Browse > Article
http://dx.doi.org/10.5352/JLS.2006.16.7.1181

Antiinflammatory Effects of New Chemical Compounds, HS-1580 Series (HS-1580, HS-1581, HS-1582)  

Kim, Ji-Young (Department of Biology, College of Natural Sciences, Pusan National University)
Kim, Kyun-Ha (Department of Biology, College of Natural Sciences, Pusan National University)
Suh, Hong-Suk (Department of Chemistry, College of Natural Sciences, Pusan National University)
Choi, Won-Chul (Department of Biology, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.16, no.7, 2006 , pp. 1181-1187 More about this Journal
Abstract
HS-1580 series (HS-1580, HS-1581, HS-1582) can produce anti-imflammatory effects were synthesized from the marine algae extraction in 2,3,6-tribromo-4,5-dihydroxy benzyl methyl ether (TDB). Raw 264.7 cells were pre-treated with $1{\mu}g/{\mu}l$ lipopolysaccharide (LPS) and later treated with HS-1580 series. These cells of inflammatory mediators were tested as well. Nitric oxide (NO) is related to autoimmune disease and is produced by inducible NOS (iNOS). When treated with HS-1580 series, the product of NO will reduce in a dose-dependent manner. HS-1580 series significantly inhibit the iNOS protein expression. Cyclooxygenase (COX) involves with the various physiologic events and catalyzes in prostaglandin. HS-1580 series also inhibit the COX-2 protein expression as well as pro-inflammatory cytokines production such as tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})\;and\;interluekin-1{\alpha]\;(IL-1{\beta})$. These upcoming results suggest that HS-1580 series have anti-inflammatory efforts in Raw 264.7 cells by inhibiting such as iNOS, COX-2, $TNF-{\alpha}\;and\;IL-1{\beta}$ as inflammatory mediators.
Keywords
Raw 264.7; NO; COX-2, inflammation; HS-1580; HS-1581; HS-1582; $TNF-{\alpha}$;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Morikawa, A., Koide, N., Sugiyama, T., Mu, M. M. and Hassan, F. 2004. The enhancing action of D-galactosamine on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. FEMS Immunol. Med. Microbiol. 41, 211-218   DOI   ScienceOn
2 Mukhopadhyay, S., Srivastava, V. M. L., Murthy, P. K. and Hasnain, S. E. 2004. Poorer $NF-{\kappa}B$ signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. FEBS Lett. 567, 275-280   DOI   ScienceOn
3 Nelson, E. J., Connoly, J., and McArthur, P. 2003. Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism. Biol. Cell. 95, 3-8   DOI   ScienceOn
4 Opal, S. M. and Depalo, V. A. 2000 Anti-inflammatory cytokines. Chest 117, 1162-1172   DOI   ScienceOn
5 Otto, J. C. and Smith, W. L. 1996. Photolabeling prostaglandin endoperoxide H synthase-1 with 3-tirfluoro-(m-[$^{125}I$]iodophenyl) diazirine as probe of membrane association and the cyclooxygenase active site. J. Bio. Chem. 26, 9906-9910
6 Sakata, K., Hirose, Y., Qiao, Z., Tanaka, T. and Mori, H. 2003. Inhibition of inducible isoforms of cyclooxygenases and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett. 199, 139-145   DOI   ScienceOn
7 Schneider, C. P., Schwacha, M. G. and Chaudry, I. H. 2004. The role of interleukin-10 in the regulation of the systemic inflammatory response following trauma-hemorrhage. Biochim. Biophys. Acta 1689, 22-32   DOI   ScienceOn
8 Thomsen, L. L. and Miles, D. W. 1998. Role of nitric oxide in tumour progression: Lessons from human tumuors. Cancer Metastasis Rev. 17, 107-108   DOI   ScienceOn
9 Ju, H. K., Baek, S. H., An, R. B., Bae, K. H. and Son, K. H. 2003. Inhibitory effects of nardostachin on nitric oxide, prostaglandin $E_2$, and tumor necrosis factor-${\alpha}$ production in lipopolysaccharide activated macrophages. Biol. Pharm. Bull. 26, 1375-1378   DOI   ScienceOn
10 Ban, H. S., Suzuki, K., Lim, S. S., Jung, S. H. and Lee, S. H. 2004. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-${\alpha}$ by 2-hydroxychalcone derivatives in RAW 264.7 cells. Biochem. Pharmacol. 67, 1549-1557   DOI   ScienceOn
11 Bosca, L., Zeine, M. and Trares, P. G. 2005. Nitric oxide and cell viability in inflammatory cells; a role for NO in macrophage function and fate. Toxicology 208, 249-258   DOI   ScienceOn
12 Kim, Y. K., Kim, R. G., Park, S. J., Ha, J. H. and Choi, J. W. 2002. In vitro anti-inflammatory activity of Kaloponaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. Biol. Pharm. Bull. 25, 472-476   DOI   ScienceOn
13 Shin, K. M., Kim, Y. H., Park, W. S., Kang, I. S. and Ha, J. H. 2004. Inhibition of methanol extract from the fruits of Kochia scoparia on lipopolysaccharide-induced nitric oxide, prostaglandin $E_2$, and tumor necrosis factor-${\alpha}$ production from murine macrophage Raw 264.7 cells. Biol. Pharm. Bull. 27, 538-543   DOI   ScienceOn
14 Li, J., Simmons, D. L. and Tsang, B. K. 1996. Regulation of hen granulose cell prostaglandin production by transforming growth factors during follicular development : involvement of cyclooxygenase II. Endocrinology 137(6), 2522-2529   DOI   ScienceOn
15 Liu, G., Zhai, Q., Schaffner, D., Bradburne, C. and Wu, A. 2004. IL-15 induces IFN-${\beta}$ and iNOS gene expression, and antiviral activity of murine macrophage RAW 264.7 cells. Immunol. Lett. 91, 171-178   DOI   ScienceOn
16 Wang, C., Schuller Levis, G. B., Lee, E. B., Levis, W. R. and Lee, D. W. 2004. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-${\alpha}$ in activated RAW 264.7 cells. Int. Immunopharmacol. 4, 1039-1049   DOI   ScienceOn
17 Kamei, K. I., Haruyama, T., Mie, M., Yasuko, Y, Aizawa, M. and Kobatake, E. 2003. Development of immune cellular biosensing system for assessing chemicals on inducible nitric oxide synthase signaling activator. Anal. Biochem. 320, 75-81   DOI   ScienceOn
18 Kim, J. K., Noh, J. H., Lee, S. Choi, J. S. and Suh, H. 2002. The first total gynthesis of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (TDB) and its antioxidant activity. Bull. Korean Chem. Soc. 23, 661-662   DOI   ScienceOn
19 Kim, H. J., Jang, S. I., Kim, Y. J., Chung, H. T. and Yun, Y. G. 2004. Scopoletin suppresses pro-inflammatory cytokines and $PGE_2$ from LPS-stimulated cell line, RAW 264.7 cells. Fitoterapia 75, 261-266   DOI   ScienceOn
20 Kim, Y. H., Ko, W. S., Ha, M. S., Lee, C. H. and Choi, B. T. 2000. The production of nitric oxide and TNF-${\alpha}$ in peritoneal macrophages is inhibited by Dichroa feblifuga Lour. J. Ethnopharmacol. 69, 35-43   DOI   ScienceOn
21 Lanza-Jacoby, S., Dicker, A. P., Miller,S., Rosato, F. E. and Flynn, J. T. 2004. Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice. Mor. Cancer Ther. 3, 417-424   DOI
22 Lee, D. U., Kang, Y. J., Park, M. K., Lee, Y. S. and Seo, H. G. 2003. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II TNF-${\alpha}$, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 73, 1401-1402   DOI   ScienceOn
23 Guastadisegni, C., Nicolini, A., Balduzzi, M., Ajmone-Cat, M. A. and Minghetti, L. 2002. Modulation of $PGE_2$ and $TNF-{\alpha}$ by nitric oxide in resting and Ips-activated raw 264.7 cells. Cytokine 19, 175-180   DOI   ScienceOn
24 Miller, M. J. and Grrisham, M. B. 1995. Mediators Inflamm. 4, 387-396   DOI   ScienceOn
25 Lee, J. Y., Lee, M. H., Park, H. R., Choi, J. S., Seo, H. S., An, W. G. and Choi, W. C. 2003. Antioxidants of new compounds from maline Algae prevent cell death of endothelial cells. J. Fish Pathol. 16, 39-49
26 Chung, H. Y., Choi, H. R., Park, H. J., Choi, J. S. and Choi, W. C. 2001. Peroxinitrite scavenging and cytoprotective activity of 2,3,6-tlibromo - 4,5-dihydroxybenzyl methyl ether from the marine alga symphyocladia latiuscula. J. Arig Food Chem. 49, 3614-3621   DOI   ScienceOn
27 Cohen, R. I., Hassell, A. M., Ye, X., Marzouk, K. and Liu, S. F. 2003. Lipopolysacchalide down-regulates inducible nitric oxide synthase expression in swine heart in vivo. Biochem. Biophys. Res. Commun. 307, 451-458   DOI   ScienceOn
28 Dinarello, C. A. 2000 Proinflammatory cytokines. Chest 118, 503-508   DOI   ScienceOn
29 Hong, C. H., Hur, S. K., Oh, O-J., Kim, S. S., Nam, K. A. and Lee, S. K. 2002. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J. Ethmopharmacol. 83, 153-159   DOI   ScienceOn
30 Jhun, B. S., Jin, Q., Oh, Y. T., Kim, S. S. and Kong, Y. 2004. 5-Aminomidazole-4-carboxamide ribiside suppresses lipopolysaccharide-induced TNF-${\alpha}$ production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem. Biophys. Res. Commun. 318, 372-380   DOI   ScienceOn
31 Wu, D., and Meydani, S. N. 2004. Mechanism of age-associated up-regulation in macrophage $PGE_2$ synthesis. Brain Behav. Immun. 18, 487-494   DOI   ScienceOn
32 Chou, T. Z., Fu, E. and Shen, E. C. 2003. Chitosan inhibits prostaglandin $E_2$ formation and cyclooxygenase-2 induction in lipopolysaccahride-treated RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 307, 451-458   DOI   ScienceOn
33 Jacobs, A. T. and Ignarro, L. J. 2003. Cell density-enhanced expression of inducible nitric oxide synthase in murine macrophages mediated by intereron-${\beta}$. Nitric-Oxide 8, 222-230   DOI   ScienceOn