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http://dx.doi.org/10.5352/JLS.2006.16.2.310

Antifungal Activity of Fistulosides, Steroidal Saponins, from Allium fistulosum L  

Sohn Ho-Yong (Department of Food and Nutrition, Andong National University)
Kum Eun-Joo (Department of Food and Nutrition, Andong National University)
Ryu Hee-Young (Department of Food and Nutrition, Andong National University)
Jeon Su-Jin (Department of Food and Nutrition, Andong National University)
Kim Nam-Soon (Genome Research Center, Korea Research Institute of Bioscience and Biotechnology)
Son Kun-Ho (Department of Food and Nutrition, Andong National University)
Publication Information
Journal of Life Science / v.16, no.2, 2006 , pp. 310-314 More about this Journal
Abstract
Allium fistulosum L. (Welsh onion) is a perennial herb that is widely cultivated throughout the world, especially in China, Japan and Korea. Although, various activities were reported, little is known about antimicrobial activity of A. fistulosum L.. In this study, strong antimicrobial substances, fistuloside A, B, and C were isolated from the edible parts of A. fistulosum L. and their antimicrobial activity was evaluated with pathogenic- or food-spoilage microorganism based on disk-diffusion assay, minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) determination. Fistuloside A and fistuloside C showed strong antifungal activity and anti-Proteus activity, while fistuloside B is effective to only fungi. The fistuloside C showed a prominent antifungal activity with $3.1{\sim}6.2{\mu}g/ml$ of MIC and MFC. Our results indicated that fistuloside C has a prominent antifungal activity and support the use of A. fistulosum to treat microbial infection.
Keywords
Allium fistulosum L.; antifungal activity; fistuloside; fungicidal activity; steroidal saponins;
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