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http://dx.doi.org/10.5352/JLS.2005.15.6.968

Investigation of Porcine Melanocortin-4 Receptor (MC4R) Polymorphism on Economic Traits  

Kim Kwan-Suk (Department of Animal Science, Chungbuk National University)
Shin Hee Young (Department of Animal Science, Chungbuk National University)
Lee Joong-Jae (Department of Animal Science, Chungbuk National University)
Hong Sung-Kwang (Performance Testing Station, Korea Swine Association)
Choi Bong-Hwan (Animal genomics and Bioinformatics Division, National Livestock Research Institute)
Kim Tae-Hun (Animal genomics and Bioinformatics Division, National Livestock Research Institute)
Lee Hak-Kyo (Genetic Information Research Center, Hankyung University)
Cho Byung-Wook (Department of Animal Science, Miryang National University)
Publication Information
Journal of Life Science / v.15, no.6, 2005 , pp. 968-971 More about this Journal
Abstract
The Melanocortin-4 receptor gene (MC4R) regulates the energy balance and the genetic basis of obesity. A polymorphism in the porcine melanocortin-4 receptor has previously shown to be associated with growth, fat deposition and feed intake. In this study, the polymorphism of the gene was studied in several pig breeds of Duroc, Landrace, Berkshire, and Yorkshire. The results showed that the frequencies of MC4R genotype varied among those breeds. Association analyses were also performed between the MC4R polymorphism and average daily gain, feed conversion ratio, backfat thickness and lean percentage phenotypes. The results strongly support that the MC4R polymorphism can be used DNA marker selection indicator for economically important traits for pig breeding program in Korea.
Keywords
Economic traits; pig; PCR-RFLP; Polymorphism; MC4R;
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