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http://dx.doi.org/10.5352/JLS.2006.16.4.659

Growth-inhibitory Effects of the Plocamium telfairiae Extracts on Cancer Cells  

Kim, Ju-Young (Department of Food Science and Biotechnology, Kyungnam University)
Hwang, Ji-Hwan (Department of Food Science and Biotechnology, Kyungnam University)
Cha, Mi-Ran (Department of Food Science and Biotechnology, Kyungnam University)
Choi, Byeong-Dae (Division of Marine Bioscience, Gyeongsang National University)
Choi, Sun-Uk (Department of Food Science and Biotechnology, Kyungnam University)
Park, Hae-Ryong (Department of Food Science and Biotechnology, Kyungnam University)
Hwang, Yong-Il (Department of Food Science and Biotechnology, Kyungnam University)
Publication Information
Journal of Life Science / v.16, no.4, 2006 , pp. 659-663 More about this Journal
Abstract
The extracts of Plocamium telfairiae using several solvents with different polarities were prepared and their growth inhibitory effects were examined on the human cancer cells. We investigated the cytotoxic effects of P. telfairiae extracts on HT-29 cells by the MTT reduction assay and examining the morphological change under the inverted microscope. Among three extracts, the methanol extract showed the strongest inhibitory effect on the growth of HT-29 cells. The methanol extract was further fractionated sequentially with n-hexane, diethyl ether, ethyl acetate, and aqueous for purifying crude methanol extract. The n-hexane layer among the fractioned layers showed remarkable inhibitory activity on the growth of HT-29 cells. Moreover n-hexane layer showed the notable growth inhibition effects with a dose-dependent manner against SW620, HeLa, and MCF-7 cells as well as HT-29 cells. These results indicated that P. telfairiae extracts may be contained bioactive materials with inhibitory effect on the growth of human cancer cells.
Keywords
Plocamium telfairiae; growth inhibition; anticancer; cancer cells;
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1 Bissett, D. L., R. Chatterjee and D. P. Hannon. 1991. Chronic ultraviolet radiation -induced increase in skin iron and the photoprotective effect of topically applied iron chelators. Photochem. Photobiol. 54, 215-223   DOI   ScienceOn
2 Kim, H. S. and G. J. Kim. 1998. Effects of the feeding Hijikia fusiforme (Harvey) Okamura on lipid composition of serum in dietary hyperlipidemic rats. J. Korea Soc. Food Sci. Nutr. 27, 718-723   과학기술학회마을
3 Park, Y. J., K. H. Jeon, S. H. Kim and S. J. Bae. 2004. The effects on antimicrobial and cytotoxicity of Brassica oleracea L. fraction. J. Korea Life Science 14, 567-572   과학기술학회마을   DOI   ScienceOn
4 Min, K. J., S. H. Choung and S. J. Koo. 1999. Studies on the anticancer effect of Broussonetic kazinoki extracts. J. Korea Soc. Food Sci. 15, 231-237   과학기술학회마을
5 Ryo, T., I. S. Hiroko, H. Kaeko, H. Saburo and H. Susumu. 1998. Concurrence of agaroid and carrageenan chains in funoran from the red seaweed Gloiopeltis furcata post. et ruprecht. Carbohydrate Polymers 35, 81-87   DOI   ScienceOn
6 Bae, S. J. 2004. Anticarcinogenic effects of Sargassum fulvellum fractions on several human cancer cell lines in vitro. J. Korea Soc. Food Sci. Nutr. 33, 480-486   과학기술학회마을   DOI   ScienceOn
7 Huang, H. L. and B. G. Wang. 2004. Antioxidant capacity and lipophilic content of seaweeds collected from the qingdao coastline. J. Agric. Food Chem. 52, 4993-4997   DOI   ScienceOn
8 Lee, H. J., K. E. Park, J. S. Yoo, J. W. Ahn, B. J. Lee and Y. W. Seo. 2004. Studies on screening of seaweed extracts for peroxynitrite and DPPH radical scavenging activities. Ocean Polar Res. 26, 59-64   DOI   ScienceOn
9 Nagao, M. and T. Sugimura. 1993. Carcinogenic factors in food with relevance to colon cancer development. Mutat. Res. 290, 43-51   DOI   ScienceOn
10 Park, S. Y., B. M. Jung, Y. H. Choi and S. J. Bae. 2005. Growth inhibition effects of cancer cell lines by Gloiopeltis furacata Fractions in vitro. J. Korea Soc. Food Sci. Nutr. 34, 771-775   과학기술학회마을   DOI   ScienceOn
11 Ham, S. S., S. Y. Lee, M. Choi and H. J. Hwang Bo. 1998. Antimutagenicity and cytotoxicity effect of Woorimil wheat flour extracts added with wild herb and seaweed powder. J. Korea Soc. Food Sci. Nutr. 27, 1177-1182   과학기술학회마을
12 Kim, S. A., J. Kim, M. K. Woo, C. S. Kwak and M. S. Lee. 2005. Antimutagenic and cytotoxic effects of ethanol extracts from five kinds of seaweeds. J. Korea Soc. Food Sci. Nutr. 34, 451-459   과학기술학회마을   DOI   ScienceOn
13 Piper, J. T., S. S. Singhal, M. S. Salameh, R. T. Torman, Y. C. Awasthi and S. Awasthi. 1998. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Int. J. Biochem. Cell Biol. 30, 445-456   DOI   ScienceOn
14 Choi, H. J., S. J. Bae, N. D. Kim, J. H. Jung and Y. H. Choi. 2004. Induction of apoptosis by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp. in melanoma cells. Int. J. Mol. Med. 14, 1091-1096
15 Chung, Y. Z. 2004. Apoptotic effects of some plants on MCF-7 mammary gland adenocarcinoma cells. J. Korea Life Science 14, 61-66   DOI   ScienceOn
16 Doll, R. and R. Peto. 1981. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 66, 1192-1308   DOI
17 Fisher, B. 1984. Clinical trials for the evaluation of cancer therapy. Cancer 54, 2609-2617   DOI   ScienceOn
18 Ha, M. S., D. S. Kim, B. H. Ryu and B. H. Ji. 1986. Desmutagenic effect of extracts obtained from seaweeds. J. Kor. Fish Soc. 19, 502-508   과학기술학회마을
19 Stavric, B. 1994. Role of chemopreventers in human diet. Clin. Biochem. 27, 319-332   DOI   ScienceOn