Browse > Article
http://dx.doi.org/10.5352/JLS.2002.12.2.182

Extracts of Caesalpina sappan L. Potentiate the Apoptosis of NIH3T3 Cells Exposed to Methymethane Sulfonate  

박종군 (원광대학교 자연대 생명과학부)
황성진 (원광대학교 자연대 생명과학부)
이정섭 (조선대학교 자연대 생물과학부)
전병훈 (원광대학교 한의과대학)
김원신 (원광대학교 자연대 생명과학부)
Publication Information
Journal of Life Science / v.12, no.2, 2002 , pp. 182-187 More about this Journal
Abstract
In this study we have investigated the effect of Caesalpina sappann L. extracts on the apoptosis in NIH3T3 cells exposed to methylmethan sulfonate (MMS), an alkylating agent. MTT assay study showed that Caesalpina sappan L. extracts potentiate the MMS-induced viability. Cell morphology studies, acridine orange (AO) staining, and DNA fragmentation analysis indicated that the postincubation of Caesalpina sappan L. extracts increase the nuclear condensation of MMS-induced apoptotosis. These results suggest that Caesalpina sampan L. extracts contain components potentiating MMS-induced apoptosis of NIH3T3 cells.
Keywords
Caesalpina sappan L.; MMS; apoptosis; NIH3T3;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Brazilin protects cultured rat hepatocytes from BrCCI3-induced toxicity /
[ Moon;C. K.;K. S. Park;S. G. Kim;H. S. Won;J. H. Chung ] / Drug and Chemical Toxicology   DOI   ScienceOn
2 /
[ 전국한의과대학 본초학교수 ] / 본초학
3 Treatment of intestinal metaplasia and atypical thperplasia of gastric mucosa with xiao wei yan powder /
[ Liu;X. P.;W. Q. Han;D. R. Sun. ] / Chung-Kuo Chung Hsi I Chieh Ho Tsa Chih
4 Vasorelaxing effectsof Caesalpinia sappan involvement of endogenous nitric oxide /
[ Xie;Y. W.;D. S. Ming;H. X. Xr;H. Dong;P. P. But ] / Life Sci.   DOI   ScienceOn
5 /
[ 김창민;신민교;이경순;안덕규 ] / 중약대사전
6 Feasibility of drug screening with panels of human tumor cell lines using a microculture terazolium assay /
[ Alley;M. C.;M. L. Hursey;R. H. Shoemarker;J. G. Czerwinski;D. L. Fine;B. J. Abbott ] / Cancer Res
7 Antioxidative activity of some solvent extract from Caesalpinia sappan L. /
[ Lim;D. K.;L. U. Choi;D. H. Shin ] / Kor. J. Food Sci. Tenhnol.
8 /
[ 장상문;최정;김종원;박병윤;박선동 ] / 한약자원식물학
9 Homoisoflavoids and related compound. Ⅳ. Absolute comfigurations of homoisoflavonoids from Caesalpinia sappan L. /
[ Namikosi;M.;T. Saitoh ] / Chem. Pharm. Bull
10 Classical mutagenesis techinques /
[ Lawrence;C. W. ] / Method Enwymol   DOI
11 Cytotoxic effectof Korean traditional prescription on the human gastric cancer cell lines /
[ Park;K. J.;E. H. Kim;Y. A. Eun;B. J. Kang;H. J. Sung ] / Kor. J. Pharmacogn
12 Brazillin modulates immine function mainly by augmenting T cell activity in halothane adminstered mice /
[ Choi;S. Y.;K. M. Yang;S. D. Jeon;L. Y. Kim;T. S. Chang;C. K. Moon ] / Planta Medica   DOI   ScienceOn
13 /
[ 신문농출판공가 ] / 중약대사전
14 Anticomplementary activity of comstituents from the heartwood of Caesalpinia sappan /
[ Oh;S. R.;D. S. Kim;I. S. Lee;K. Y. Jung;J. J. Lee;H. K. Lee ] / Planta Medica   DOI   ScienceOn
15 In vitro studies on the anticancer effect and topoisomerase I inhibition activity of Caesalpinia sappan L. /
[ Jeon;W. K.;K. J. Park;S. Y. Kim;J. Y. Ma;H. J. Sung ] / extract. Kor. J. Pharmacogn.
16 Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli /
[ Taverna;P.;B. Sedgwichk ] / J. Bacterial
17 Antimicrobial activity of ethanol of Caesalpina sappan L. and Effect of the extract on the fermentation of Kimchi /
[ Lee;S. H.;W. J. Choi;O. K. Jo;S. J. Son. ] / J. Food Sci. and Technol.