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http://dx.doi.org/10.5352/JLS.2006.16.3.442

Inhibition of Matrix Metalloproteinase-2 Activity of Flavonol Glycosides from Cedreia sinensis  

Hwang Seon-Woo (Division of Applied Life Science, Institute of Agriculture & Life Sciences, Gyeongsang National University)
Ha Tae-Joung (Yeongnam Agricultural Research Institute, National Institute of Crop Science (RDA))
Kho Yung-Hee (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Chun Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Lee Jun (Division of Applied Life Science, Institute of Agriculture & Life Sciences, Gyeongsang National University)
Kwon Hyun-Sook (Division of Applied Life Science, Institute of Agriculture & Life Sciences, Gyeongsang National University)
Park Ki-Hun (Division of Applied Life Science, Institute of Agriculture & Life Sciences, Gyeongsang National University)
Yang Min-Suk (Division of Applied Life Science, Institute of Agriculture & Life Sciences, Gyeongsang National University)
Publication Information
Journal of Life Science / v.16, no.3, 2006 , pp. 442-446 More about this Journal
Abstract
Cedrela sinensis is a broadleaf tree that is widely cultivated in Korea and China. It was used for treating enteritis, dysentery, and skin itch in oriental medicine. In this study, three major flavonoids, kaempferol-3-O-rhamnoside (1), quercetin-3-O-rhamnoside (2), and quercetin-3-O-glucoside (3), were isolated from the leaf of Cedrela sinensis. The biological activities of these compounds were tested by inhibitory activity of matrix metalloproteinases-2 (Type IV collagenase) method together with a cytotoxicity and a apoptosis test against human cancer cell lines.
Keywords
Cedrela sinensis; flavonol glycosides; cytotoxic activity; apoptosis; matrix metalloproteinases-2;
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