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http://dx.doi.org/10.5352/JLS.2005.15.2.197

Effect of chiro-inositol from Soybean on Reducing Hyperglycemia and Its Role for Nutraceutic Supplement for Insulin Resistance  

Hong Yonggeun (Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University)
Pak Yunbae (Department of Biochemistry, Division of Life Science, College of Natural Sciences, Graduate School of Applied Life Science, Gyeongsang National University)
Publication Information
Journal of Life Science / v.15, no.2, 2005 , pp. 197-201 More about this Journal
Abstract
Studies with diabetic mammalian systems showed that chiro-inositol administration decreased blood glucose levels. We investigated which foodstuffs contain large amounts of chiro-inositol by surveying vegetables, edible plants and other staples in an effort to explore the nutritional or therapeutic supplements of chiro-inositol for diabetic patients. In the course of our investigation, we found that soybean and soybean derivatives have high chiro-inositol levels (upto 20 mg/g). The purified chiro-inositol from the soybean was then tested for reducing hyperglycemia by administrating the chiro-inositol in streptozotocin-treated diabetic rats. The results showed that the intragastric administration of 50 mg chiro-inositol/kg BW lowered hyperglycemia by $40\%$ and that the effect was sustained for approximately 12 hr.
Keywords
Insulin resistance; chiro-inositol; soybean; diabetes; blood glucose level;
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