Induction of G2/M Arrest of the Cell Cycle by Genistein in Human Bladder Carcinoma and Leukemic Cells
![]() |
Kim, Eu-Kyum
(Korea Science Academy)
Myong, You-Ho (Korea Science Academy) Song, Kwan-Sung (Korea Science Academy) Lee, Ki-Hong (Korea Science Academy) Rhu, Chung-Ho (Division of Applied Life Science, Gyeongsang National University) Choi, Yung-Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control, Dongeui University Graduate School) |
1 | Guadagno, T.M., M. Ohtsubo, J.M. Roberts and R.K. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572-1575 DOI |
2 |
Shao, Z.-M., M.L. Alpaugh, J.A. Fontana and S.H. Barsky. 1998. Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by |
3 | Bektic, J., R. Guggenberger, I.E. Eder, A.E. Pelzer, A.P. Berger, G. Bartsch and H. Klocker. 2005. Molecular effects of the isoflavonoid genistein in prostate cancer. Clin. Prostate Cancer 4, 124-129 DOI ScienceOn |
4 |
Datto, M.B., Y. Yu and X.-F. Wang. 1995. Functional analysis of the transforming growth factor |
5 | Mueller, S.C., Y. Yeh and W.T. Chen. 1992. Tyrosine phosphorylation of membrane proteins mediates cellular invasion by transformed cells. J. Cell Biol. 119, 1309-1325 DOI ScienceOn |
6 | Xiong, Y., G. Hannon, H. Zhang, D. Casso, R. Kobayashi and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366,701-704 DOI ScienceOn |
7 | Zhang, W., L. Grasso, C.D. McClain, A.M. Gambel, Y. Cha, S. Travali, A.B. Deisseroth and W.E. Mercer. 1995. p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/marcrophage differentiation. Cancer Res. 55, 668-674 |
8 | Zi, X., D.K. Feyes and R. Agarwal. 1998. Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast canecr cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinase and associated cyclins. Clinical Cancer Res. 4, 1055-1064 |
9 | Traganos, F., B. Ardelt, N. Halko, S. Bruno and Z. Darzynkiewicz. 1992. Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res. 52, 6200-6208 |
10 | Mezencev, R., J. Mojzis, M. Pilatova and P. Kutschy. 2003. Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. Neoplasma 50, 239-245 |
11 | Ohtsubo, M. and J.M. Roberts. 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259,1908-1912 DOI |
12 | Ravindranath, M.H., S. Muthugounder, N. Presser and S. Viswanathan. 2004. Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 546, 121-165 DOI |
13 | Sarkar, F.H. and Y. Li. 2002. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 21, 265-280 DOI ScienceOn |
14 | Spinozzi, F., C. Pagliacci, M. Graziella, M. Rasalba, F. Grignani, C. Riccardi and I. Nicoletti. 1994. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in jurkat T-leukemia cells. Leuk. Res. 18, 431-439 DOI ScienceOn |
15 |
Tchou, W.-W., W.N. Rom and K.-M. Tchou-Wong. 1996. Novel form of |
16 | Morgan, D.O. 1995. Principles of CDK regulation. Nature 374, 131-134 DOI ScienceOn |
17 | Ohsumi, K., C. Katagiri and T. Kishimoto. 1993. Chromosome condensation in Xenopus mitotic extracts without histone H1. Science 262, 2033-2035 DOI |
18 | Santibanez, J.F., A. Navapro and J. Martinez. 1997. Genistein inhibits proliferation and in vitro invasive potential of human prostate cancer cell lines. Anticancer Res. 17,1199-1204 |
19 | Li, Y., C.W. Jenkins, M.A. Nichols and Y. Xiong. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent kinase p21. Oncogene 9, 2261-2268 |
20 | Steele, V.E., M.A. Pereira, C.C. Sigman and G.J. Kelloff. 1995. Cancer chemoprevention agent development strategies for genistein. J. Nutri. 125, 713S-716S |
21 | Waga, S., G.J. Hannon, D. Beach and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369, 574-578 DOI ScienceOn |
22 | Fattaey, A. and R.N. Booher. 1997. Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. Prog. Cell Cycle Res. 3, 233-240 |
23 | Fotsis, T., M. Pepper, H. Adlercreutz, G. Fleishmann, T. Hase, R. Montesano and L. Schweigerer. 1993. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl. Acad. Sci. USA 90, 2690-2694 |
24 | Jiang, H., J. Lin, Z.Z. Su, F.R. Collart, E. Huberman and P.B. Fisher. 1994. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF/CIP1, expression in the absence of p53. Oncogene 9, 3397-3406 |
25 | Koff, A., A. Giordano, D. Desai, K. Yamashita, J.W. Harper, S. Elledge, T. Nishimoto, D.O. Morgan, B.R. Franza and J.M. Roberts. 1992. Formation and activation of a cyclin E-Cdk2 complex during the G1 phase of the human cell cycle. Science 257, 1689-1694 DOI |
26 |
Krek, W. and E.A. Nigg. 1991. Differential phosphorylation of vertebrate |
27 | Markovits, J., C. Linassier, P.H. Fosse, J. Couprie, A. Jacquemin-Cablon, J.M. Saucier, J.B. Le Pecq and A. Larsen. 1989. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase. Cancer Res. 49, 5111-5117 |
28 | Meyerson, M. and E. Harlow. 1994. Identification of G1 kinase activity for Cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14, 2077-2086 DOI |
29 | Matsushime, H., D.E. Quelle, S.A. Shurtleff, M. Shibuya, C.J. Sherr and J.Y. Kato. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14, 2066-2076 DOI |
30 | Messina, M.J., V. Persky, K.D. Setchell and S. Barnes. 1994. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer 21, 113-131 DOI ScienceOn |
31 | Belenguer, P., L. Pelloquin, V. Baldin, M.L. Oustrin and B. Ducommun. 1995. The fission yeast Nim1/Cdr1 kinase: a link between nutritional state and cell cycle control. Prog. Cell Cycle Res. 1, 207-214 |
32 | Biggs, J.R., J.E. Kudlow and A.S. Kraft. 1995. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. J. Biol. Chem. 271, 901-906 DOI |
33 | Choi, Y.H., W.H. Lee, K.Y. Park and L. Zhang. 2000. p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn. J. Cancer Res. 91, 164-173 DOI |
34 | Choi, Y.H., L. Zhang, W.H. Lee and K.Y. Park. 1998. Genistein-induced G2/M arrest is associated with the inhibition of cyclin B1 and the induction of p21 in human breast carcinoma cells. Int. J. Oncol. 13, 391-396 |
35 | Constantinou, A., K. Kiguchi and E. Huberman. 1990. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein. Cancer Res. 50, 2618-2624 |
36 | Cooper, M.J., J.J. Haluschak, D. Johnson, S. Schwartz, L.J. Morrison, M. Lippa, G. Hatzivassiliou and J. Tan. 1994. p53 mutations in bladder carcinoma cell lines. Oncol. Res. 6, 569-579 |
37 | Elledge, S.J. and J.W. Harper. 1994. Cdk inhibitors: on the threshold of checkpoints and development. Curr. Opin. Cell Biol. 6, 847-852 DOI ScienceOn |
38 | Rauth, S., J. Kichina and A. Green. 1997. Inhibition of growth and induction of differentiation of metastatic melanoma cells in vitro by genistein: chemosensitivity is regulated by cellular p53. Bri. J. Cancer 75, 1559-1566 DOI ScienceOn |
39 | Dorai, T. and B.B. Aggarwal. 2004. Role of chemopreventive agents in cancer therapy. Cancer Lett. 215, 129-140 DOI ScienceOn |
40 |
Dulic, V., G.H. Stein, D.F. Far and S.I. Reed. 1998. Nuclear accumulation of |
41 | Sanchez, V., A.K. McElroy and D.H. Spector. 2003. Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus. J. Virol. 77, 13214-13224 DOI |
42 | Kumagai, A. and W.G. Dunphy. 1991. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64, 903-914 DOI ScienceOn |
43 | Akiyama, T., J. Ishida, S. Nakagawa, H. Ogawara, S. Watanabe, N. Itoh, M. Shibuya and Y. Fukami. 1987. Genistein, a specific inhibitor of tyrosine-specific protein kinase. J. Biol. Chem. 262, 5592-5595 |
44 | Girard, F., U. Strausfeld, A. Fernandez and N.J.C. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibloblasts. Cell 67, 1169-1179 DOI ScienceOn |
![]() |