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http://dx.doi.org/10.5352/JLS.2006.16.4.647

Antifungal Activity of Phenanthrene Derivatives from Aerial Bulbils of Dioscorea batatas Decne  

Kum, Eun-Joo (Department of Food and Nutrition, Andong National University)
Park, Sang-Jo (Experiment Station of Bioresources, Gyeongbuk Agricultural Technology Administration)
Lee, Bong-Ho (Experiment Station of Bioresources, Gyeongbuk Agricultural Technology Administration)
Kim, Jong-Sik (Department of Biological Science, Andong National University)
Son, Kun-Ho (Department of Food and Nutrition, Andong National University)
Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
Publication Information
Journal of Life Science / v.16, no.4, 2006 , pp. 647-652 More about this Journal
Abstract
Plants of the genus Dioscorea have long been used as oriental folk medicine, and Dioscorea batatas Decne has been cultivated for healthy food in Korea. Although the bulbils were produced 2,000 ton annually, there are few reports for bioactive compounds in bulbils. In this study, three phenanthrenes and two phenanthraquinones were isolated from the aerial bulbils of D. batatas Decne, and their structures were elucidated. Among them, compound 2 (6-hydroxy-2,7-dimethoxy-1,4-phenanthraquinone) has not been reported previously. Evaluation of antimicrobial activities based on disk-diffusion assay, MIC and MFC showed the compound 12 (6,7-dihydroxy-2,4-dimethoxyphenanthrene) has strong antimicrobial activity with $25\;{\mu}g/ml$ of MIC and MFC against Candida albicans. Our results suggested that compound 12 has a potent antifungal activity, and the antimicrobial activity and its spectrum are modulated by hydroxylation and methoxylation of phenanthrene ring moiety of the compound.
Keywords
6,7-Dihydroxy-2,4-dimethoxyphenanthrene; antifungal activity; Dioscorea batatas Decne; fungicidal activity;
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