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http://dx.doi.org/10.5352/JLS.2002.12.3.281

Biotransformation of Arylnitroso Compound by Mammalian 1,4-Benzoquinone Reductase  

김경순 (명지대학교 화학과)
신해용 (명지대학교 화학과)
Publication Information
Journal of Life Science / v.12, no.3, 2002 , pp. 281-287 More about this Journal
Abstract
Quinone reductase was purified to homogeneity from bovine liver and the purified enzyme catalyzed the reduction of phenanthrenequinone as well as benzo- and naphthoquinones. The enzyme catalyzed the biotransformation of arylnitroso nitroso compound and the reaction product was identified by TLC, GC, CC-MS and NMR. The reaction was almost entirely inhibitable by Cibacron blue 3GA or dicumarol, potent inhibitors of mammalian quinone reductase.
Keywords
arylnitroso nitroso compound; biotransformation; enzyme;
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