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http://dx.doi.org/10.5352/JLS.2004.14.4.541

Effort of Capsaicin on the Lipid Peroxidation in Tissues of Rats Fed Orotic Acid.  

차재영 (동아대학교 응용생명공학부)
전방실 (동아대학교 응용생명공학)
이영병 (동아대학교 식물생명공학)
박진철 (동아대학교 응용생명공학)
조영수 (동아대학교 응용생명공학부)
Publication Information
Journal of Life Science / v.14, no.4, 2004 , pp. 541-546 More about this Journal
Abstract
The antioxidative activities of capsaicin (Cap, 0.02 and 0.04%) on the lipid peroxidation of tissues in male Sprague Dawley rats fed diets with or without orotic acid (1.0%, w/w) were studied in vivo system by measuring thiobarbituric acid reactive substances (TBARS) concentrations. Body weight gain, food intakes, food efficiency ratio and the relative tissues weights of brain, kidney, spleen, heart, and testis were not significantly different among dietary groups. Relative weights of liver were higher in the OA group than that in the other groups. TBARS concentrations in liver were significantly higher in the OA or 0.04% Cap groups than in the normal group, while this raise was not observed 0.02% Cap group. A significant increase in TBARS concentrations was found in the liver of the OA +0.04% Cap group compared with the OA or the 0.04% Cap groups. Nonheme iron concentrations were significantly higher in the liver of the OA, 0.04% Cap, OA+0.02% Cap, OA+0.04% Cap groups than that in the normal group. TBARS concentrations in kidney were lower in the 0.02% or 0.04% Cap groups than that in the normal group, but this concentrations were higher in either the OA, OA+0.02% Cap or OA+0.04% Cap groups than that in the normal group. Meanwhile, TBARS concentrations of brain, spleen, heart and testis were not significantly different among groups. The present study suggested that the lipid peroxidation was increased in the rats liver fed diet with erotic acid, and the simultaneous supplementation of capsaicin further enhanced.
Keywords
capsaicin; erotic acid; TBARS; nonheme iron;
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