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http://dx.doi.org/10.5352/JLS.2005.15.6.1028

The Effect of Capsosiphon fulvecense extract on Inhibition of Platelet Aggregation and Serum Lipid Level in Ovariertomized Rats  

Park Mi-Hwa (Dept. of Food Science and Nutrition, Silla University)
kim Mihyang (Dept. of Food Science and Nutrition, Silla University)
Publication Information
Journal of Life Science / v.15, no.6, 2005 , pp. 1028-1033 More about this Journal
Abstract
Estrogen deficiency in peri-and postmenopausal women results in variety of neurovegetative, psychic and somatic symptoms, and may contribute to severe diseases within the aged female population. Capsosiphon fulvecense (CF), green algae, loaded with large amount of proteins, calcium and ion. This seaweed is distributed in the Southern coast in Korea and widely throughout the world. Our objective was to investigate the effects of Capsosiphon fulvecense (CF) extract on serum lipid concentration and platelet aggregation in ovariectomized rats. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-Control), ovariectomized rats supplemented with CF at 50mg/kg bw/d (OVX-CF5O) and ovariectomized rats supplemented with CF at 200mg/kg bw/d (OVX-CF200). The serum triglyceride level was significantly decreased after supplemented with the CF extracts. The serum HDL-cholesterol level in the OVX-CF group was significantly higher than the level in the OVX-control group. The ability of platelet aggregation treated with CF extract (CF group) was $7\%$ less than OVX-control group. Taken these together, CF extract may be used to improve the quality of life in menopausal women.
Keywords
Capsosiphon fulvecense; ovariectomized rats; platelet aggregation; serum lipids;
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