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http://dx.doi.org/10.5352/JLS.2006.16.6.932

Effects of Cheonggukjang on Lipid Metabolism in Female Rats Fed Cholesterol Diet  

Lee, Choong-Un (Department of Life Science, Silla University)
Koh, Jin-Bog (Department of Life Science, Silla University)
Publication Information
Journal of Life Science / v.16, no.6, 2006 , pp. 932-937 More about this Journal
Abstract
The effects of cheonggukjang (CK) on the weight gains, serum and hepatic lipids levels were investigated in adult female rats fed the cholesterol diets. Sprague-Dawley strain rats were given four different types of diet for 4 weeks, respectively: a normal diet, a control diet (10% fat + 0.5% cholesterol), a 5% or 10% CK diets (control diet + 5% or 10% CK powder). The body weights, food intake and food efficiency ratios, and the uterine fat pad weights of 5% CK and 10% CK groups were more significantly decreased than those of the control group. The liver cholesterol and triglyceride levels were significantly lower of the 10% CK group than those of the control group. The concentrations of serum triglyceride, total cholesterol, LDL+VLDL-cholesterol, and atherogenic index ratios were significantly decreased in the 10% CK group compared with those in the control group. The HDL-cholesterol/total-cholesterol ratios was significantly increased in the 10% CK group compared with those in the control group. The fecal total lipid excretion of the 5% and 10% CK groups were more increased than those in the control group. These results showed that the 10% cheonggukjang feeding decreased the triglyceride, total cholesterol, LDL+VLDL-cholesterol and atherogenic index ratios in serum as well as the triglyceride and cholesterol in liver, and increased the HDL-cholesterol/total-cholesterol ratio in serum.
Keywords
Cheonggukjang; cholesterol; triglyceride; atherogenic index ratios; female rat;
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1 Wells, A. F, and B. H. Erschoff. 1981. Beneficial effects of pectin in prevention of hypercholesterolemia and increase in liver cholesterol in cholesterol fed rats. J. Nutr. 74, 87-93
2 Choi, Y. S. and S. Y. Lee. 1993. Cholesterol-lowering effects of soybeen products (curd or crud residue) in rats. J. Korean Soc. Food Sci. Nutr. 22, 673-677
3 Koh, J. B. 2006. Effects of Cheonggukjang on lipid metabolism in hyperlipidemic female rats. Korean J. Nutrition 39, 1-7   과학기술학회마을
4 Koh, J. B. and M. A. Choi. 2001. Effect of Cordyceps militaris on lipid metabolism in rats fed cholesterol diet. Korean J. Nutrition 34, 265-270
5 Taguchi, K., M. Kawabata, K. Ohtsuki and Y. Tanaka. 1986. Changes in dietary fiber of natto and tempeh during fermentation. J. Jpn. Soc. Nutr. Food Science 39, 203-208   DOI
6 Lee, B. Y., D. M. Kim and Kim, K. H. 1991. Physicochemical properties of viscous substance extracted from Chongkook-jang. Korean J. Food Sci. Technol. 25, 64-67
7 Koh, J. B. 2005. Effects of liquid culture of Coriolus versicolor on lipid metabolism and enzyme activities in rats fed cholesterol diet. Journal of Life Science 15, 790-795   과학기술학회마을   DOI   ScienceOn
8 Kim, B. N., J. D. Kim, S. S. Ham and S. Y. Lee. 1995. Effects of spice added Natto supplementation on the lipid metabolism in rats. J. Korean Soc. Food Nutr. 24, 121-126
9 Reeves, P. G., F. H. Nielsen and G. C. Fahey. 1993. AIN-93 purified diets for laboratory rodents final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123, 1939-1951   DOI
10 Haglund, O., R. Loustarinen, R. Wallin, I. Wibell and T. Saldeen. 1991. The effect of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin. Eur. J. Nutr. 121, 165-172   DOI
11 Yamakoshi, J., M. K. Piskula, T. Izumi, K. Tobe, M. Saito, S. Kataoka, A. Obata and M. Kikchi. 2000. Isoflavone aglycone-rich extract without soy protein attenuates atherosclerosis development in cholesterol-fed rabbits. J. Nutr. 130, 1887-1893   DOI
12 Yang, J. L., S. H. Lee and Y. S. Song. 2003. Improving effect of powders of cooked soybean and chugkukjang on blood pressure and lipid metabolism in spontaneously hypertensive rats. J. Korean Soc. Food Sci. Nutr. 32, 899-905   DOI   ScienceOn
13 Yokota, T., T. Hattori, H. Ohishi, K. Hasegawa and K. Watanabe. 1996. The effect of antioxidant-conteining fraction from fermented soybean food on atherosclerolsis development in cholesterol-fed rabbits. Lebensm-Wiss u-Technol 29, 751-755   DOI   ScienceOn
14 Mitchell, G. V., M. V. Jenkins and E. Grundell. 1989. Protein efficiency ratios and net protein ratios of selected protein foods. Plant Foods Hum. Nutr. 39, 53-58   DOI
15 Koh, J. B. and J. Y. Kim. 2004. Effects of liquid culture of Agaricus blazei Murill on lipid metabolism in rats fed cholesterol diet. Journal of Life Science 14, 531-536   DOI   ScienceOn
16 Lee, J. O., S. D. Ha, A. J. Kim, C. S. Yuh, I. S. Bang and S. H. Park. 2005. Industrial application and physiological function of Chongkukjang. Food Science Industry 38, 69-78
17 Ministry of Health and Welfare Republic of Korea. 2003. Yearbook of Health and Welfare Statistics. p. 35
18 Mol, M. A. E., R. C. Smet, A. H. M. Terpstra and C. E. West. 1982. Effect of dietary protein and cholesterol on cholesterol concentration and lipoprotein pattern in the serum of chickens. J. Nutr. 112, 1029-1025   DOI
19 Omura, K., M. Hitosugi, X. Zhu, M. Ikeda, H. Maeda, S. Tokudome. 2005. A newly derived protein from Bacillus subtilis natto with both antithrombotic and fibrinolytic effects. J pharmacological sciences, 99, 247-251   DOI   ScienceOn
20 Nagaoka, S., T. Awano and K. Hashmoto. 1997. Serum cholesterol reduction and cholesterol absorption inhobition in CaCo-2 cells by a soyprotein peptic hydrolyzate. Biosci. Biotechnol. Biochem. 61, 354-357   DOI   ScienceOn
21 Park, M. S., B. J. Kudchodkar and G. U. Liepa. 1987. Effects of dietary animal and plant proteins on the cholesterol metabolism in immature and mature rats. J. Nutr. 117, 30-35   DOI
22 Park, M. S. and G. U. Liepa. 1982. Effects of dietary protein and amino acid on the metabolism of cholesterol carring lipoproteins in rat. J. Nutr. 112, 1892-1897   DOI
23 Sumi, H., H. Hamad, H. Tsushima, H. Mihara and H. Muraki. 1987. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto : a typical and popular soybean food in the Japanese diet. Experientia 43, 1110-1111   DOI   ScienceOn
24 Suzuki, Y., K. Kondo and K. Umermura. 2003. Dietary supplementation of fermented soybean, Natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life sciences 73, 1289-1298
25 AOAC. 1980. Official Method of Analysis. pp. 211-260, 13th ed., Association of Official Analytical Chemists. Washington DC
26 Chen, J. R., S. F. Chiou and S. C. Yang. 2003. Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non dialyzed soybean protein fraction. Nutrition 19, 676-680   DOI   ScienceOn
27 Choi, Y. S. and S. Y. Lee. 1992. Review: Serum cholesterol and 3-hydroxyl 3-methyl glutaryl coenzyme A reductase. J. Korean Soc. Food Nutr. 21, 580-593
28 Folch, J., M. Lees and G. S. H. Stanley. 1957. A simple method for the isolation and purification of total lipid from animal tissues. J. Biol. Chem. 226, 497-509
29 Frings, C. S. and R. T. Dunn. 1970. A colorimetric method for determination of total serum lipid based on the sulfophospho- vanillin reaction. Am. J. Clin. Path. 53, 89-91   DOI
30 Kim, J. I., M. J. Kang and T. W. Kwon. 2003. Antidiabetic effect of soybean and chungkukjang. Korean Soybean digest 20, 44-52
31 Kim, J. S., S. M. Yoo and C. M. Chang. 1998. Physicochemical properties of traditional Chonggukjang produced in different regions. Agric. chem. Biotechnol. 41, 377-383
32 Kim, S. C., S. H. Lee and S. J. Wi. 2002 The effects of Natto mucilage on the components of serum lipid in rats. J. of Korean Oil Chemists' Soc. 19, 63-67
33 Kim, S. H., J. L. Yang and Y. S. Song. 1999. Physiologycal fuctions of Chongkukjang. Food Industry and Nutrition 4, 40-46
34 Koh, J. B. 2006. Effects of Cheonggukjang added with Phellinus linteus on lipid metabolism in hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr., 35, 410-415   과학기술학회마을   DOI   ScienceOn