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http://dx.doi.org/10.5352/JLS.2006.16.7.1181

Antiinflammatory Effects of New Chemical Compounds, HS-1580 Series (HS-1580, HS-1581, HS-1582)  

Kim, Ji-Young (Department of Biology, College of Natural Sciences, Pusan National University)
Kim, Kyun-Ha (Department of Biology, College of Natural Sciences, Pusan National University)
Suh, Hong-Suk (Department of Chemistry, College of Natural Sciences, Pusan National University)
Choi, Won-Chul (Department of Biology, College of Natural Sciences, Pusan National University)
Publication Information
Journal of Life Science / v.16, no.7, 2006 , pp. 1181-1187 More about this Journal
Abstract
HS-1580 series (HS-1580, HS-1581, HS-1582) can produce anti-imflammatory effects were synthesized from the marine algae extraction in 2,3,6-tribromo-4,5-dihydroxy benzyl methyl ether (TDB). Raw 264.7 cells were pre-treated with $1{\mu}g/{\mu}l$ lipopolysaccharide (LPS) and later treated with HS-1580 series. These cells of inflammatory mediators were tested as well. Nitric oxide (NO) is related to autoimmune disease and is produced by inducible NOS (iNOS). When treated with HS-1580 series, the product of NO will reduce in a dose-dependent manner. HS-1580 series significantly inhibit the iNOS protein expression. Cyclooxygenase (COX) involves with the various physiologic events and catalyzes in prostaglandin. HS-1580 series also inhibit the COX-2 protein expression as well as pro-inflammatory cytokines production such as tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})\;and\;interluekin-1{\alpha]\;(IL-1{\beta})$. These upcoming results suggest that HS-1580 series have anti-inflammatory efforts in Raw 264.7 cells by inhibiting such as iNOS, COX-2, $TNF-{\alpha}\;and\;IL-1{\beta}$ as inflammatory mediators.
Keywords
Raw 264.7; NO; COX-2, inflammation; HS-1580; HS-1581; HS-1582; $TNF-{\alpha}$;
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