Memantine Induces NMDAR1-Mediated Autophagic Cell Death in Malignant Glioma Cells |
Yoon, Wan-Soo
(Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea)
Yeom, Mi-Young (Clinical Research Laboratory, Incheon St. Mary's Hospital, The Catholic University of Korea) Kang, Eun-Sun (Clinical Research Laboratory, Incheon St. Mary's Hospital, The Catholic University of Korea) Chung, Yong-An (Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea) Chung, Dong-Sup (Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea) Jeun, Sin-Soo (Department of Neurosurgery, Seoul St. Mary's Hospital, The Catholic University of Korea) |
1 | Stepulak A, Sifringer M, Rzeski W, Endesfelder S, Gratopp A, Pohl EE, et al. : NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc Natl Acad Sci USA 102 : 15605-15610, 2005 DOI |
2 | Chen M, Lu TJ, Chen XJ, Zhou Y, Chen Q, Feng XY, et al. : Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke 39 : 3042-3048, 2008 DOI |
3 | de Groot J, Sontheimer H : Glutamate and the biology of gliomas. Glia 59 : 1181-1189, 2011 DOI |
4 | de Groot JF, Piao Y, Lu L, Fuller GN, Yung WK : Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation. J Neurooncol 88 : 121-133, 2008 DOI |
5 | Fan G, Sun B, Wu Z, Guo Q, Guo Y : In vivo single-voxel proton MR spectroscopy in the differentiation of high-grade gliomas and solitary metastases. Clin Radiol 59 : 77-85, 2004 DOI |
6 | Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, et al. : Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci 27 : 7987-8001, 2007 DOI |
7 | Johnson JW, Kotermanski SE : Mechanism of action of memantine. Curr Opin Pharmacol 6 : 61-67, 2006 DOI |
8 | Kihara K, Kabeya Y, Ohsumi Y, Yoshimori T : Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2 : 330-335, 2001 DOI |
9 | Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. : Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8 : 445-544, 2012 DOI |
10 | Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, et al. : NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27 : 2846-2857, 2007 DOI |
11 | McComb RD, Burger PC : Pathologic analysis of primary brain tumors. Neurol Clin 3 : 711-728, 1985 DOI |
12 | Abdul M, Hoosein N : N-methyl-D-aspartate receptor in human prostate cancer. J Membr Biol 205 : 125-128, 2005 DOI |
13 | Adamson C, Kanu OO, Mehta AI, Di C, Lin N, Mattox AK, et al. : Glioblastoma multiforme: a review of where we have been and where we are going. Expert Opin Investig Drugs 18 : 1061-1083, 2009 DOI |
14 | Behrens PF, Langemann H, Strohschein R, Draeger J, Hennig J : Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study. J Neurooncol 47 : 11-22, 2000 DOI |
15 | Besshoh S, Bawa D, Teves L, Wallace MC, Gurd JW : Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and postsynaptic densities following transient global ischemia in the rat brain. J Neurochem 93 : 186-194, 2005 DOI |
16 | Bigford GE, Alonso OF, Dietrich D, Keane RW : A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury. J Neurotrauma 26 : 703-720, 2009 DOI |
17 | Witt A, Macdonald N, Kirkpatrick P : Memantine hydrochloride. Nat Rev Drug Discov 3 : 109-110, 2004 DOI |
18 | Surawicz TS, Davis F, Freels S, Laws ER Jr, Menck HR : Brain tumor survival: results from the National Cancer Data Base. J Neurooncol 40 : 151-160, 1998 DOI |
19 | Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M : Glutamate release promotes growth of malignant gliomas. Nat Med 7 : 1010-1015, 2001 DOI |
20 | Watanabe K, Kanno T, Oshima T, Miwa H, Tashiro C, Nishizaki T : The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells. Biochem Biophys Res Commun 367 : 487-490, 2008 DOI |
21 | Ye ZC, Sontheimer H : Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 59 : 4383-4391, 1999 |
22 | Rijpkema M, Schuuring J, van der MY, van der GM, Bernsen H, Boerman R, et al. : Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging. NMR Biomed 16 : 12-18, 2003 DOI |
23 | Moots PL, Maciunas RJ, Eisert DR, Parker RA, Laporte K, Abou-Khalil B : The course of seizure disorders in patients with malignant gliomas. Arch Neurol 52 : 717-724, 1995 DOI |
24 | North WG, Gao G, Jensen A, Memoli VA, Du J : NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment. Clin Pharmacol 2 : 31-40, 2010 |
25 | Piao Y, Lu L, de Groot J : AMPA receptors promote perivascular glioma invasion via beta1 integrin dependent adhesion to the extracellular matrix. Neuro Oncol 11 : 260-273, 2009 DOI |
26 | Rothman SM, Olney JW : Excitotoxicity and the NMDA receptor-still lethal after eight years. Trends Neurosci 18 : 57-58, 1995 |
27 | Ruban A, Berkutzki T, Cooper I, Mohar B, Teichberg VI : Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas. Invest New Drugs 30 : 2226-2235, 2012 DOI |
28 | Rzeski W, Turski L, Ikonomidou C : Glutamate antagonists limit tumor growth. Proc Natl Acad Sci USA 98 : 6372-6377, 2001 DOI |
29 | Schunemann DP, Grivicich I, Regner A, Leal LF, de Araujo DR, Jotz GP, et al. : Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line. Pathol Oncol Res 16 : 285-293, 2010 DOI |
30 | Sontheimer H : A role for glutamate in growth and invasion of primary brain tumors. J Neurochem 105 : 287-295, 2008 DOI |
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