Browse > Article
http://dx.doi.org/10.5352/JLS.2002.12.5.549

Taraxacum mongolieum Hand-Mass Aqua-acupuncture Solution as the Blocking Agent of Carcinogenesis  

손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터)
김소연 (동국대학교 한의과대학 경혈학교실)
임종국 (동국대학교 한의과대학 경혈학교실)
남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터)
Publication Information
Journal of Life Science / v.12, no.5, 2002 , pp. 549-554 More about this Journal
Abstract
Taraxacunf mongofieum Hand-Mass aqua-acupuncture solution (TMAS) was prepared and investigated og, the effect on initiation of carcinogenesis. The following effe.Is as a blocking agent were measured. .(a) Indu.ction of quinone reductase, (b) Induction of glutathione S-transferase activity (c) Increase of reduced glutathione. TMAS was potent inducer of quinone reductase in Hepa Iclc7 murine hepatoma cells. Clutathione S-transferase activity was increased with TMAS. In addition glutathione levels were increased about 1.6-fold with TMAS in cultured murine hepatoma Hepa Iclc7 cells.
Keywords
Tarnxacum mongolieum Hand-Mass aqua-acupuncture solution; quinone reductase; glutathione S-transferase, glutathi one;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Glutathione S-transferase : the first enzymatic step mercapturic acid formation /
[ Habig, W. H.;M. H. Pabst;W. B. Jacoby ] / J. Biol. Chem.
2 Screening of potential chemopreventive agents using biochemical markers of carcinogenesis /
[ Sharma, S.;J. D. Stutzman;G. J. Kelloff;V. E. Steele ] / Cancer Res.
3 Interaction of glutathione with reactive intermediates /
[ Molders, P.;B. Jernestrom;Larson, A.(ed.);S. Orrenius(ed.);A. Holgren(ed.);B. Mannervik(ed.) ] / Functions of Glutathione: Biochemical, Physiological, and Clinical Aspects
4 Direct measurement of NAD(P)H : Quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers /
[ Prochaska, H. J.;A. B. Santamaria ] / Anal. Biochem.   DOI   ScienceOn
5 Glutathione /
[ Meister, A.;M. Anderson ] / Ann. Rev. Biochem.   DOI   ScienceOn
6 Chemoprevention of oral carcinogenesis by D,L-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasmas in rats /
[ Tanaka, T.;T. Kojima;A. Hara;H. Sawada;H. Mori ] / Cancer Res.
7 Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase Ⅱ drug-metabolizing enzymes /
[ Gerhauser, C.;M. You;J. Liu;R. M. Moriarty;M. Hawthorne;R. G. Mehta;R. C. Moon;J. M. Pezzuto ] / Cancer Res.
8 Chemoprevention of cancer /
[ Sporn, M. B. ] / Lancet   DOI   ScienceOn
9 Chemoprevention of cancer /
[ Wattenberg, L. W. ] / Cancer Res.   DOI
10 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine /
[ Griffith, O. W. ] / Anal. Biochem.   DOI   ScienceOn