PGE2 Mediated INF-γ Gene Methylation Through cAMP Signaling Pathway in Human Jurkat T Cells
![]() |
Jeon, Byung-Hun
(College of Oriental Medicine, Wonkwang University)
Ju, Sung-Min (College of Oriental Medicine, Wonkwang University) Jeong, Jae-Sung (College of Oriental Medicine, Wonkwang University) Kim, Myung-Wan (College of Oriental Medicine, Wonkwang University) Yun, Young-Gab (College of Oriental Medicine, Wonkwang University) Park, Hyun (School of Medicine & Medical Resources Research Center, Wonkwang University) Chung Hun-taeg (School of Medicine & Medical Resources Research Center, Wonkwang University) Han, Dong-Min (College of Natural Sciences and Institute of Basic Natural Sciences, Wonkwang University) Kim, Won-Sin (College of Natural Sciences and Institute of Basic Natural Sciences, Wonkwang University) |
1 | Benbernou, N., S. Esnault, H. C. Shin, H. Fekkar and M. Guenounou. 1997. Differential regulation of IFN-gamma, IL-10 and inducible nitric oxide synthase in human T cells by cyclic AMP-dependent signal transduction pathway. Immunology 91, 361-368 DOI ScienceOn |
2 |
Mikovits, J. A., H. A. Young, P. Vertino, J-P. Issa, P. M. Pitha, S. Turcoski-Corrales, D. D. Taub, C. L. Petrow, S. B. Baylin and F. W. Ruscetti. 1998. Infection with Human Immunodeficiency Virus Type 1Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN- |
3 | Munoz, E., A. M. Zubiaga, M. Merrow, N. P. Sauter and B. T. Huber. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172, 95-103 DOI ScienceOn |
4 | Penix, L., W. M. Weaver, Y. Pang, H. A. Young and C. B. Wilson. 1993. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J. Exp. Med. 178, 1483-1496 DOI ScienceOn |
5 | Snijdewint, F. G., P. Kalinski, E. A. Wierenga, J. D. Bos and M. L. Kapsenberg. 1993. Prostaglandin E_2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150, 5321-5329 |
6 | Schmidt, H. H. and U. Walter. 1994. NO at work. Cell. 78, 919-925 DOI ScienceOn |
7 | Taylor-Robinson, A. W., F. Y. Liew, A. Severn, D. Xu, S. J. McSorley, P. Garside, J. Padron and R. S. Phillips. 1994. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur. J. Immunol. 24, 980-984 DOI ScienceOn |
8 |
Young, H. A., P. Ghosh, J. Ye, J. Lederer, A. Lichtman, J. Gerard, L. Penix, C. B. Wilson, A. J. Melvin, M. E. McGurn, D. B. Lewis and lvin, M. E. 1994. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN- |
9 | Young, H. A. 1996. Regulation of interferon-gamma gene expression. J. Interferon. Cytokine. Res. 16, 563-568 DOI ScienceOn |
10 |
Katamura, K., N. Shintaku, Y. Yamauchi, T. Fukui, Y. Ohshima, M. Mayumi and K. Furusho. 1995. Prostaglandin |
11 | Liew, F. Y. 1995. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7, 396-399 DOI ScienceOn |
12 | Laird, P. W. and R. Jaenisch. 1994. DNA methylation and cancer. Hum. Mol. Genet. 3, 1487-1495 |
13 | Lee, H. J., N. Koyano-Nakagawa, Y. Naito, J. Nishida, N. Arai, K. Arai and T. Yokota. 1993. cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J. Immunol. 151, 6135-6142 |
14 | Leonhardt, H. and T. H. Bestor. 1993. Structure, function and regulation of mammalian DNA methyltransferase. In DNA methylation: molecular biology and biological significance (Jost JP, Saluz HP, eds), 109-119, Birkhauser Verlag, Basel, Switzerland |
15 | Mary, D., C. Aussel, B. Ferrua and M. Fehlmann. 1987. Regulation of interleukin 2 synthesis by cAMP in human T cells. J. Immunol. 139, 1179-1184 |
16 | Melvin, A. J., M. E. McGurn, S. J. Bort, C. Gibson and D. B. Lewis. 1995. Hypomethylation of the interferon-gamma gene correlates with its expression by primary T-lineage cells. Eur. J.Immunol. 25, 426-430 DOI ScienceOn |
17 | Jones, P. A. 1996. DNA methylation errors and cancer. Cancer. Res. 56, 2463-2467 |
18 |
Katamura, K., T. Fukui, T. Kiyomasu, J. Iio, G. Tai, H. Ueno, T. Heike, M. Mayumi and K. Furusho. 1998. IL-4 and prostaglandin |
19 | Betz, M. and B. S. Fox. 1991. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146, 108-113 |
20 | Chang, R. H., M. H. Feng, W. H. Liu and M. Z. Lai. 1997. Nitric oxide increased interleukin-4 expression in T lymphocytes. Immunology 90, 364-369 DOI ScienceOn |
21 | Chrivia, J. C., T. Wedrychowicz, H. A. Young and K. J. Hardy. 1990. A model of human cytokine regulation based on transfection of interferon gamma gene fragments directly into isolated peripheral blood T lymphocytes. J. Exp. Med. 172, 661-664 DOI ScienceOn |
22 | Gajewski, T. F., S. R. Schell and F. W. Fitch. 1990. Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones. J. Immunol. 144, 4110-4120 |
23 | Gray, J.G., G. Chandra, W. C. Clay, S. W. Stinnett, S. A. Haneline, J. J. Lorenz, I. R. Patel, G. B. Wisely, P. J. Furdon and J. D. Taylor. 1993. A CRE/ATF-like site in the upstream regulatory sequence of the human interleukin 1 beta gene is necessary for induction in U937 and THP-1 monocytic cell lines. Mol. Cell. Biol. 13, 6678-6689 |
24 | Hmadcha, A., F. J. Bedoya, F. Sobrino and E. Pintado. 1999. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J. Exp. Med. 190, 1595-1604 DOI |
25 | Issa, J. P., P. M. Vertino, J. Wu, S. Sazawal, P. Celano, B. D. Nelkin, S. R. Hamilton and S. B. Baylin. 1993. Increased cytosine DNA-methyltransferase activity during colon cancer progression. J. Natl. Cancer. Inst. 85, 1235-1240 DOI |
26 | Johnson, G. S., R. M. Friedman and I. Pastan. 1971. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3': 5'-cyclic monphosphate and its derivatives. Proc. Natl. Acad. Sci. USA. 68, 425-429 DOI ScienceOn |
27 | Becker, P. B., S. Ruppert, and G. Schutz. 1987. Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell 51, 435-443 DOI ScienceOn |
![]() |