Biological Effect of Metronidazole Resistance in Helicobacter Pylori |
Lee Gin Hyug
(Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, Univeristy of Ulsan College of Medicine)
Lee Sun-Mi (Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine) Nam Won-Hee (Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine) Kim Eun Sil (Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine) Kim Jin Ho (Division of Gastroenterology, Department of Internal Medicine, Asan Medical Center, Univeristy of Ulsan College of Medicine) Kang Ho Young (Department of Microbiology, Pusan National University) Jeong Jin-Yong (Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine) |
1 | Seyler, R. W., J. W. Olson and R. J. Maier. 2001. Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization. Infect Immun. 69(6):4034-40 DOI ScienceOn |
2 | Jeong, J. Y., A. K. Mukhopadhyay, J, K. Akada, D. Dailidiene, P. S. Hoffman and D. E. Berg. 2001. Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole. J. Bact. 183:5155-5162 DOI ScienceOn |
3 | Raudonikiene. A, N. Zakharova, W. W. Su, J. Y. Jeong, L. Bryden, P. S. Hoffman, D. E. Berg, and K. Severinov. 1999. Helicobacter pyloriwith separate beta- and beta'-subunits of RNA polymerase is viable and can colonize conventional mice. Mol. Microbiol. 32:131-13 DOI ScienceOn |
4 | Tomb, J. F., O. White, A R. Kerlavage, R. A. Clayton, G. G. Sutton, R. D. Fleischmann, K. Ketchum, H. Klenk, S. Gill, B. Dougherty, K. Nelson, J. Quackenbush, L. Zhou, E. Kirkness, S. Peterson, B. Loftus, D. Richardson, R. Dodson, H. Khalak, A Glodek, K. McKenney, L. Fitzegerald, N. Lee,M. Adams, E. Hickey, D. Berg, J. Gocayne, T. Utterback, J. Peterson, J. Kelley, M. Cotton, J. Weidman, C. Fujii, C. Bowman, L. Watthey, E. Wallin, W. Hayes, M. Borodovsky, P. Karp, H. Smith, C. Fraser, and J. Venter. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 388:539-547 Ā 堽ㆮ 倀 훿씊匿Ȁ 烔⨀ 考憺Ȁ憺Ȁ ̀ 샓⨀ 烔⨀ ᄃ 돀ᢴ⨀ 塨?⨀ ⃚⨀ 돐 ꡖ잖 DOI ScienceOn |
5 | Mukhopadhyay A. K, J. Y. Jeong, D. Dailidiene, P. S. Hoffman and D. E. Berg. 2003. The fdxA ferredoxin gene can down-regulate frxA nitroreductase gene expression and is essential in many strains of Helicobacter pylori. J Bacteriol. 185(9):2927-2935 DOI ScienceOn |
6 | Jeong, J. Y., A. K. Mukhopadhyay, D. Dailidiene, Y. Wang, B. Velapatio. R. H. Gilman, A. J. Parkinson, G. B Nair, B. C. Y. Wong, S. K. Lam, R. Mistry, I. Segal, Y. Yuan, H. Gao, T. Alarcon, M. L. Brea, Y. Ito, D. Kersulyte, H.-K. Lee, Y. Gong, A. Goodwin, P. S. Hoffman, and D. E. Berg. 2000. Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes cause moderate and highlevel metronidazole resistance in Helicobacter pylori. J. Bacteriol. 182:5082-5090 DOI ScienceOn |
7 | Kersulyte, D., A. K. Mukhopadhyay, B. Velapati-o, W. W. Su, Z. J. Pan, C. Garcia, V. Hernandez, Y. Valdez, R. S. Mistry, R. H. Gilman, Y. Yuan, H. Gao, T. Alarcon, M. Lopez Brea, G. B. Nair, A. Chowdhury, S. Datta, M. Shirai, T. Nakazawa, R. Ally, I. Segal, B. C.Y. Wong, S. K. Lam, F. Olfat, T. Boren, L. Engstrand, O. Torres, R. Schneider, J. E. Thomas, S. Czinn, and D. E. Berg. 2000. Differences in Genotypes of Helicobacter pylori from Different Human Populations. J. Bacteriol. 182:3210-3218 DOI ScienceOn |
8 | Megraud, F., N. Lehn, T. Lind, E. Bayerdorffer, C. O'Morain, R. Spiller, P. Unge, S. Y. van Zanten, M. Wrangstadh, and C. F. Burman. 1999. Antimicrobial susceptibility testing of Helicobacter pyloriin a large multicenter trial: the MACH 2 study. Antimicrob. Agents Chemother. 43:2747-275 |
9 | Miyaji, H., T. Azuma, S. Ito, H. Suto, Y. Ito, Y. Yamazaki, F. Sato, M. Hirai, M. Kuriyama, T. Kato and Y. Kohli. 1997. Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan. Aliment. Pharmacal. Ther. 11:1131-1136 DOI ScienceOn |
10 | Mukhopadhyay, A K., D. Kersulyte, J. Y. Jeong, S. Datta, Y. Ito, A Chowdhury, S. Chowdhury, A Santra, S. K. Bhattacharya, T. Azuma, G. B. Nair, and D. E.Berg. 2000. Distinctiveness of genotypes of Helicobacter pylori in Calcutta India. J. Bacteriol. 182:3219-3227 DOI ScienceOn |
11 | Andersson, D. I. and B. R. Levin. 1999. The biological cost of antibiotic resistance. Curr Opin Microbiol. 2(5):489-93 DOI ScienceOn |
12 | Bjorkman, J. and D. I. Andersson. 2000. The cost of antibiotic resistance from a bacterial perspective. Drug Resist Updat. 3(4):237-245 DOI ScienceOn |
13 | Goodwin, A., D. Kersulyte, G. Sisson, S. J. O. Veldhuyzen van Zanten, D. E. Berg, and P. S. Hoffman. 1998. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Mol. Microbiol. 28:383-393 DOI ScienceOn |
14 | Bjorkman, J., D. Hughes. and D. I. Andersson. 1998. Virulence of antibiotic-resistant Salmonella typhimurium. Proc Natl Acad Sci USA. 95(7):3949-53 |
15 | Bjorkman, J., I. Nagaev, O. G. Berg, D. Hughes and D. I. Andersson. 2000. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science. 2000 287(5457):1479-82 DOI ScienceOn |
16 | Glupczynski, Y. 1998. Antimicrobial resistance in Helicobacter pylori: a global overview. Acta. Gastroenterol. Belg. 61:35736 |
17 | Ching, C. K., K. P. Leung, R. W. H. Yung, S. K. Lam, B. C. Y. Wong, K. C. La, and C. L. Lai. 1996. Prevalence os metronidazole resistant Helicobacter pylori strains among Chinase peptic ulcer disease patients and normal controls in Hong Kong. Gut 38:675-67 DOI ScienceOn |