Biosynthesis of Polyketide Secondary Metabolites |
윤여준
(울산대학교 공과대학 생명화학공학부)
송재경 (선문대학교 자연과학부, 생체분자재설계연구소) |
1 |
Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host
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2 |
Daunorubicin type Ⅱ polyketide synthase enzymes DpsA and DpsB determine neither the choice of starter unit nor the cyclization pattern of aromatic polyketides
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DOI ScienceOn |
3 |
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
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DOI |
4 |
Gain-of -function mutagenesis of a modular polyketide synthases
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DOI ScienceOn |
5 |
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis
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6 |
Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis
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7 |
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin
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DOI ScienceOn |
8 |
Rational Design and Engineered Biosynthesis of a Novel 18-Carbon Aromatic Polyketide
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9 |
Organization of the enzymatic domains in the mutifuctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea
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10 |
Manipulation of modular polyketide synthase
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11 |
Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase
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DOI ScienceOn |
12 |
Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system
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DOI ScienceOn |
13 |
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.
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14 |
The tcmⅥ region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase
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15 |
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits
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DOI ScienceOn |
16 |
Biosynthesis of 6-methylsalicylic acid
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DOI ScienceOn |
17 |
Iterative type Ⅱ polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides
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18 |
Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities
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DOI ScienceOn |
19 |
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus
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DOI |
20 |
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
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DOI ScienceOn |
21 |
Engineered biosynthesis of novel polyketides
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DOI |
22 |
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
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DOI ScienceOn |
23 |
Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor
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DOI |
24 |
The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum.Its gene structure relative to that of other polyketide synthases
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DOI ScienceOn |
25 |
Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis
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26 |
Structure and deduced function of the granaticin-producing polykitide synthase gene cluster of Streptomyces violaceoruber Tu22
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27 |
Biosynthesis of desosamine-Construction of a new methymycin/neomethymycin analogue by deletion of a desosamine biosynthetic gene
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28 |
Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor
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DOI ScienceOn |
29 |
Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus
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DOI |
30 |
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230
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DOI ScienceOn |
31 |
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharospolyspora erythraea
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32 |
Engineered biosynthesis of triketide lactone from an incomplete modular polyketide synthase
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33 |
The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides
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34 |
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35 |
Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins
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DOI |
36 |
Engineered biosynthesis of a complete macrolactone in a heterologous host
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37 |
Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precurson
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38 |
Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus
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39 |
Modular organization of the genes required for complex polyketide biosynthesis
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40 |
A second type-ⅠPKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain
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41 |
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
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42 |
Polyketide synthesis: prospects for hybrid antibiotics
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43 |
A multiplasmid approach to preparing large libraries of polyketides
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44 |
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
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DOI ScienceOn |
45 |
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmⅠ genes provides key information about the enzymology of polyketide antibiotic biosynthesis
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46 |
Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome
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DOI ScienceOn |