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http://dx.doi.org/10.5352/JLS.2005.15.1.001

Subacute Inhalation Toxicity Study of Dimethyl Disulfide in F344 Rats  

Kim Hyeon-Yeong (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
Lee Sung-Bae (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
Han Jung-Hee (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
Chung Yong-Hyun (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
Kim Hyoung-Chin (Korea Research Institute of Bioscience and Biotechnology)
Shin Jin-Young (College of Veterinary Medicine, Chonnam National University)
Shin Dong-Ho (College of Veterinary Medicine, Chonnam National University)
Kim Jong-Choon (College of Veterinary Medicine, Chonnam National University)
Lee Young-Mook (Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation)
Publication Information
Journal of Life Science / v.15, no.1, 2005 , pp. 1-8 More about this Journal
Abstract
The purpose of this study was to investigate the potential subacute toxicity of dimethyl disulfide by 3 weeks inhalation in F344 rats. The test article, dimethyl disulfide was exposed by inhalation to male and female rats at dose levels of 0, 5, 25, or 125 ppm/6 hrs/ day for 3 weeks. Five rats/ sex/ group were sacrificed on day 4 after the initiation of treatment, while 5 rats/ sex/ group were sacrificed at the end of treatment period. During the test period, clinical signs, mortality, body weights, food consumption, hematology, serum biochemistry, and gross findings were examined. Slight decreases in body weight gain were noted in both sexes of the highest dose group in a dose dependent manner but were only statistically different from the control animals in males of the group. A slight non-significant reduction in food consumption were also noted in the both sexes of the highest dose group. There were no adverse effects on mortality, clinical signs, hematology, serum biochemistry, and necropsy findings at any dose tested. Based on these results, it was concluded that the 3 weeks repeated dose of dimethyl disulfide by inhalation resulted in suppressed body weight gain and decreased food consumption at 125 ppm of both sexes. In the present experimental conditions, the target organ was not determined in rats. The no­observed-adverse-effect level (NOAEL) was considered to be 25 ppm/6 hrs/day for both sexes.
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