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http://dx.doi.org/10.5352/JLS.2004.14.2.209

Effects of Chitosan on Anti-tumor Activity in Mice  

정양숙 (고신대학교 의과대학 미생물학교실)
김광혁 (고신대학교 의과대학 미생물학교실)
정영기 (동의대학교 자연과학대학 생명응용과학과)
장명웅 (고신대학교 의과대학 미생물학교실)
Publication Information
Journal of Life Science / v.14, no.2, 2004 , pp. 209-214 More about this Journal
Abstract
Cytotoxic anticancer chemotherapeutic agents generally produce severe side effects, while reducing host resistance to cancer and infections, especially through the destruction of lymphoid and bone marrow cells. In this study, we have investigated the effect of chitosan on cytotoxic activity against cancer cells and life span in mice. The direct cytotoxicity of chitosan or chitosan-combinated chemotherapeutic agents for tumor cells was observed. In addition, the effect of life span extention was counted on sarcoma 180 mice injected with chitosan-combinated mitomycin C. The effect of growth inhibion for cancer cells, K562 and Yac-1 was shown in the cytotoxicity test of chitosan or chitosan-combinated chemotherapeutic agents. Also, the effect of life span extension was observed on sarcoma 180 mice injected with chitosan-combinated mitomycin C. Our results suggest that life span extension in sarcom 180 mice exposed with chitosan-combinated chemotherapeutic agents showed the probability of its usefulness for cancer therapy if more research results were accumulated.
Keywords
Chitosan; Cytotoxicity; Life span;
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