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http://dx.doi.org/10.5352/JLS.2005.15.4.595

Inhibitory Effect of Radish on Gastric Cell Toxicity and Interleukin-8 Production Induced by Helicobacter pylori  

Shon Yun Hee (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University)
Suh Jeong Ill (Department of Internal Medicine, College of Medicine Dongguk University)
Park In Kyung (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University)
Hwang Cher Won (Department of Enviromental Microbiology, Handong University)
Kim Cheorl Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine Dongguk University)
Nam Kyung Soo (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University)
Publication Information
Journal of Life Science / v.15, no.4, 2005 , pp. 595-599 More about this Journal
Abstract
The efforts of Korean and Japanese radishes on the viability and interleukin (JL)-8 production by Helicobacter pylori were investigated in human gastric epithelial cell. Cell viability was significantly decreased when they were incubated with H. pylori toxin (p <0.05, p<0.01 and p<0.005). Co-incubation with Korean or Japanese radish increased H. pylori toxin-inhibited cell growth in a concentration-dependent manner. The production of IL-8 was greatly increased in H. pylori-infected gastric epithelial cell in concentration- and time-dependent manners. The increased production of IL-8 was significantly inhibited by Korean (p<0.05 and p<0.01) or Japanese (p<0.05) radishes $(5\~10mg/ml)$. These results indicate that Korean and Japanese radishes have protective effects on H. pylori-inhibited cell growth and H. pylori-induced gastric mucosal cell inflammation by suppressing the production of inflammatory cytokine (IL-8) from gastric epithelial cell.
Keywords
Radish; Helicobacter pylori; gastric epithelial cell; IL-8;
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