Browse > Article
http://dx.doi.org/10.3340/jkns.2020.0039

Retethering : A Neurosurgical Viewpoint  

Lee, Ji Yeoun (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital)
Kim, Kyung Hyun (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital)
Park, Kwanjin (Division of Pediatric Urology, Seoul National University Children's Hospital)
Wang, Kyu-Chang (Division of Pediatric Neurosurgery, Seoul National University Children's Hospital)
Publication Information
Journal of Korean Neurosurgical Society / v.63, no.3, 2020 , pp. 346-357 More about this Journal
Abstract
During the follow-up period after surgery for spinal dysraphism, a certain portion of patients show neurological deterioration and its secondary phenomena, such as motor, sensory or sphincter changes, foot and spinal deformities, pain, and spasticity. These clinical manifestations are caused by tethering effects on the neural structures at the site of previous operation. The widespread recognition of retethering drew the attention of medical professionals of various specialties because of its incidence, which is not low when surveillance is adequate, and its progressive nature. This article reviews the literature on the incidence and timing of deterioration, predisposing factors for retethering, clinical manifestations, diagnosis, surgical treatment and its complications, clinical outcomes, prognostic factors after retethering surgery and preventive measures of retethering. Current practice and opinions of Seoul National University Children's Hospital team were added in some parts. The literature shows a wide range of data regarding the incidence, rate and degree of surgical complications and long-term outcomes. The method of prevention is still one of the main topics of this entity. Although alternatives such as spinal column shortening were introduced, re-untethering by conventional surgical methods remains the current main management tool. Re-untethering surgery is a much more difficult task than primary untethering surgery. Updated publications include strong skepticism on re-untethering surgery in a certain group of patients, though it is from a minority of research groups. For all of the abovementioned reasons, new information and ideas on the early diagnosis, treatment and prevention of retethering are critically necessary in this era.
Keywords
Lumbosacral lipoma; Myelomeningocele; Retethering; Incidence; Outcome;
Citations & Related Records
연도 인용수 순위
  • Reference
1 George TM, Fagan LH : Adult tethered cord syndrome in patients with postrepair myelomeningocele: an evidence-based outcome study. J Neurosurg 102(2 Suppl) : 150-156, 2005   DOI
2 Goodrich DJ, Patel D, Loukas M, Tubbs RS, Oakes WJ : Symptomatic retethering of the spinal cord in postoperative lipomyelomeningocele patients : a meta-analysis. Childs Nerv Syst 32 : 121-126, 2016   DOI
3 Grande AW, Maher PC, Morgan CJ, Choutka O, Ling BC, Raderstorf TC, et al. : Vertebral column subtraction osteotomy for recurrent tethered cord syndrome in adults : a cadaveric study. J Neurosurg Spine 4 : 478-484, 2006   DOI
4 Haberl H, Tallen G, Michael T, Hoffmann K, Benndorf G, Brock M : Surgical aspects and outcome of delayed tethered cord release. Zentralbl Neurochir 65 : 161-167, 2004   DOI
5 Hayashi T, Takemoto J, Ochiai T, Kimiwada T, Shirane R, Sakai K, et al. : Surgical indication and outcome in patients with postoperative retethered cord syndrome. J Neurosurg Pediatr 11 : 133-139, 2013   DOI
6 Herman JM, McLone DG, Storrs BB, Dauser RC : Analysis of 153 patients with myelomeningocele or spinal lipoma reoperated upon for a tethered cord. Pediatr Neurosurg 19 : 243-249, 1993   DOI
7 Kanno H, Aizawa T, Ozawa H, Hoshikawa T, Itoi E, Kokubun S : Spineshortening vertebral osteotomy in a patient with tethered cord syndrome and a vertebral fracture. Case report. J Neurosurg Spine 9 : 62-66, 2008   DOI
8 Kim KH, Chong S, Lee JY, Kim SK, Cho BK, Wang KC : A Method of untethering by skipping the area of positive responses on electrical stimulation during surgery of lumbosacral lipomatous malformation : "hopping on a stepping stone". World Neurosurg 124 : 48-51, 2019   DOI
9 Kokubun S, Ozawa H, Aizawa T, Ly NM, Tanaka Y : Spine-shortening osteotomy for patients with tethered cord syndrome caused by lipomyelomeningocele. J Neurosurg Spine 15 : 21-27, 2011   DOI
10 Lam WW, Ai V, Wong V, Lui WM, Chan FL, Leong L : Ultrasound measurement of lumbosacral spine in children. Pediatr Neurol 30 : 115-121, 2004   DOI
11 Martinez-Lage JF, Ruiz-Espejo Vilar A, Almagro MJ, Sanchez del Rincon I, Ros de San Pedro J, Felipe-Murcia M, et al. : Spinal cord tethering in myelomeningocele and lipomeningocele patients: the second operation. Neurocirugia (Astur) 18 : 312-319, 2007   DOI
12 Lee JY, Phi JH, Cheon JE, Kim SK, Kim IO, Cho BK, et al. : Preuntethering and postuntethering courses of syringomyelia associated with tethered spinal cord. Neurosurgery 71 : 23-29, 2012   DOI
13 Lin W, Xu H, Duan G, Xie J, Chen Y, Jiao B, et al. : Spine-shortening osteotomy for patients with tethered cord syndrome : a systematic review and meta-analysis. Neurol Res 40 : 340-363, 2018   DOI
14 Maher CO, Goumnerova L, Madsen JR, Proctor M, Scott RM : Outcome following multiple repeated spinal cord untethering operations. J Neurosurg 106(6 Suppl) : 434-438, 2007
15 Mehta VA, Bettegowda C, Ahmadi SA, Berenberg P, Thomale UW, Haberl EJ, et al. : Spinal cord tethering following myelomeningocele repair. J Neurosurg Pediatr 6 : 498-505, 2010   DOI
16 Mehta VA, Gottfried ON, McGirt MJ, Gokaslan ZL, Ahn ES, Jallo GI : Safety and efficacy of concurrent pediatric spinal cord untethering and deformity correction. J Spinal Disord Tech 24 : 401-405, 2011   DOI
17 Meyrat BJ, Tercier S, Lutz N, Rilliet B, Forcada-Guex M, Vernet O : Introduction of a urodynamic score to detect pre- and postoperative neurological deficits in children with a primary tethered cord. Childs Nerv Syst 19 : 716-721, 2003   DOI
18 Ogiwara H, Lyszczarz A, Alden TD, Bowman RM, McLone DG, Tomita T : Retethering of transected fatty filum terminales. J Neurosurg Pediatr 7 : 42-46, 2011   DOI
19 Pang D, Zovickian J, Oviedo A : Long-term outcome of total and neartotal resection of spinal cord lipomas and radical reconstruction of the neural placode, part II : outcome analysis and preoperative profiling. Neurosurgery 66 : 253-272; discussion 272-273, 2010   DOI
20 Ostling LR, Bierbrauer KS, Kuntz C 4th : Outcome, reoperation, and complications in 99 consecutive children operated for tight or fatty filum. World Neurosurg 77 : 187-191, 2012   DOI
21 Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, et al. : Congenital lumbosacral lipomas. Childs Nerv Syst 13 : 298-334; discussion 335, 1997   DOI
22 Safain MG, Burke SM, Riesenburger RI, Zerris V, Hwang SW : The effect of spinal osteotomies on spinal cord tension and dural buckling: a cadaveric study. J Neurosurg Spine 23 : 120-127, 2015   DOI
23 Samuels R, McGirt MJ, Attenello FJ, Garces Ambrossi GL, Singh N, Solakoglu C, et al. : Incidence of symptomatic retethering after surgical management of pediatric tethered cord syndrome with or without duraplasty. Childs Nerv Syst 25 : 1085-1089, 2009   DOI
24 Schumacher R, Richter D : One-dimensional fourier transformation of M-mode sonograms for frequency analysis of moving structures with application to spinal cord motion. Pediatr Radiol 34 : 793-797, 2004   DOI
25 Tubbs RS, Oakes WJ : A simple method to deter retethering in patients with spinal dysraphism. Childs Nerv Syst 22 : 715-716, 2006   DOI
26 Segal LS, Czoch W, Hennrikus WL, Wade Shrader M, Kanev PM : The spectrum of musculoskeletal problems in lipomyelomeningocele. J Child Orthop 7 : 513-519, 2013   DOI
27 Sharma U, Pal K, Pratap A, Gupta DK, Jagannathan NR : Potential of proton magnetic resonance spectroscopy in the evaluation of patients with tethered cord syndrome following surgery. J Neurosurg 105(5 Suppl) : 396-402, 2006   DOI
28 Stamates MM, Frim DM, Yang CW, Katzman GL, Ali S : Magnetic resonance imaging in the prone position and the diagnosis of tethered spinal cord. J Neurosurg Pediatr 21 : 4-10, 2018   DOI
29 Tarcan T, Bauer S, Olmedo E, Khoshbin S, Kelly M, Darbey M : Long-term followup of newborns with myelodysplasia and normal urodynamic findings : is followup necessary? J Urol 165 : 564-567, 2001   DOI
30 Thuy M, Chaseling R, Fowler A : Spinal cord detethering procedures in children: a 5 year retrospective cohort study of the early post-operative course. J Clin Neurosci 22 : 838-842, 2015   DOI
31 Vassilyadi M, Tataryn Z, Merziotis M : Retethering in children after sectioning of the filum terminale. Pediatr Neurosurg 48 : 335-341, 2012   DOI
32 Walker CT, Godzik J, Kakarla UK, Turner JD, Whiting AC, Nakaji P : Human amniotic membrane for the prevention of intradural spinal cord adhesions: retrospective review of its novel use in a case series of 14 patients. Neurosurgery 83 : 989-996, 2018   DOI
33 Bowman RM, Mohan A, Ito J, Seibly JM, McLone DG : Tethered cord release: a long-term study in 114 patients. J Neurosurg Pediatr 3 : 181-187, 2009   DOI
34 Abrahamsson K, Olsson I, Sillen U : Urodynamic findings in children with myelomeningocele after untethering of the spinal cord. J Urol 177 : 331-334; discussion 334, 2007   DOI
35 Aldave G, Hansen D, Hwang SW, Moreno A, Briceno V, Jea A : Spinal column shortening for tethered cord syndrome associated with myelomeningocele, lumbosacral lipoma, and lipomyelomeningocele in children and young adults. J Neurosurg Pediatr 19 : 703-710, 2017   DOI
36 Yong RL, Habrock-Bach T, Vaughan M, Kestle JR, Steinbok P : Symptomatic retethering of the spinal cord after section of a tight filum terminale. Neurosurgery 68 : 1594-1601; discussion 1601-1602, 2011   DOI
37 Sun J, Zhang Y, Wang H, Wang Y, Yang Y, Kong Q, et al. : Clinical outcomes of primary and revision untethering surgery in patients with tethered cord syndrome and spinal bifida. World Neurosurg 116 : e66-e70, 2018   DOI
38 Al-Holou WN, Muraszko KM, Garton HJ, Buchman SR, Maher CO : The outcome of tethered cord release in secondary and multiple repeat tethered cord syndrome. J Neurosurg Pediatr 4 : 28-36, 2009   DOI
39 Alzahrani A, Alsowayan O, Farmer JP, Capolicchio JP, Jednak R, El-Sherbiny M : Comprehensive analysis of the clinical and urodynamic outcomes of secondary tethered spinal cord before and after spinal cord untethering. J Pediatr Urol 12 : 101.e1-e6, 2016   DOI
40 Blount JP, Tubbs RS, Okor M, Tyler-Kabara EC, Wellons JC 3rd, Grabb PA, et al. : Supraplacode spinal cord transection in paraplegic patients with myelodysplasia and repetitive symptomatic tethered spinal cord. J Neurosurg 103(1 Suppl) : 36-39, 2005
41 Bragg TM, Iskandar BJ : Lipomyelomeningocele in Winn HR (ed) : Youmans and Winn Neurological Surgery, ed 7. Philadelphia : Elsevier, 2017, Vol 2, pp1834-1841
42 Cochrane DD : Cord untethering for lipomyelomeningocele : expectation after surgery. Neurosurg Focus 23 : E9, 2007   DOI
43 Cohrs G, Drucks B, Surie JP, Vokuhl C, Synowitz M, Held-Feindt J, et al. : Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery. Childs Nerv Syst 35 : 315-328, 2019   DOI
44 Colak A, Pollack IF, Albright AL : Recurrent tethering: a common longterm problem after lipomyelomeningocele repair. Pediatr Neurosurg 29 : 184-190, 1998   DOI
45 Garces J, Mathkour M, Scullen T, Kahn L, Biro E, Pham A, et al. : First case of autonomic dysreflexia following elective lower thoracic spinal cord transection in a spina bifida adult. World Neurosurg 108 : 988. e1-988.e5, 2017   DOI
46 Cornips EM, Razenberg FG, van Rhijn LW, Soudant DL, van Raak EP, Weber JW, et al. : The lumbosacral angle does not reflect progressive tethered cord syndrome in children with spinal dysraphism. Childs Nerv Syst 26 : 1757-1764, 2010   DOI
47 Faggin R, Drigo P, Denaro L, Sartori S, d'Avella D : Hydromyelia associated with spinal lipoma of the conus: case report. Spine (Phila Pa 1976) 35 : E1069-E1071, 2010   DOI