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http://dx.doi.org/10.5352/JLS.2003.13.6.911

Protective effects of Opuntia ficus-indica on Glutathione and Antioxidative Enzyme  

전홍기 (부산대학교 생명과학부)
정영기 (동의대학교 생명응용과학과)
하배진 (신라대학교 생명공학과)
Publication Information
Journal of Life Science / v.13, no.6, 2003 , pp. 911-916 More about this Journal
Abstract
The effects of Opuntia ficus-indica (OF) administration on the biochemical parameters of function in liver tissue and serum of $CCl_4$ treated rats were investigated. Opuntia ficus-indica (200 mg/kg) was administered into rats intraperitoneally for two weeks. $3.3m\ell$ of $CCl_4$$_4$ (50% $CCl_4$ : Olive oil = 1 : 1) was treated to rats on the 14th day and 15th day and they were operated on 15th day. We examined the antioxidative enzymatic activity by measuring the level of AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), GSH (Glutathione reduced form), GSSG (Glutathione oxidezed form), GPx (GSH-peroxidase), SOD (Superoxide dismutase) and CAT (Catalase) in serum and liver tissue of rats. OFC administered group showed 24.8% of inhibitory effect in AST activity compared to $CCl_4$ -treated abnormal group (CTA). ALT level of OF administered group was decreased by 60.7% to the level of CTA. GSH, GSSG and GPx of OFC administered group were significantly higher than those of CTA group. SOD and CAT in OFC administered group were increased by 28.3% and by 16.9% respectively compared to those of CTA group.
Keywords
Opuntia ficus-indica; Hepatotoxicity; Antioxidative enzyme; Glutathione;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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