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http://dx.doi.org/10.5352/JLS.2004.14.2.356

The Effect of Porphyra tenera Extract on Serum Lipid Content in Ovariectomized Rats  

한희선 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터)
배송자 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터)
김미향 (신라대학교 식품영양학과 및 마린-바이오기능성소재산업화지원센터)
Publication Information
Journal of Life Science / v.14, no.2, 2004 , pp. 356-361 More about this Journal
Abstract
The aim of this study is to evaluate the effect of Porphyra tenera (PT) extract on serum lipids content in ovariectomized rats. From day 3 until 42 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovarjectomized rats supplemented with PT at 50 mg/kg bw/day (OVX-PT50), 200 mg/kg bw/day (OVX-PT200). The PT ethanol extract were orally administrated at 1 m1 per day. Body weight gain, food intake and food efficiency ratio were not significantly different between groups. Although total-cholesterol was increased in OVX-control, supplementation with the PT decreased the level of cholesterol in serum. Especially, it was significantly decreased in OVX-PI50 (p<0.05). Triglyceride was significantly decreased to almost all of groups supplemented with PT (p<0.05). The levels of HDL-cholesterol was higher in PT extract group than OVX-control. These results suggest that supplementation with the PT extract positively influenced on lipid concentration in serum. Consequently, we expect that PT extract decrease risk of cardiovascular diseases by postmenopausal.
Keywords
Porphyra tenera; ovariectomized rat; serum lipids;
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