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http://dx.doi.org/10.5352/JLS.2004.14.3.514

Antioxidative Effects of Mushroom Extract and Fermented Milk Containing Its Extract on in vivo and in vitro Lipid Peroxidation  

차재영 (㈜바이오허브)
전병삼 (㈜바이오허브)
박정원 (㈜바이오허브)
신갑균 (㈜바이오허브)
김범규 (㈜바이오허브)
배동원 (㈜바이오허브)
유지현 (동아대학교 응용생명공학부)
전방실 (동아대학교 응용생명공학부)
조영수 (동아대학교 응용생명공학부)
Publication Information
Journal of Life Science / v.14, no.3, 2004 , pp. 514-520 More about this Journal
Abstract
The antioxidative effects of fermented milk, mushroom extract and fermented milk containing its extract (Lentinus edodes, Ganoderna lucidum, and Pleurotus ostreatus) on the lipid peroxidation in the tissues of female Sprague-Dawley rats and on the DPPH ($\alpha,\alpha$' -diphenyl-$\beta$-picrylhydrazyl) radical donating ability were studied. The total concentrations of polyphenolic compound in Lentinus edodes, Ganoderma lucidum and Pleurotus ostreatus were 0.34, 0.20 and 0.34%, respectively. The DPPH donating abilities of mushroom extract, fermented milk, fermented milk containing its extract and BHT (butylated hydorxytoluene) as standard were 33.9, 34.9, 51.9 and 95.6%, respectively. Experimental diet groups were divided into five groups: the normal diet (ND), the cholesterol diet (CD), and cholesterol + fermented milk diet (CDFM), cholesterol + mushroom extract diet (CDME) and cholesterol + fermented milk containing mushroom extract diet (CDFMME). The concentrations of lipid peroxide in liver and its microsome were significantly lower in both CDFM and CDFMME groups than in the other groups. The kidney concentration of lipid peroxide was significantly higher in the CD group than in the ND group, but this rise were significantly decreased in the CDFM and CDFMME groups. Meanwhile, the concentrations of heart and spleen and their fractions were not significantly different among dietary groups. This study was suggested that the fermented milk diet containing mushroom extract effectively reduced the lipid peroxidation in liver and kidney of cholesterol-fed female rats.
Keywords
fermented milk; lipid peroxidation; mushroom; DPPH;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
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