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http://dx.doi.org/10.5352/JLS.2005.15.4.572

The Hepatoprotective Effects of Epimedii Herba through the Antioxidation  

Ha Bae Jin (Department of Bioscience and Biotechnology, Silla University)
Kim Hee Jin (Department of Bioscience and Biotechnology, Silla University)
Lee Sang Hun (Department of Bioscience and Biotechnology, Silla University)
Ha Jong-Myung (Department of Bioscience and Biotechnology, Silla University)
Lee Sang-Hyeon (Department of Bioscience and Biotechnology, Silla University)
Lee Jae-Hwa (Department of Bioscience and Biotechnology, Silla University)
Lee Dong-Geun (Department of Bioscience and Biotechnology, Silla University)
Park Eun Kyung (Department of Bioscience and Biotechnology, Silla University)
Nam Chun Suk (Department of Bioscience and Biotechnology, Silla University)
Publication Information
Journal of Life Science / v.15, no.4, 2005 , pp. 572-577 More about this Journal
Abstract
In this study, the effect of Epimedii Herba (EH) on the antioxidative enzymatic activity was investigated. EH (100mg/kg) was intraperitoneally administered into rats for 2 weeks. On the last day, carbon tetrachloride $(50\%\;CCl_4,\;3.3ml/kg,\;i.p.)$ dissolved in olive oil was injected before 12 hours. EH-pread-ministered and $CCl_4-treated$ (EC) group showed higher inhibitory effect in aminotransferase (AST, ALT) activity compared to $CCl_4-treated (CT)$ group. Superoxide dismutase (SOD) and Catalase in EC group were increased compared to those of CT group. The activity of glutathione peroxidase (GPx) was significantly higher than those of CT group compared to EC group. These results suggest that EH has a hepatoprotective effect through scavenging the free radicals induced by $CCl_4$.
Keywords
Epimedii Herba; Hepatotoxicity; Antioxidative enzyme; Histopathology;
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