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http://dx.doi.org/10.5352/JLS.2002.12.3.306

Effect of Transplantation of Intravascular Cultured Neural Stem Cell upon Peripheral Nerve Regeneration  

양영철 (인제대학교 의과대학 해부학교실)
김우일 (인제대학교 의과대학 해부학교실)
박중규 (인제대학교 의과대학 해부학교실)
배기원 (인제대학교 의과대학 해부학교실)
Publication Information
Journal of Life Science / v.12, no.3, 2002 , pp. 306-316 More about this Journal
Abstract
The ultrastructural change of sciatic nerve and immunohistochemical changes of NGF, PCNA were studied at the transplanted segment of intravascular cultured neural stem cell in the rat sciatic nerve by 5 months after the sciatic nerve transection. The transplanted intravascular neural stem cells were differentiated into Schwann reals at the 20th day and these cells began to regenerate by the proliferation and hypertrophy. There were many remyelinating Schwann cells in the transplanted nerve in term of stimulation. According to NGF finding, we suggest preexisting Schwann cells may induce the differentiation of neural stem cells into regenerating Schwann cells. Electron microscopic changes were the remyelinating appearance, the increase of intraaxonal microtubules and enlarged mitochondria and contacting tell processes each other.
Keywords
Intravascular cultured neural stem cell; NGF; PCNA; electron microscopic changes;
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