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http://dx.doi.org/10.5352/JLS.2007.17.4.575

The Effect of Mulberry Fruits Extracts on Blood Flow Improvement in Ovariectomized Rats  

Choi, Kyung-Ha (Chenho Food)
Shon, Jae-Hak (Dept. of Bio-food Material Science, Silla University)
Choi, In-Soon (Dept. of Biological Science, Silla University)
Choi, Young-Ju (Dept. of Food and Nutrition, Silla University)
Bae, Song-Ja (Dept. of Food and Nutrition, Silla University)
Kim, Mi-Hyang (Dept. of Food and Nutrition, Silla University)
Publication Information
Journal of Life Science / v.17, no.4, 2007 , pp. 575-580 More about this Journal
Abstract
The purpose of this study was to investigate the effect of three different mulberry cultivars extracts on inhibition of platelet aggregation and blood flow improvement. Four groups were surgically ovariectomized (OVX). The fifth group was sham operated. Sprague-Dawley strain female rats were randomly assigned to the following groups. sham-operated rats(Sham), ovariectomized control rats(OVX-Control), ovariectomized rats supplemented with 80% ethanol extracts from fruits of Tajikistan mulberry (OVX-TM), Korea mulberry (OVX-KM) and China mulbery (OVX-CM) at 200 mg/kg bw/d. The mulberry extracts were orally administrated at 1 ml per day. The body weights of OVX rats were significantly heavier than the sham-operated rats at all values (p<0.05). The serum triglyceride level was significantly decreased after supplemented with the CM and KM extracts. The serum HDL-cholesterol level in the OVX-KM group was significantly higher than that in the OVX-control group. The passage time of whole blood showed significant correlation with triglyceride but reverse correlation with HDL cholesterol. The ability of platelet aggregation of groups treated with mulberry extracts was less than OVX-control group. Taken these together, mulberry extracts may be used to possibly improve the quality of life in menopausal women.
Keywords
mulberry; blood passage time; platelet aggregation; ovariectomized rats;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Kim, S. Y. and K. J. Park. 1998. Antiinflammatory and antioxidative effects of morus spp. fruit extract. Korean J. Medicinal Crop Sci. 6, 204-209   과학기술학회마을
2 Sabra, A. and J. Bonnar. 1983. Hemostatic system changes induced by $50{\mu}g$ and $30{\mu}g$ estrogen/progestogen oral contraceptives. Modification of estrogen effects by levonorgestrel. J. Reprod. Med. 28(1 suppl). 85-91
3 Ross, R. K., A. Pagamm-Hill, T. M. Mark and B. E. Henderson. 1989. Cardiovascular benefits of estrogen replacement therapy. Am. J. Obstet Gynecol. 160, 1301-1306   DOI   ScienceOn
4 Spiller, G. A. and R. J. Amen. 1975. Dietary fiber in human nutriation. Crit. Rev. Food Sci. Nutr. 7, 39-66   DOI   ScienceOn
5 Stadel, B. V. 1981. Oral contraceptives and cardiovascular disease(1st of 2 parts). N. Eng. J. Med. 305, 612-616   DOI   ScienceOn
6 Stolley, P. D., J. A. Tonascia. M. S. 'I'ockman, P. E. Sartwell, A. H. Rutledge and M. P. Jacobs. 1975. Thrombosis with low-estrogen oral contraceptives. Am. J. Epidem. 102, 197-201   DOI
7 Valette, A., K. M. Meignen, L. Mercier, J. G. Liehr and J. Boyer. 1986. Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat. J. Steroid Biochem. 25, 575-578   DOI   ScienceOn
8 Vessey, M. P. 1984. Oral contraceptives and stroke : Finding in a large prospective study. Br. Med. J. 289, 530-532
9 Wickelgren, I. 1997. A new weapon against Alzheimer's. Science 276, 676-677   DOI
10 Wronski, T. J., M. Cintron and L. M. Dann. 1988. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif. Tissue. Int. 43, 179-183   DOI   ScienceOn
11 Grodstein, F., M. J. Stamfer, G. A. Colditz, W. C. Willett, J. E. Manson, M. Joffe, B. Rosner, C. Fuchs, S. E. Hankinson, D. J. Hunter, C. H. Hennekens and F. E. Speizer. 1997. Postmenopausal hormone therapy and mortality. New. Engl. J. Med. 336, 1769-1775   DOI   ScienceOn
12 Kim, S. H., H. Y. Park and W. K. Park. 1988. Determination and physical properties of dietary fiber in seaweed products. J. Korean Soc, Food Sci. Nutr. 17, 320-325   과학기술학회마을
13 Kim, H. B., G. J. Bark, Y. S. Seok, S. L. Kim, G. B. Sung, H. W. Nam and J. Y. Moon. 2002. Morphological characteristics and physiological effects of mulberry leaves and fruits with wild varieties, Korean Scociety of Sericultural Science 44, 4-8   과학기술학회마을
14 Kim, H. B., S. Y. Kim, G. S. Rue, Y. J. Lee and J. Y. Moon. 2001. Effect of methanol extract from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemia rats, Korean Scociety of Sericultural Science 42, 104-108   과학기술학회마을
15 Kim, H. B, H. S. Bang, H. W. Lee, Y. S. Seuk and B. S. Gyoo. 1999. Chemical characteristics of mulberry syncarp. Korean J. Seric. Sci. 41, 123-128   과학기술학회마을
16 Kim, S. Y, W. C. Lee, H. B. Kim, A. J. Kim and S. K. Kim. 1998. Antihyperlipidemica effects of methanol extracts from mulberry leaves in cholesterol-induced hyperlipidemia rats. J. Kor. Soc. Food Sci. Nurt. 27, 1217-1222
17 Kim, T. W, Y. B. Kwon, Lee, J. H. Yang, I. S. Youm, J. K. Lee, H. S and J. Y. Moon. 1996. A study on the antidiabetic effect of mulberry fruits. Korean. J. Seric. Sci. 38, 100-107   과학기술학회마을
18 Meade, Y. W. 1982. Oral contraceptives, clotting factors, and thrombosis. Am. J. Obstet. Gynecol. 142, 758-761   DOI
19 Nakamura, H., F. Kinoshita, K. Itou, K. Mugitani, H. Oohata, M. Iwane, A. Yoshikawa and O. Mohara. 2004. Analysis of factors which relate to lifestyle related diseases observed from blood rheology. JJCDP 39, 1-4
20 Ramirez, M. E., M. P. McMurry, G. A. Wiebke, K. J. Felton and K. Ren, 1997. Evidence for sex steroid inhibition of lipoprotein lipase in men; comparison of abdominal and femoral adipose tissue. Metabolism 46, 179-185   DOI   ScienceOn
21 Colditz, G. A., S. E. Hankinson, D. J. Hunter, W. C. Willett, J. E. Menson, M. J. Stampfer, C. Hennekens, B. Rosner and F. E. Speizer. 1995. The use of estrogens and progenstins and the risk of breast cancer in postmenopausal women. New. Engl. J. Med. 332, 1589-1593   DOI   ScienceOn
22 Aitken, J. M., E. Armstrong and J. B. Anderson. 1972. Osteroporosis after ophoretomy in the mature female rat and the effect of estrogen and ovariectomy or progesterone replacement therapy in its prevention. J. Endocrinol. 55, 79-87   DOI   ScienceOn
23 Brosage, P. 1995. Hormone therapy: The woman's decision. Contemp. Nurse Pract. 1 (S), 3
24 Cecily, C. K. 1990. Clinical aspects of the relationship between oral contraceptives and abnormalities of the hemostatic system: Relation to the development of cardiovascular disease. Am. J. Obstet. Gynecol. 163, 392-395   DOI   ScienceOn
25 Cook, N. S., H. G. Zerowes, C. TapparelI, M. Pawling, J. Singh, R. Matternich and A. Hagenbach. 1993. Platelet aggregation and fibrinogen binding in human, rhesus minkey, guinea-pigs hamster and rat blood ; activation by ADP and a thrombin receptor peptide and inhibition by glycoprotein IIb/IIIa antagonist. Thrombosis and Haernostosis 70, 531-539
26 Dodds W. J. 1978. Platelet function in animals: species specificities. In platelets : Multidisciplinary Approach, ed. G. De Gaetana and S. Garattini, pp. 45-49. Raven Press, New York
27 Falk, E., P. K. Shah and V. Fuster. 1995. Coronary plaque disruption. Circulation 92, 657-671   DOI   ScienceOn
28 Abe, T., J. W. M. Chow, J. M. Lean and T. J. Chambers. 1993. Estrogen does not restore bone list after ovariectomy in the rat. J. Bone Miner. Res, 8, 831-838   DOI   ScienceOn
29 Harris, R. B., A. Laws, F. M. Reddy, A. King and W. L. Haskell. 1990. Are women using postmenopausal estrogens? A community survey. Am. J. Public Health 80, 1266-1268   DOI   ScienceOn
30 Jeong, C. H., O. S. Joo and K. H. Shim. 2002. Chemical components and physiological activities of young mulberry(Morus alba) stem. Korean journal of Food Preservation 9, 228-233   과학기술학회마을
31 Annual Report on the Cause of Death Statistics. National Statistical Office, Seoul, 1997
32 Belchetz, P. E. 1994. Hormonal treatment of postmenopausal women. N. Eng. J. Med. 330, 1062-1071   DOI   ScienceOn
33 Bush, T. L. and E. Barret-Connor. 1985. Noncontraceptive estrogen use and cardiovascular disease. Epidemiol. Rev. 7, 89-104
34 Chen, F., N. Nakashima, J. Kimura and M. Kimura. 1995. Hypoglycemic activity and mechanisms of extracts from mulberry leaves(Folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Yakugaku Zasshi 15, 476-482
35 Cha, J. Y., H. J. Kim and Y. S. Cho. 2000. Effect of water-soluble extract from leaves of Morus alba and Cudrania tricuspidata on the lipid concentrations of serum and liver in rats. J. Korean Soc. Agric. Chem. Biotechnol. 43, 303-308