Browse > Article
http://dx.doi.org/10.5352/JLS.2002.12.4.442

Bromate Formation by Ozonation Process and It′s Effect on Renal Toxicity in rat  

정운용 (경성대학교 환경문제연구소)
이무강 (경성대학교 환경문제연구소)
최종원 (경성대학교 환경문제연구소)
Publication Information
Journal of Life Science / v.12, no.4, 2002 , pp. 442-451 More about this Journal
Abstract
In oder to investigate the effects of pH and temperature on the formation of bromate ion, which is ozonation by-products of bromine containing natural water. At the same intial pH condition, the increase of pH shown similar trends even if the reaction variables such as temperature and reaction time of ozonation were changed. As pH and temperature were increasing, the bromate concentration was increased but bromine components (HOBr/OBr-) were decreased with increasing pH from 3 to 10. Lipid peroxide content in the kidney was increased by bromate which was ingestion with 0.4g/L for 24 weeks in drinking water. Renal cytosolic enzyme system (XO, AO) of bromate group were significantly increased in comparison with those of normal group. But microsomal enzyme system were not affected. BUN level and urinary ${\gamma}$-glutamyltransferase activity were significantly increased in comparison with those of the normal. But, urinary lactate dehydrogenase activity was not affected. Renal glutathione content of rat was significantly decreased in comparison with those of normal rat given bromate. Renal glutathione S-transferase and ${\gamma}$-glutamylcysteine synthetase activities were significantly decreased in bromate-treated group, but change in renal glutathione reductase activity was not significantly different from any other experimental group.
Keywords
eromate; Renal toxicity; xanthine oxidase; $\gamma$-glutamylcysteine synthetase;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Erthrocyte glutahione reductase activity in chronic renal disease /
[ Ferrone,S.;A.Zanella;G.Sirchia ] / Scand.J.Haematol   DOI
2 Decomposition of Ozone in Water in the Presence of Organic Solutes Acting as Promotors and Inhibitors of Radical chain Reaction /
[ Johannes.S;J.Hoine ] / Environ.Sci.Technol   DOI   ScienceOn
3 An experimental model for hydro peroxide induced tissue damage:Effect on cartilage and other articular tissues /
[ Schlkwjik,J.;W.B.Vandenberg;L.B.A.Vandeputte;L.B.A.Loosten ] / Int.J.Tiss.Reac
4 Toxicity and Carcinogenicity of Potassium Bromate,-A Renal Calcinogen /
[ Yuji K. ] / Health Prespectitives   DOI   ScienceOn
5 /
[ David,J.;L.S.Vernon ] / Water chemistry
6 Bromate ion Formation Inhibition by Coexting Organic Matters in Ozonation Process /
[ Mari.A.;A.Takako;M.Yasumoto ] / Japan Society on Water Environment   DOI   ScienceOn
7 Glutathione S-transferase: The first enzymatic step in mercapturic acid formation /
[ Habig,W.H.;M.J.Pabist;W.B.Jakoby ] / J.Biol.Chem
8 Mechanistic toxicology :A radical perspective /
[ Ross,D. ] / J.Pharm.Pharmacol   DOI
9 Chlorine-Ozone Interactions:Formation of Chlorate /
[ Mohamed S.. ] / Wat.Res.   DOI   ScienceOn
10 Detection of hydroxy radicals upon interaction of ozone with aqueous media or extracellular surfactant:tje role of trace iron /
[ Byveot,P.;J.U.Balis;S.A.Shelly;M.R.Montgomery;M.J.Barber ] / Arch.Biochem.Biophys.   DOI   ScienceOn
11 Deafness and renal failure due to potassium bromate poisoning /
[ Quick,C.A.;R.A.Chole;M.Mauer ] / Arch.Otolaryngol   DOI
12 Role of oxygen radicals in the pathognesis intestinal inschmia /
[ Granger,D.N.D.A.Parks ] / The Phamacologist
13 Ozonaiton Products of Bromine and Chlorine in Sea-water Aquaria /
[ Gordan G.'H.T.John;J.J.Leaffaber ] / Wat.Res.   DOI   ScienceOn
14 Bromete Formation during Ozonation of Bromide containg Water:Interaction of Ozone and Hydorxyl radical Reaction /
[ Gunten.U.V.;J.Hoigen ] / Environ.Sci.Tech.   DOI   ScienceOn
15 Improved Ammonia Oxidation by Ozone in the Presence of Bromide Ion During Water Treatement /
[ Hagg,W.R.;J.Hoine;H.Bader ] / Wat.Res.   DOI   ScienceOn
16 Glutathione peroxidase activity in selenium deficient rat liver /
[ Lawrence,R.A.;R.F.Burk ] / Biochem.Biophys.Res.Cmmum   DOI   ScienceOn
17 Hydrogen peroxide causes the fetal injury to human fibroblasts exposed to oxygen radicals /
[ Simon.R.H;C.M.Scoggin;D.Patterson ] / J.Biol.Chem
18 On the behaivior of anionic detergents in ozone-treated water /
[ Verde,L.;F.Meucci:G.C.Vanini ] / Ig.Mod
19 Studies of aldhyde oxidase by electron paramagnetic resonance spectroscopy /
[ Rajagopalan,K.V.;P.Handler;G.Plamer;H.Benert ] / J.Biol.Chem
20 Urinary gamma-glutamyl transpeptidase, an indicator of renal ischaemic injury and homogate rejection /
[ Ward,J.P. ] / Br.J.Urol   DOI   ScienceOn
21 Biololgy of disease:Free radicals and tissue injury /
[ Freeman,B.A.;J.D.Crapo ] / Lab.Invest
22 Ozonation of Bromide-Containing Waters;Kinetics of Formation of hypobormous Acid and Bromate. /
[ Werner R.H.;J.Hoigne ] / Environ.Sci.Technol   DOI   ScienceOn
23 Sensorial and microbial effects of gaseous ozone on fresh scad /
[ da Silva;M.V.;P.A.Gibbs;R.M.Kirby ] / J.Appl.Microbiol   DOI   ScienceOn
24 A Kinetic photometric method for serum γ-glutamyltransferase /
[ Szasz,F. ] / Clin.Chem
25 Acute ethanol exposure alters hepatic glutatione metabolism in riboflavin deficiency /
[ Dutta,P.;J.Seirafi;D.Halpin;J.Pinto;R.Rivlin ] / Alcohol   DOI   ScienceOn
26 The effects of bromate ion formation by ozonation process and mechanism of biological toxicity due bromate in rat /
[ Chung,U.Y.; ] / Ph.D.thesis
27 Changes in the urinary enzyme activity in some kidney disease /
[ Straus,B.;M.Prejac;I.Cepelak;B.Kunovic:K.Lipovac ] / Vojnodsanit Pergl
28 /
[ Milan,L.;R.Jozof;K.Vilian;P.Peter;V.Ladislav ] / Radicals in Chemistry and Biololgy
29 New,sensitive and selective method for determining sub-microgam/1 levels of bromate in drinking water /
[ Weinberg.H.S.;H.Yamada;R.J.Joyce ] / J.Chromatogr.   DOI   ScienceOn
30 The carbon monooxide binding pigments of liver microsomes In: Evidence for its hemoprotein nature /
[ Omura,T.;R.Sato ] / J.Biol.Chem
31 The effects of oxidant stress on human lympyocyte cutotoxicity /
[ Gerver,M.R.;V.N. Thompson;S.D.Balcerzak;A.L.Jr.Sagone ] / Blood
32 Free radicals and inflammation:Protection of synovial fluid by superoxide dismutase /
[ Mccord J.M. ] / Science   DOI   ScienceOn
33 Role of gamma glutamyl transpepetidase activity in the diagnosis of hepatobiliary disease /
[ Goldberg,D.M.;J.D.Martin ] / Digestion   DOI
34 Oxidants and human disease:Some new concepts /
[ Halliwell,B ] / Fase.J.
35 Multiple drug metabolism:P-nitroanisole reversal of acetone enhanced aniline hydroxylation /
[ Bidlack,W.R.;G.L.Lowery ] / Biochem.Pharmacol   DOI   ScienceOn
36 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction /
[ Ohkawa,H.;N.Ohishi;K.Yahi ] / Anal.Biochem   DOI   ScienceOn
37 Biological defense mechanisms:The production by leukocytes of superoxide, a potential bactericidal agent /
[ Babior,B.M.;R.S.Kipnes;J.T.Curnutte ] / J.Clin.Invest.   DOI
38 Oxygen radicals and human disease /
[ Cross,C.E.;H.Barry;T.B.Edward;A.P.William;N.A.Bruce,L.S.Robert;M.M.Joe;H.Denham ] / Ann.Intern.Med   DOI   ScienceOn
39 Protein measurement with folin phenol reagent /
[ Lowry.O.H.;N.J.Rosebrough;A.L.Farr;R.J.Rendall ] / J.Biol.Chem
40 Regulation of gramma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione /
[ Richman,P.G.;A.Meister ] / J.Biol.Chem
41 Proteinase inhibitors suppress the formation of granulation tissue in the carrageenin-induced inflammation /
[ Nakagawa,H.;K.Shuto;M.Isaji;K.Watanabe ] / J.Pharmacobio.Dyn   DOI
42 Removal of Aromatic Nitro Compounds From Water by Ozone /
[ Wang B.;Y.jin ] / Ozone Science&Engineering   DOI   ScienceOn
43 Inhibition of purified rat liver glutatione S-transferase isozymes by diuretic drugs /
[ Ahokas,J.T.;F.A.Nichollas;P.J.Raverscroft;B.T.Emmerson ] / Biochem.Pharmacol   DOI   ScienceOn
44 Use of a mixture of a phenol reagent and a urease in the urease-indophenol method(analysis of blood urea nitrogen) /
[ Uchida,K.;K.Tejima ] / Rinsho.Byori
45 The colorimetric estimation of form-aldehyde by means of the hentisch reaction /
[ Nash,T ] / J.Biol.Chem
46 Melatonin protects against oxidative stress induced by kidney carcinogen KBrO3 /
[ El-Sokkary.G.H. ] / Neuroendocrinol,Lett
47 The regulation of rat liver xanthine oxidase:Conversion in vitro of the emzyme activity from dehydrogenase(Type D) to oxidase(type 0) /
[ Stripe,F.;C.E.Della ] / J.Biol.Chem
48 Activities of several phase I and phase Ⅱ xenobiotics biotranformation enzyme in cultured hepatocytes from male and female rats /
[ Ahokas,J.T.;F.A.Nichollas;P.J.Raverscroft;B.T.Emmerson ] / Biochem.Pharmacol   DOI   ScienceOn
49 Level of dehydrogenase activity in chipmunks under normal conditions and during chronic external gamma-irradiation /
[ Kudiasheva,A.G.;A.I.Taskaev ] / Radiobiologia
50 Bromate minimization during ozonation :nechanistic condiderations /
[ Pinkernell,U.;U.V.Gunten ] / Environ.Sci.Technol   DOI   ScienceOn
51 A mechanism for the production of ethlene form methionine:The generation of the hydroxyl radical by xanthine oxidase /
[ Beauchamp,C.;Fridovich ] / J.Biol.Chem
52 Evidence for the role of environmental agents in the initiation or progression of autommune conditions /
[ Powell,J.J.;J.Van de Water;M.E. Gershwin ] / Health Perspect
53 Diminished rates of glucuronidation and sulfation in perfused rat liver after chroic ethanol administration /
[ Reinke.L.A.;M.J.Meyer;K.A.M.Notley ] / Biochem.Pharmacol   DOI   ScienceOn