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http://dx.doi.org/10.5352/JLS.2002.12.2.208

Effect of Neighbor Base Sequences on the Base Pair Stabilities at d(CXG) and d(GXC) in Human ε-globin Promoter  

Chung, In-Ae (Department of Chemistry, Kyungwon university)
Gang, Jong-Back (Department of Chemistry, Kyungwon university)
Publication Information
Journal of Life Science / v.12, no.2, 2002 , pp. 208-212 More about this Journal
Abstract
Human $\varepsilon$-globin DNA fragment was used to determine the thermal stabilities of base pairs at d(CXG) and d(GXC) by Temperature Gradient Gel Electrophoresis(TGGE). The base pair stability depends on the hydrogen bonding interaction and base stacking interaction of neighbor base sequence. The orders of base pair stabilities were T.AG.A = A.G>C.T>T.C>C.A>A.C for d(GXC).d(GYC).
Keywords
base pair stability; Mutation detection; Temperature Gradient Gel Electrophoresis(TGGE);
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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