Browse > Article
http://dx.doi.org/10.5352/JLS.2007.17.11.1488

The Ossifying Epulis Accompanying Multi-Nucleated Giant Cells in a Dog  

Hong, Il-Hwa (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Jeong, Won-Il (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Son, Young-Sook (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Park, Jin-Kyu (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Yang, Hai-Jie (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Yuan, Dong-Wei (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Goo, Moon-Jung (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Lee, Hye-Rim (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Jeong, Kyu-Shik (Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Publication Information
Journal of Life Science / v.17, no.11, 2007 , pp. 1488-1491 More about this Journal
Abstract
An epulis was occurred on gingiva of 11-year old female dog, Yorkshire terrier. Our case had feature of ossifying epulis but there were a few multi-nucleated giant cells (MGCs). MGCs had osteoclast-like appearance and giant cell epulis usually appears at the site of tooth extraction. Therefore, we suggest that appearance of MGCs in our case may be due to phagocytosis pre-formed osteoid/bone or our case may be mixed epulides of ossifying and giant cell epulis by mixed stimulation of chronic gingivitis and trauma and in flammation by tooth extraction. Thus, MGCs have possibility enough to appear in ossifying epulis, but ossifying epulis accompanying MGCs has not been reported. Therefore, our case may deserves an attention as an unique case and will be helpful to study pathogenesis of giant cell containing lesion of the jaw.
Keywords
Epulis; multi-nucleated giant cell; osteoclast;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Dubielzig, R. R., M. H. Goldschmidt and R. S. Brodey. 1979. The nomenclature of periodontal epulides in dogs. Vet. Pathol. 16, 209-214.   DOI
2 Itonaga, I., I. Hussein, O. Kudo, A. Sabokbar, S. Watt-Smith, D. Ferguson and N. Athanasou. 2003. Cellular mechanisms of osteoclast formation and lacunar resorption in giant cell granuloma of the jaw. J. Oral Pathol. Med. 32, 224-231.   DOI   ScienceOn
3 Liu, B., S. F. Yu and T. J. Li. 2003. Multinucleated giant cells in various forms of giant cell containing lesions of the jaws express features of osteoclasts. J. Oral Pathol. Med. 32, 367-375.   DOI   ScienceOn
4 Nakagawa, N., M. Kinosaki, K. Yamaguchi, N. Shima, H. Yasuda, K. Yano, T. Morinaga and K. Higashio. 1998. Rank is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem. Biophys. Res. Commun. 253, 395-400.   DOI   ScienceOn
5 Regezi, J. A. 2002. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Mod. Pathol. 15, 331-341.   DOI   ScienceOn
6 Ringler, D. J. 1997. The digestive system, pp. 1043-1109, In: Veterinary Pathology, 6th eds., Lippincott Williams & Wilkins, Baltmore.
7 Ustundag, E., M. Iseri, G. Keskin and B. Muezzinoglu. 2002. Central giant cell granuloma. Int. J. Pediatr. Otorhinolaryngol. 65, 143-146.   DOI   ScienceOn
8 Valentine, B. A. and M. A. Eckhaus. 1986. Peripheral giant cell granuloma (giant cell epulis) in two dogs. Vet. Pathol. 23, 340-341.   DOI
9 Yoshida, K., T. Yanai, T. Iwasaki, H. Sakai, J. Ohta, S. Kati, T. Minami, A. A. Lackner and T. Masegi. 1999. Clinicopathological study of canine oral epulides. J. Vet. Med. Sci. 61, 897-902.   DOI   ScienceOn
10 Barker, I. K., A. V. Van dreumel and N. Palmer. 1997. The alimentary system, pp. 22-25, In: Pathology of Domestic Animals. vol. 2. 4th eds., Academic Press Inc, San Diego.
11 Colgine, L. M. A., F. Y. Schulman and R. R. Dubielzig. 2001. Multiple epulides in 13 cats. Vet. Pathol. 38, 227-229.   DOI   ScienceOn
12 Harvey, C. E. and P. P. Emily. 1993. Periodontal disease, pp. 89-144, In: Small Animal Dentistry, Mosby, St. Louis, MO.