein; unfolded protein response (UPR); ER overload response (EOR); chaperone; ER quality control (ERQC); glycosylation;
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