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http://dx.doi.org/10.5352/JLS.2007.17.2.192

Role of Rho A and F-actin for uropod formation in T lymphocytes  

Lee, Jong-Hwan (Department of Biotechnology & Bioengineering, Dong-Eui University)
Publication Information
Journal of Life Science / v.17, no.2, 2007 , pp. 192-197 More about this Journal
Abstract
Two distinct morphological features, leading edge and uropod, in mobile T lymphocyte are crucial for efficient directional movement. The uropod is a unique rear protrusion in migrating lymphocytes, in which several proteins, including CD44, ERM (ezrin/radixin/moesin), and F-actin cytoskeleton are concentrated and concerted. F-actin cytoskeleton is a basic mold for the shape maintenance. Rho A small GTPase acts as cytoskeleton organizer, So far, various pathways potentially can induce the Rho activation. PDZ domain is able to increase active Rho A form (Rho-GTP) level, reorganize F-actin cytoskeleton, disrupts the uropod structure and cell migration was diminished, suggesting that signaling pathways between Rho and F-artin cytoskeleton are related to uropod formation.
Keywords
Uropod; Rho A; F-atctin; migration; PDZ;
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