Browse > Article
http://dx.doi.org/10.5352/JLS.2007.17.11.1593

Intestinal and Mesenteric Lymphosarcoma on Alcohol Liver Disease in the Mice  

Yuan, Dong-Wei (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Yang, Hai-Jie (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Hong, Il-Hwa (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Ki, Mi-Ran (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Park, Jin-Kyu (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Goo, Moon-Jung (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Lee, Hye-Rim (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Yoo, Seung-Eun (Korea Research Institute of Chemical Technology)
Jeong, Kyu-Shik (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Life Science / v.17, no.11, 2007 , pp. 1593-1595 More about this Journal
Abstract
In the study of investigate the expression and effects of adrenomedullin (AM) in the tissue injured by ethanol in our laboratory, there were lymphosarcomas involving mesenteric lymph node and intestine discovered in experimental mice. Lymphosarcoma is probably the second most common spontaneous neoplastic disease, the incidence of which is dependent on the strain of mouse. The diagnosis of lymphosarcoma was based on gross and light microscopic studies. Crossly, the excised intestine and mesentery showed soft-to-firm, cream-colored, displayed protuberance into the lumen. The neoplastic cells had mainly infiltrated into the mucosal and mesenteric lymph node, and have round hyperchromatic nuclei and a small amount of cytoplasm. The origin of these tumor cells was determined by immunohistochemistry positive of CD20, CD3 and Vimentin.
Keywords
Intestine; mesentery; mice; lymphosarcoma;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Nanji, A. A. and D. Zakim. 1996. Hepatology: A Textbook of Liver Disease. pp. 911-913, 3rd eds., W. B. Saunders Co., Philadelphi.
2 Radaszkiewicz, T., B. Dragosics and P. Bauer. 1992. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology 102, 1628-1638.   DOI
3 Anderson, L. J., W. F. H. Jarrett and G. W. Crighton. 1969. A classification of lymphoid neoplasms of domestic mammals. pp. 343-353, In: Lingeman, C. H. and Garner, F. M. (eds), Comparative morphology of hematopoietic neoplasms. National Cancer Insititute Monograph 32, U. S. Government Printing Office.
4 Anderson, L. J., A. T. Sandison and W. F. H. Jarrett. 1969. A British Abattoir Survey of Tumors in Cattle, Sheep and Pigs. Vet. Rec. 84, 547-551.   DOI   ScienceOn
5 Moulton, J. E. and J. W. Haevey. 1990. Tumors of the lymphoid and hematopoietic tissues. In:Tumors in domestic animals, pp. 231-307, 3rd eds., University of California Press, Berkeley, California.
6 Jack, E. M. 1978. Tumors in domestic animals. pp. 150-196, 2ed eds., The Regents of the University of California, London, England.
7 Jones, T. C., R. D. Hunt and N. W. King. 1997. Veterinary pathology, pp. 1034-1042, 6th eds., Williams and Wilkins, Baltimore, Maryland.
8 Jubb, K. V. F., P. C. Kennedy and N. Palmer. 1993. Pathology of Domestic Animals. pp. 611-612, 4th eds., Academic Press, San Diego, California.