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http://dx.doi.org/10.5352/JLS.2005.15.2.267

The Application of Nanoliposome Composed of Ceramide as an Anti-irritant in Cosmetics  

Jo Byoung Kee (R&D center, Coreana Cosmetics Co., Ltd.)
Ahn Gi Woong (R&D center, Coreana Cosmetics Co., Ltd.)
Shin Bong Soo (R&D center, Coreana Cosmetics Co., Ltd.)
Jeong Ji Hean (R&D center, Coreana Cosmetics Co., Ltd.)
Park Hae-Ryong (Division of Food Science and Biotechnology, Kyungnam University)
Hwang Yong-Il (Division of Food Science and Biotechnology, Kyungnam University)
Publication Information
Journal of Life Science / v.15, no.2, 2005 , pp. 267-272 More about this Journal
Abstract
The objective of this study is to suggest the potentialities of nanoliposome composed of ceramide as an anti-irritant against various irritants used in cosmetics. Ceramides are major structural components of the epidermal permeability barrier, which is known to play an essential part in human physiology by not only preventing the loss of water from the body but also protecting the body from external physical, chemical, and microbial insults. According to the results, better effects on reinforcement of skin barrier function and anti-irritation were obtained with nanoliposome composed of ceramide than with dispersed ceramide. And, we performed in vitro skin penetration test using horizontal Franz diffusion cells with skin membrane prepared from hairless mouse to evaluate the influence of nanoliposome composed of ceramide on the skin penetration of lactic acid in formulations. From the results, we found that the anti-irritation effects of nanoliposome containing ceramide were due to reduced penetration rate of irritants. Conclusively, we could develop a new anti-irritation system and apply this nanoliposome composed of ceramide to the final cosmetic products successfully.
Keywords
nanoliposome; ceramide; anti-irritation; skin barrier functon;
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